Výsledky vyhledávání - "Dragos Vizitiu"

Binding of Phosphates to Aminocyclodextrin Biomimetics

Autor: Gregory R. J. Thatcher, Dragos Vizitiu

Publikováno v: The Journal of Organic Chemistry. 64:6235-6238

Aminocyclodextrins (ACDs) in which the primary face is perfacially substituted with amino pendant groups provide three potential biomimetic binding domains: the hydrophobic cavity, the cationic annulus, and the corona formed by the pendant tendrils.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48fdf75f49a70433f06ce34dad6dca2f
https://doi.org/10.1021/jo9902392

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Synthesis of Monofacially Functionalized Cyclodextrins Bearing Amino Pendent Groups

Autor: Caroline S. Walkinshaw, Borio I. Gorin, Dragos Vizitiu, Gregory R. J. Thatcher

Publikováno v: The Journal of Organic Chemistry. 62:8760-8766

Derivatives of the cyclodextrins, αCD, βCD, and γCD, in which all primary hydroxyls are substituted by amine pendant groups, may be synthesized efficiently from the per-6-bromo-6-deoxy-CD derivatives by direct reaction with amines. These ACD deriv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9bc3bfe3701dc37bea5b6e958b163708
https://doi.org/10.1021/jo9711549

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Inhibition of phosphatidylinositol-specific phospholipase C: Studies on synthetic substrates, inhibitors and a synthetic enzyme

Autor: Angela G. Kriste, Dragos Vizitiu, Gregory R. J. Thatcher, A. Stewart Campbell

Publikováno v: Journal of Molecular Recognition. 9:197-209

Enzyme inhibition studies on phosphatidylinositol-specific phospholipase C (PI-PLC) from B. Cereus were performed in order to gain an understanding of the mechanism of the PI-PLC family of enzymes and to aid inhibitor design. Inhibition studies on tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f96179207275c06bcd57c69521c17bf
https://doi.org/10.1002/(sici)1099-1352(199603)9:2<197::aid-jmr263>3.0.co

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X-ray crystal structures of rabbit N-acetylglucosaminyltransferase I (GnT I) in complex with donor substrate analogues

Autor: Stephen G. Withers, Roni D. Gordon, Malathy Satkunarajah, Dengbo Ma, Prashanth Sivarajah, Dragos Vizitiu, James M. Rini, Chris A. Tarling

Publikováno v: Journal of molecular biology. 360(1)

The Golgi-resident glycosyltransferase, UDP-N-acetyl-d-glucosamine:alpha-3-d-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I), initiates the conversion of high-mannose oligosaccharides to complex and hybrid structures in the biosynthesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c986e1376fe4ee7382aad542d1072e30
https://pubmed.ncbi.nlm.nih.gov/16769084

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Amino-cyclodextrins as biomimetics: catalysis of the Kemp elimination

Autor: Paul G. McCracken, Yu Wang, Colin G. Ferguson, Caroline S. Walkinshaw, Gregory R. J. Thatcher, Dragos Vizitiu

Publikováno v: Journal of the Chemical Society, Perkin Transactions 2. :911-912

Synthetic amino-cyclodextrins (ACDs), perfunctionalized with pendant amines at the primary face, catalyse the Kemp elimination at physiological pH, in simile with proteins and synzymes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c186f570de9a76eb04ee8a34aead339
https://doi.org/10.1039/a901121h

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A metallomicelle enzyme model for phospholipase C catalysis and inhibition

Autor: Dragos Vizitiu, Gregory R. J. Thatcher, Angela G. Kriste

Publikováno v: Chemical Communications. :913

A CuII metallomicelle mimics phospholipase C enzymes in catalysis and inhibition of transesterification reactions of phosphate diesters.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93773197323fc04f06bd6315321f09f0
https://doi.org/10.1039/cc9960000913

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