Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Dragomir Milovanovic"'
Autor:
Joshua Jackson, Christian Hoffmann, Enzo Scifo, Han Wang, Lena Wischhof, Antonia Piazzesi, Mrityunjoy Mondal, Hanna Shields, Xuesi Zhou, Magali Mondin, Eanna B. Ryan, Hermann Döring, Jochen H. M. Prehn, Klemens Rottner, Gregory Giannone, Pierluigi Nicotera, Dan Ehninger, Dragomir Milovanovic, Daniele Bano
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-17 (2024)
Abstract Abnormal intraneuronal accumulation of soluble and insoluble α-synuclein (α-Syn) is one of the main pathological hallmarks of synucleinopathies, such as Parkinson’s disease (PD). It has been well documented that the reversible liquid-liq
Externí odkaz:
https://doaj.org/article/997bb81463e54820a4534745f1061001
Autor:
Christian Hoffmann, Jakob Rentsch, Taka A. Tsunoyama, Akshita Chhabra, Gerard Aguilar Perez, Rajdeep Chowdhury, Franziska Trnka, Aleksandr A. Korobeinikov, Ali H. Shaib, Marcelo Ganzella, Gregory Giannone, Silvio O. Rizzoli, Akihiro Kusumi, Helge Ewers, Dragomir Milovanovic
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Neuronal transmission relies on the regulated secretion of neurotransmitters, which are packed in synaptic vesicles (SVs). Hundreds of SVs accumulate at synaptic boutons. Despite being held together, SVs are highly mobile, so that they can b
Externí odkaz:
https://doaj.org/article/2a1d991d3f71465399ac99180aa4aa83
Autor:
Isabel Bünger, Ivan Talucci, Jakob Kreye, Markus Höltje, Konstantin L. Makridis, Helle Foverskov Rasmussen, Scott van Hoof, César Cordero-Gomez, Tim Ullrich, Eva Sedlin, Kai Oliver Kreissner, Christian Hoffmann, Dragomir Milovanovic, Paul Turko, Friedemann Paul, Jessica Meckies, Stefan Verlohren, Wolfgang Henrich, Rabih Chaoui, Hans Michael Maric, Angela M. Kaindl, Harald Prüss
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 33, Iss , Pp 100678- (2023)
Anti-neuronal autoantibodies can be transplacentally transferred during pregnancy and may cause detrimental effects on fetal development. It is unclear whether autoantibodies against synapsin-I, one of the most abundant synaptic proteins, are associa
Externí odkaz:
https://doaj.org/article/5cee482d828a46ee9bcb87e2a8908a06
Autor:
Kiara Freitag, Nele Sterczyk, Sarah Wendlinger, Benedikt Obermayer, Julia Schulz, Vadim Farztdinov, Michael Mülleder, Markus Ralser, Judith Houtman, Lara Fleck, Caroline Braeuning, Roberto Sansevrino, Christian Hoffmann, Dragomir Milovanovic, Stephan J. Sigrist, Thomas Conrad, Dieter Beule, Frank L. Heppner, Marina Jendrach
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Deposition of amyloid beta (Aβ) and hyperphosphorylated tau along with glial cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer’s disease (AD). In recent years, impairment of autophagy has been iden
Externí odkaz:
https://doaj.org/article/6ec625ec673842d59b1af73f89fb8e97
Autor:
Isabel Bünger, Konstantin L. Makridis, Jakob Kreye, Marc Nikolaus, Eva Sedlin, Tim Ullrich, Christian Hoffmann, Johannes Vincent Tromm, Helle Foverskov Rasmussen, Dragomir Milovanovic, Markus Höltje, Harald Prüss, Angela M. Kaindl
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Maternal autoantibodies can be transmitted diaplacentally, with potentially deleterious effects on neurodevelopment. Synapsin 1 (SYN1) is a neuronal protein that is important for synaptic communication and neuronal plasticity. While monoallelic loss
Externí odkaz:
https://doaj.org/article/60487b530ac44f82ab095eaf3600566c
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/8d3d00ac5f944df291b7a2329ca2b2c8
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The protein α-synuclein, which is well-known for its links to Parkinson’s Disease, is associated with synaptic vesicles (SVs) in nerve terminals. Despite intensive studies, its precise physiological function remains elusive. Accumulating evidence
Externí odkaz:
https://doaj.org/article/033c546321004a0d837e1a780e07b9d3
Autor:
Katarina Milicevic, Branislava Rankovic, Pavle R. Andjus, Danijela Bataveljic, Dragomir Milovanovic
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Liquid-liquid phase separation (LLPS) is emerging as a major principle for the mesoscale organization of proteins, RNAs, and membrane-bound organelles into biomolecular condensates. These condensates allow for rapid cellular responses to changes in m
Externí odkaz:
https://doaj.org/article/7c597cd0e34f40649f9f087dfceb46bd
Autor:
Daehun Park, Yumei Wu, Sang-Eun Lee, Goeun Kim, Seonyoung Jeong, Dragomir Milovanovic, Pietro De Camilli, Sunghoe Chang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Synaptic vesicle clusters were proposed to represent phase separated condensates. Here, the authors show that only two proteins, synapsin and synaptophysin, are sufficient to make vesicle clusters in fibroblasts which are similar to those found at sy
Externí odkaz:
https://doaj.org/article/6aa311dacba44c169f50903eb2d79e75
Autor:
Franziska Trnka, Christian Hoffmann, Han Wang, Roberto Sansevrino, Branislava Rankovic, Benjamin R. Rost, Dietmar Schmitz, H. Broder Schmidt, Dragomir Milovanovic
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that leads to the death of upper and lower motor neurons. While most cases of ALS are sporadic, some of the familial forms of the disease are caused by mutations in the ge
Externí odkaz:
https://doaj.org/article/cb81296dec8f42cabb270272b88aecfb