Automated preclinical detection of mechanical pain hypersensitivity and analgesia.

Autor: Zhang Z; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, United States. D.P. Roberson is now with Blackbox Bio, LLC, Dallas, TX, United States. R. González-Cano is now with the Department of Pharmacology, University of Granada, Granada, Spain . N.K. Wimalasena is now with Decibel Therapeutics, Boston, MA, United States. N.L.M. Quintão is now with the Postgraduate Programe in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil . V. Fattori is now with the Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil . A.B. Wiltschko is now with the Google Research, Brain Team, Cambridge, MA, United States. N.A. Andrews is now with the Salk Institute for Biological Studies, La Jolla, CA, United States.; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., Roberson DP; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, United States. D.P. Roberson is now with Blackbox Bio, LLC, Dallas, TX, United States. R. González-Cano is now with the Department of Pharmacology, University of Granada, Granada, Spain . N.K. Wimalasena is now with Decibel Therapeutics, Boston, MA, United States. N.L.M. Quintão is now with the Postgraduate Programe in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil . V. Fattori is now with the Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil . A.B. Wiltschko is now with the Google Research, Brain Team, Cambridge, MA, United States. N.A. Andrews is now with the Salk Institute for Biological Studies, La Jolla, CA, United States.; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., Kotoda M; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, United States. D.P. Roberson is now with Blackbox Bio, LLC, Dallas, TX, United States. R. González-Cano is now with the Department of Pharmacology, University of Granada, Granada, Spain . N.K. Wimalasena is now with Decibel Therapeutics, Boston, MA, United States. N.L.M. Quintão is now with the Postgraduate Programe in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil . V. Fattori is now with the Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil . A.B. Wiltschko is now with the Google Research, Brain Team, Cambridge, MA, United States. N.A. Andrews is now with the Salk Institute for Biological Studies, La Jolla, CA, United States.; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., Boivin B; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, United States. D.P. Roberson is now with Blackbox Bio, LLC, Dallas, TX, United States. R. González-Cano is now with the Department of Pharmacology, University of Granada, Granada, Spain . N.K. Wimalasena is now with Decibel Therapeutics, Boston, MA, United States. N.L.M. Quintão is now with the Postgraduate Programe in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil . V. Fattori is now with the Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil . A.B. Wiltschko is now with the Google Research, Brain Team, Cambridge, MA, United States. N.A. Andrews is now with the Salk Institute for Biological Studies, La Jolla, CA, United States.; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., Bohnslav JP; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., González-Cano R; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, United States. D.P. Roberson is now with Blackbox Bio, LLC, Dallas, TX, United States. R. González-Cano is now with the Department of Pharmacology, University of Granada, Granada, Spain . N.K. Wimalasena is now with Decibel Therapeutics, Boston, MA, United States. N.L.M. Quintão is now with the Postgraduate Programe in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil . V. Fattori is now with the Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil . A.B. Wiltschko is now with the Google Research, Brain Team, Cambridge, MA, United States. N.A. Andrews is now with the Salk Institute for Biological Studies, La Jolla, CA, United States.; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., Yarmolinsky DA; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, United States. D.P. Roberson is now with Blackbox Bio, LLC, Dallas, TX, United States. R. González-Cano is now with the Department of Pharmacology, University of Granada, Granada, Spain . N.K. Wimalasena is now with Decibel Therapeutics, Boston, MA, United States. N.L.M. Quintão is now with the Postgraduate Programe in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil . V. Fattori is now with the Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil . A.B. Wiltschko is now with the Google Research, Brain Team, Cambridge, MA, United States. N.A. Andrews is now with the Salk Institute for Biological Studies, La Jolla, CA, United States.; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., Turnes BL; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, United States. D.P. Roberson is now with Blackbox Bio, LLC, Dallas, TX, United States. R. González-Cano is now with the Department of Pharmacology, University of Granada, Granada, Spain . N.K. Wimalasena is now with Decibel Therapeutics, Boston, MA, United States. N.L.M. Quintão is now with the Postgraduate Programe in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil . V. Fattori is now with the Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil . A.B. Wiltschko is now with the Google Research, Brain Team, Cambridge, MA, United States. N.A. Andrews is now with the Salk Institute for Biological Studies, La Jolla, CA, United States.; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., Wimalasena NK; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, United States. D.P. Roberson is