Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Dragana Despotovic"'
Autor:
Liam M. Longo, Dragana Despotovic, Dan S. Tawfik, Tali Scherf, Einav Aharon, Ita Gruić-Sovulj, Amit Kahana
Publikováno v:
Biochemistry
Polyamines are known to mediate diverse biological processes, and specifically to bind and stabilize compact conformations of nucleic acids, acting as chemical chaperones that promote folding by offsetting the repulsive negative charges of the phosph
Autor:
Alon Savidor, Olena Trofimyuk, Andrea Castelli, Dan S. Tawfik, Yishai Levin, Artem Dubovetskyi, Liam M. Longo, Yacov Ashani, Dragana Despotovic, Einat Segev, Einav Aharon, Laura Fumagalli, Haim Leader, Kesava Phaneendra Cherukuri
Anthropogenic organophosphates (AOPs), such as phosphotriesters, are used extensively as plasticizers, flame retardants, nerve agents and pesticides. Soil bacteria bearing a phosphotriesterase (PTE) can degrade AOPs, but whether bacteria are capable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34856e5058887262ab012f3b884e6608
https://doi.org/10.1101/2021.10.18.464763
https://doi.org/10.1101/2021.10.18.464763
Publikováno v:
Nature ecologyevolution. 5(10)
Autor:
Dragana Despotovic, Dan S. Tawfik
Publikováno v:
ChemSystemsChem. 3
Autor:
Dragana Despotovic, Einav Aharon, Ita Gruić-Sovulj, Liam M. Longo, Tali Scherf, Amit Kahana, Dan S. Tawfik
Polyamines are known to mediate diverse biological processes, and specifically to bind and stabilize compact conformations of nucleic acids, acting as chemical chaperones that promote folding by offsetting the repulsive negative charges of the phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d79738128d795c1681893527e023edd4
https://doi.org/10.1101/2020.10.01.321877
https://doi.org/10.1101/2020.10.01.321877
Autor:
Jagoda Jabłońska, Liam M. Longo, Matthew J. Walker, Orit Weil‐Ktorza, Yael Fridmann-Sirkis, Gabriele Varani, Norman Metanis, Dragana Despotovic, Dan S. Tawfik
Publikováno v:
Proc Natl Acad Sci U S A
De novo emergence demands a transition from disordered polypeptides into structured proteins with well-defined functions. However, can polypeptides confer functions of evolutionary relevance, and how might such polypeptides evolve into modern protein
Autor:
Dragana Despotovic, Jagoda Jabłońska, Matthew J. Walker, Gabriele Varani, Yael Fridmann-Sirkis, Liam M. Longo, Dan S. Tawfik, Norman Metanis, Orit Weil‐Ktorza
De novo emergence, and emergence of the earliest proteins specifically, demands a transition from disordered polypeptides into structured proteins with well-defined functions. However, can peptides confer evolutionary relevant functions, let alone wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bf5285b00049a08e8a691f7371d539
Autor:
Alon Savidor, Dan S. Tawfik, Laura Fumagalli, Alexander Brandis, Yishai Levin, Dragana Despotovic
Publikováno v:
The FEBS Journal. 284:2194-2215
Under stress, metabolism is changing: specific up- or down-regulation of proteins and metabolites occurs as well as side effects. Distinguishing specific stress-signaling metabolites (alarmones) from side products (damage metabolites) is not trivial.
Autor:
Dragana Despotovic, Artem Dubovetskyi, Yacov Ashani, Dan S. Tawfik, Einav Aharon, Haim Leader
Publikováno v:
Protein engineering, designselection : PEDS. 32(4)
Nerve agents are organophosphates that potently inhibit acetylcholinesterase and their enzymatic detoxification has been a long-standing goal. Nerve agents vary widely in size, charge, hydrophobicity, and the cleavable ester bond. A single enzyme is
Autor:
Ljubica Vojcic, Marco Bocola, Karl-Heinz Maurer, Ulrich Schwaneberg, Milan Blanusa, Martin Zacharias, Ronny Martinez, Dragana Despotovic
Publikováno v:
Journal of biotechnology. 167(3)
Enzyme promiscuity describes the ability of biocatalysts to catalyze conversions beyond their natural reactions. Enzyme engineering to promote side reactions is attractive for synthetic and industrial applications. For instance, a subtilisin Carlsber