Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Drago Robert Sliskovic"'
Publikováno v:
Biological Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3c2684b8df991e0ee5004cc886ee0d1
https://doi.org/10.1201/9781003077336-3
https://doi.org/10.1201/9781003077336-3
Autor:
Takuma Etoh, Drago Robert Sliskovic, Hua Li, J. Thomas Peterson, Francis G. Spinale, Thomas M.A. Bocan, Patrick Michael O'brien, Hussein Hallak, Linda S B Johnson, Mytsi L. Coker
Publikováno v:
Circulation. 103:2303-2309
Background —Matrix metalloproteinase (MMP) activation contributes to tissue remodeling in several disease states, and increased MMP activity has been observed in left ventricular (LV) failure. The present study tested the hypothesis that MMP inhibi
Publikováno v:
Lipids. 33:489-498
WAY-121,898 is an inhibitor of pancreatic cholesteryl ester hydrolase (pCEH). After confirming its in vitro potency and relative lack of a major effect on acyl-CoA:cholesterol acyltransferase (ACAT), it was found that this compound lowers plasma chol
Autor:
Helen T. Lee, Brian R. Krause, Bruce D. Roth, R. L. Stanfield, W. H. Roark, Joseph Armand Picard, Drago Robert Sliskovic, R. F. Bousley, K. L. Hamelehle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:289-294
Sulfoacetic acid, phosphoramidate, and phosphoramide analogs of the ACAT inhibitors, CI-999 and CI-1011 were synthesized. The structure-activity relationships of these compounds as ACAT inhibitors are described.
Publikováno v:
Expert Opinion on Investigational Drugs. 4:353-387
Elevated blood cholesterol is an established risk factor for coronary heart disease (CHD), and the basis for treatment is normalisation of LDL-cholesterol (LDL-C). If dietary measures fail, inhibitors of HMG-CoA reductase (HMGR) potently lower LDL-C,
Autor:
Timothy R. Hurley, R. L. Stanfield, Maureen K. Anderson, Brian R. Krause, Drago Robert Sliskovic, Adele Bernabei, Patrick Michael O'brien, R. F. Bousley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:295-300
The syntheses and biological activities for anilides derived from 2-phenyl-2-(dodecyl-2H-tetrazol-5-yl)acetic acid are described. Evidence is provided that one of these compounds, (+)- 8b , stereoselectively inhibits ACAT in vitro and possesses super
Autor:
R. F. Bousley, Brian R. Krause, Helen T. Lee, K. L. Hamelehle, Drago Robert Sliskovic, R. L. Stanfield
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:301-306
The syntheses and biological activities of a series of novel sulfonamide tetrazole derivatives are reported. The ability of these compounds to inhibit ACAT is described. Such agents may decrease the absorption of dietary cholesterol in the intestine
Autor:
Brian R. Krause, Maureen K. Anderson, R. L. Stanfield, R. F. Bousley, Drago Robert Sliskovic, Patrick Michael O'brien
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:289-294
The identification of tetrazole benzamide and nicotinamide derivatives as new structural classes of potent ACAT inhibitors is described. The ensuing structure-activity relationship (SAR) studies revealed that retroamide 8c and 7q possesses comparable
Autor:
Bruce D. Roth, Milton L. Hoefle, A. W. Chucholowski, Roger S. Newton, C. D. Stratton, C. J. Blankley, Daniel F. Ortwine, Michael W. Wilson, C. S. Sekerke, E. Ferguson, Drago Robert Sliskovic
Publikováno v:
ChemInform. 22
Autor:
K. L. Hamelehle, C. J. Blankley, Drago Robert Sliskovic, R. L. Stanfield, Bruce D. Roth, Patrick Michael O'brien, Michael W. Wilson, Brian R. Krause
Publikováno v:
ChemInform. 25