Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Dragica Blazevic"'
Autor:
Matthias Düchs, Dragica Blazevic, Philipp Rechtsteiner, Cynthia Kenny, Thorsten Lamla, Sarah Low, Jimmy Savistchenko, Manuela Neumann, Ronald Melki, Tanja Schönberger, Birgit Stierstorfer, David Wyatt, Frederik Igney, Thomas Ciossek
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Prion-like transmission of pathology in α-synucleinopathies like Parkinson’s disease or multiple system atrophy is increasingly recognized as one potential mechanism to address disease progression. Active and passive immunotherapies targe
Externí odkaz:
https://doaj.org/article/bfa18d4f4cb54bf398d1a6ddf489f5be
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 360-369 (2022)
Adeno-associated virus (AAV) vector applications are often limited by capsid-directed humoral immune responses, mainly through neutralizing antibodies (NAbs), which are present throughout the human population due to natural AAV infections. Currently,
Externí odkaz:
https://doaj.org/article/80c63c35850c401f9f6c93aa55504ed4
Autor:
Benjamin Strobel, Maike Spöring, Holger Klein, Dragica Blazevic, Werner Rust, Sergi Sayols, Jörg S. Hartig, Sebastian Kreuz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Riboswitches can mediate ligand-dependent RNA cleavage and splicing to control gene expression. Here the authors present a method to functionally screen large libraries and identify functional variants.
Externí odkaz:
https://doaj.org/article/490841ff4d214574955fa93d388d9d36
Autor:
Matthias Düchs, Dragica Blazevic, Philipp Rechtsteiner, Cynthia Kenny, Thorsten Lamla, Sarah Low, Jimmy Savistchenko, Manuela Neumann, Ronald Melki, Tanja Schönberger, Birgit Stierstorfer, David Wyatt, Frederik Igney, Thomas Ciossek
Prion-like transmission of pathology in α-synucleinopathies like Parkinson’s disease or multiple system atrophy is increasingly recognized as one potential mechanism to address disease progression. Active and passive immunotherapies targeting inso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8926442dadbf8f2667aede74b3b6140c
https://doi.org/10.1101/2022.11.30.518485
https://doi.org/10.1101/2022.11.30.518485
Publikováno v:
Molecular therapy. Methodsclinical development. 25
Adeno-associated virus (AAV) vector applications are often limited by capsid-directed humoral immune responses, mainly through neutralizing antibodies (NAbs), which are present throughout the human population due to natural AAV infections. Currently,
Autor:
Matthias J. Düchs, Katja S. Baum-Kroker, Sebastian Kreuz, Dirk Gottschling, Clemens Braun, Bernhard Schmid, Philipp Rechtsteiner, Benjamin Strobel, Dragica Blazevic, Thomas Ciossek, Jörg S. Hartig
Publikováno v:
ACS synthetic biology. 9(6)
Adeno-associated viral (AAV) vector-mediated gene therapy holds great potential for future medical applications. However, to facilitate safer and broader applicability and to enable patient-centric care, therapeutic protein expression should be contr
Autor:
Maike Spöring, Sebastian Kreuz, Jörg S. Hartig, Holger Klein, Dragica Blazevic, Sergi Sayols, Benjamin Strobel, Werner Rust
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Synthetic riboswitches mediating ligand-dependent RNA cleavage or splicing-modulation represent elegant tools to control gene expression in various applications, including next-generation gene therapy. However, due to the limited understanding of con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4695785dea9690d6bd1fb694f714978e
Autor:
Dragica Blazevic, Snezana Maljevic, Ozlem Yalcin, Heidi Loeffler, Holger Lerche, Georgios Naros, Ortrud K. Steinlein, Hande Caglayan
Publikováno v:
Human Mutation. 32:E2283-E2293
Benign familial neonatal seizures (BFNS) are a dominant epilepsy syndrome caused by mutations in the voltage-gated potassium channels K(V) 7.2 and K(V) 7.3. We examined the molecular pathomechanism of a BFNS-causing mutation (p.N258S) in the extracel
Autor:
Kailash P. Bhatia, Knut Brockmann, Francesco Margari, Saisudha Koka, Alberto Salvo-Vargas, Felix M. Mottaghy, Christoph Kamm, Mark J. Edwards, Alexander Storch, Eduard Kraft, Snezana Maljevic, Michael Fauler, Guiscard Seebohm, Thomas Gasser, Holger Lerche, Thomas V. Wuttke, Stephan M. Huber, Arnulf Pekrun, Camelia Lang, Anna Presicci, Susanne A. Schneider, Lucia Margari, Judith S. Kempfle, Robert Roebling, Dragica Blazevic, Alexander Münchau, Frank Lehmann-Horn, Yvonne G. Weber, Florian Lang
Publikováno v:
Journal of Clinical Investigation. 118:2157-2168
Paroxysmal dyskinesias are episodic movement disorders that can be inherited or are sporadic in nature. The pathophysiology underlying these disorders remains largely unknown but may involve disrupted ion homeostasis due to defects in cell-surface ch
Autor:
Michael Walter, Claudia Oecking, Oliver Batistič, Katrin Weckermann, Christian Näke, Katia Schütze, Karin Schumacher, Jörg Kudla, Christopher Grefen, Christina Chaban, Klaus Harter, Dragica Blazevic
Publikováno v:
The Plant Journal. 40:428-438
Dynamic networks of protein-protein interactions regulate numerous cellular processes and determine the ability to respond appropriately to environmental stimuli. However, the investigation of protein complex formation in living plant cells by method