now with Blackbox Bio, LLC, Dallas, TX, United States. R. González-Cano is now with the Department of Pharmacology, University of Granada, Granada, Spain . N.K. Wimalasena is now with Decibel Therapeutics, Boston, MA, United States. N.L.M. Quintão is now with the Postgraduate Programe in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil . V. Fattori is now with the Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil . A.B. Wiltschko is now with the Google Research, Brain Team, Cambridge, MA, United States. N.A. Andrews is now with the Salk Institute for Biological Studies, La Jolla, CA, United States.; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., Neufeld SQ; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., Barrett LB; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, United States. D.P. Roberson is now with Blackbox Bio, LLC, Dallas, TX, United States. R. González-Cano is now with the Department of Pharmacology, University of Granada, Granada, Spain . N.K. Wimalasena is now with Decibel Therapeutics, Boston, MA, United States. N.L.M. Quintão is now with the Postgraduate Programe in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil . V. Fattori is now with the Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil . A.B. Wiltschko is now with the Google Research, Brain Team, Cambridge, MA, United States. N.A. Andrews is now with the Salk Institute for Biological Studies, La Jolla, CA, United States.; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., Quintão NLM; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, United States. D.P. Roberson is now with Blackbox Bio, LLC, Dallas, TX, United States. R. González-Cano is now with the Department of Pharmacology, University of Granada, Granada, Spain . N.K. Wimalasena is now with Decibel Therapeutics, Boston, MA, United States. N.L.M. Quintão is now with the Postgraduate Programe in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil . V. Fattori is now with the Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil . A.B. Wiltschko is now with the Google Research, Brain Team, Cambridge, MA, United States. N.A. Andrews is now with the Salk Institute for Biological Studies, La Jolla, CA, United States.; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., Fattori V; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, United States. D.P. Roberson is now with Blackbox Bio, LLC, Dallas, TX, United States. R. González-Cano is now with the Department of Pharmacology, University of Granada, Granada, Spain . N.K. Wimalasena is now with Decibel Therapeutics, Boston, MA, United States. N.L.M. Quintão is now with the Postgraduate Programe in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil . V. Fattori is now with the Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil . A.B. Wiltschko is now with the Google Research, Brain Team, Cambridge, MA, United States. N.A. Andrews is now with the Salk Institute for Biological Studies, La Jolla, CA, United States.; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., Taub DG; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, United States. D.P. Roberson is now with Blackbox Bio, LLC, Dallas, TX, United States. R. González-Cano is now with the Department of Pharmacology, University of Granada, Granada, Spain . N.K. Wimalasena is now with Decibel Therapeutics, Boston, MA, United States. N.L.M. Quintão is now with the Postgraduate Programe in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil . V. Fattori is now with the Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil . A.B. Wiltschko is now with the Google Research, Brain Team, Cambridge, MA, United States. N.A. Andrews is now with the Salk Institute for Biological Studies, La Jolla, CA, United States.; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., Wiltschko AB; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., Andrews NA; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, United States. D.P. Roberson is now with Blackbox Bio, LLC, Dallas, TX, United States. R. González-Cano is now with the Department of Pharmacology, University of Granada, Granada, Spain . N.K. Wimalasena is now with Decibel Therapeutics, Boston, MA, United States. N.L.M. Quintão is now with the Postgraduate Programe in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil . V. Fattori is now with the Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil . A.B. Wiltschko is now with the Google Research, Brain Team, Cambridge, MA, United States. N.A. Andrews is now with the Salk Institute for Biological Studies, La Jolla, CA, United States.; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., Harvey CD; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., Datta SR; Department of Neurobiology, Harvard Medical School, Boston, MA, United States., Woolf CJ; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, United States. D.P. Roberson is now with Blackbox Bio, LLC, Dallas, TX, United States. R. González-Cano is now with the Department of Pharmacology, University of Granada, Granada, Spain . N.K. Wimalasena is now with Decibel Therapeutics, Boston, MA, United States. N.L.M. Quintão is now with the Postgraduate Programe in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil . V. Fattori is now with the Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Londrina State University, Londrina, Paraná, Brazil . A.B. Wiltschko is now with the Google Research, Brain Team, Cambridge, MA, United States. N.A. Andrews is now with the Salk Institute for Biological Studies, La Jolla, CA, United States.; Department of Neurobiology, Harvard Medical School, Boston, MA, United States.

