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Autor:
Sergey Dzekhtser, Michael Krohn, Isaac Kennedy, Changren Yan, David E. Zembower, Glenn L. Stahl, Chen Wei, Robert A. Erickson, Livia A. Enache, Dragan Ristic, Alex S. Kiselyov, Frank W. Muellner, Vincent Sandanayaka, Jennifer Winger, David Sullins, Jasbir Singh
Publikováno v:
Organic Process Research & Development. 13:1177-1184
DG-051B is a first-in-class small molecule inhibitor of leukotriene A4 hydrolase (LTA4H), currently in Phase II clinical development for the prevention of heart attack. Process optimization led from a linear seven-step synthetic procedure to a conver