Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Dragana Despotovic"'
Autor:
Liam M. Longo, Dragana Despotovic, Dan S. Tawfik, Tali Scherf, Einav Aharon, Ita Gruić-Sovulj, Amit Kahana
Publikováno v:
Biochemistry
Polyamines are known to mediate diverse biological processes, and specifically to bind and stabilize compact conformations of nucleic acids, acting as chemical chaperones that promote folding by offsetting the repulsive negative charges of the phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b4a3b366ecb3619ed0c2c393f05d02
https://doi.org/10.1021/acs.biochem.0c00800
https://doi.org/10.1021/acs.biochem.0c00800
Autor:
Alon Savidor, Olena Trofimyuk, Andrea Castelli, Dan S. Tawfik, Yishai Levin, Artem Dubovetskyi, Liam M. Longo, Yacov Ashani, Dragana Despotovic, Einat Segev, Einav Aharon, Laura Fumagalli, Haim Leader, Kesava Phaneendra Cherukuri
Anthropogenic organophosphates (AOPs), such as phosphotriesters, are used extensively as plasticizers, flame retardants, nerve agents and pesticides. Soil bacteria bearing a phosphotriesterase (PTE) can degrade AOPs, but whether bacteria are capable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34856e5058887262ab012f3b884e6608
https://doi.org/10.1101/2021.10.18.464763
https://doi.org/10.1101/2021.10.18.464763
Publikováno v:
Nature ecologyevolution. 5(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6734dcb54298b82a949c3eb111c4c3
https://pubmed.ncbi.nlm.nih.gov/34400827
https://pubmed.ncbi.nlm.nih.gov/34400827
Autor:
Dragana Despotovic, Dan S. Tawfik
Publikováno v:
ChemSystemsChem. 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27c9afe3f2fc7cf2911315066b158a7a
https://doi.org/10.1002/syst.202100002
https://doi.org/10.1002/syst.202100002
Autor:
Dragana Despotovic, Einav Aharon, Ita Gruić-Sovulj, Liam M. Longo, Tali Scherf, Amit Kahana, Dan S. Tawfik
Polyamines are known to mediate diverse biological processes, and specifically to bind and stabilize compact conformations of nucleic acids, acting as chemical chaperones that promote folding by offsetting the repulsive negative charges of the phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d79738128d795c1681893527e023edd4
https://doi.org/10.1101/2020.10.01.321877
https://doi.org/10.1101/2020.10.01.321877
Autor:
Jagoda Jabłońska, Liam M. Longo, Matthew J. Walker, Orit Weil‐Ktorza, Yael Fridmann-Sirkis, Gabriele Varani, Norman Metanis, Dragana Despotovic, Dan S. Tawfik
Publikováno v:
Proc Natl Acad Sci U S A
De novo emergence demands a transition from disordered polypeptides into structured proteins with well-defined functions. However, can polypeptides confer functions of evolutionary relevance, and how might such polypeptides evolve into modern protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf82580442cb3960212688085b19483
https://pubmed.ncbi.nlm.nih.gov/32561643
https://pubmed.ncbi.nlm.nih.gov/32561643
Autor:
Dragana Despotovic, Jagoda Jabłońska, Matthew J. Walker, Gabriele Varani, Yael Fridmann-Sirkis, Liam M. Longo, Dan S. Tawfik, Norman Metanis, Orit Weil‐Ktorza
De novo emergence, and emergence of the earliest proteins specifically, demands a transition from disordered polypeptides into structured proteins with well-defined functions. However, can peptides confer evolutionary relevant functions, let alone wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bf5285b00049a08e8a691f7371d539
Autor:
Alon Savidor, Dan S. Tawfik, Laura Fumagalli, Alexander Brandis, Yishai Levin, Dragana Despotovic
Publikováno v:
The FEBS Journal. 284:2194-2215
Under stress, metabolism is changing: specific up- or down-regulation of proteins and metabolites occurs as well as side effects. Distinguishing specific stress-signaling metabolites (alarmones) from side products (damage metabolites) is not trivial.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc75cedbdedead8f8090bb8af91dc47
https://doi.org/10.1111/febs.14113
https://doi.org/10.1111/febs.14113
Autor:
Dragana Despotovic, Artem Dubovetskyi, Yacov Ashani, Dan S. Tawfik, Einav Aharon, Haim Leader
Publikováno v:
Protein engineering, designselection : PEDS. 32(4)
Nerve agents are organophosphates that potently inhibit acetylcholinesterase and their enzymatic detoxification has been a long-standing goal. Nerve agents vary widely in size, charge, hydrophobicity, and the cleavable ester bond. A single enzyme is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe583013d9b5affdf69e3ac9d7d10cb
https://pubmed.ncbi.nlm.nih.gov/31612205
https://pubmed.ncbi.nlm.nih.gov/31612205
Autor:
Ljubica Vojcic, Marco Bocola, Karl-Heinz Maurer, Ulrich Schwaneberg, Milan Blanusa, Martin Zacharias, Ronny Martinez, Dragana Despotovic
Publikováno v:
Journal of biotechnology. 167(3)
Enzyme promiscuity describes the ability of biocatalysts to catalyze conversions beyond their natural reactions. Enzyme engineering to promote side reactions is attractive for synthetic and industrial applications. For instance, a subtilisin Carlsber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810caad7810070e2715c0bba835e0c6b
https://pubmed.ncbi.nlm.nih.gov/23835157
https://pubmed.ncbi.nlm.nih.gov/23835157