Publikováno v: Pain [Pain] 2022 Dec 01; Vol. 163 (12), pp. 2326-2336. Date of Electronic Publication: 2022 May 11.

Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314.

Autor: Blake KJ; Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, MA, 02115, USA., Baral P; Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, MA, 02115, USA., Voisin T; Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, MA, 02115, USA., Lubkin A; Department of Microbiology, New York University School of Medicine, New York, NY, 10016, USA., Pinho-Ribeiro FA; Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, MA, 02115, USA., Adams KL; Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, MA, 02115, USA., Roberson DP; Department of Neurobiology, Harvard Medical School, Boston, MA, 02115, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, 02155, USA., Ma YC; Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, MA, 02115, USA., Otto M; Pathogen Molecular Genetics Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, 20814, USA., Woolf CJ; Department of Neurobiology, Harvard Medical School, Boston, MA, 02115, USA.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, 02155, USA., Torres VJ; Department of Microbiology, New York University School of Medicine, New York, NY, 10016, USA., Chiu IM; Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, MA, 02115, USA. isaac_chiu@hms.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2018 Jan 02; Vol. 9 (1), pp. 37. Date of Electronic Publication: 2018 Jan 02.

Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses.

Autor: Browne LE; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA; Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK. Electronic address: liam.browne@ucl.ac.uk., Latremoliere A; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA., Lehnert BP; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA., Grantham A; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA., Ward C; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA., Alexandre C; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA., Costigan M; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA; Department of Anesthesia, Boston Children's Hospital, Boston, MA 02115, USA., Michoud F; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA., Roberson DP; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA., Ginty DD; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA., Woolf CJ; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: clifford.woolf@childrens.harvard.edu.

Publikováno v: Cell reports [Cell Rep] 2017 Jul 05; Vol. 20 (1), pp. 89-98.

Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity.

Autor: Chiu IM; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, United States., Barrett LB; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, United States., Williams EK; Department of Cell Biology, Harvard Medical School, Boston, United States., Strochlic DE; Department of Cell Biology, Harvard Medical School, Boston, United States., Lee S; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, United States., Weyer AD; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, United States., Lou S; Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States., Bryman GS; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, United States., Roberson DP; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, United States., Ghasemlou N; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, United States., Piccoli C; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, United States., Ahat E; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, United States., Wang V; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, United States., Cobos EJ; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, United States., Stucky CL; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, United States., Ma Q; Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States., Liberles SD; Department of Cell Biology, Harvard Medical School, Boston, United States., Woolf CJ; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, United States.

Publikováno v: ELife [Elife] 2014 Dec 19; Vol. 3. Date of Electronic Publication: 2014 Dec 19.

Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review.

Autor: Roberson DP; FM Kirby Neurobiology Center and Department of Neurology, Children's Hospital, Boston, MA 02115, USA., Binshtok AM, Blasl F, Bean BP, Woolf CJ

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2011 Sep; Vol. 164 (1), pp. 48-58.