Both DNA binding domains of p53 are required for its ultra-rapid recruitment to sites of UV damage

Autor: Hc. Goh, Dp. Lane, Mp. Sheetz, Anushya Hariharan, Yh. Wang, T. Ho

p53 concentrates at DNA damage sites within two seconds upon UV laser micro-irradiation. Structural analysis shows that this very rapid response requires both the DNA binding and C-terminal domains of p53. This early recruitment response is also PARP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ca3f922bcd2381ad8bf254d1430f39

Monoclonal antibodies to a proenkephalin A fusion peptide synthesized in Escherichia coli recognize novel proenkephalin A precursor forms

Autor: Ba, Spruce, Jackson S, Pj, Lowry, Dp, Lane, David Glover

Publikováno v: Europe PubMed Central

Monoclonal antibodies have been generated to a chimeric peptide comprised of Escherichia coli beta-galactosidase fused to the amino acid sequence 69-207 of human preproenkephalin A. Two monoclonal antibodies, PE-1 and PE-2, were identified by their a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ce7d2e3907b46cc409cdce4f961a35d1
https://pubmed.ncbi.nlm.nih.gov/2461943

Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice

Autor: Pa, Burns, Cj, Kemp, Jv, Gannon, Dp, Lane, Rod Bremner, Balmain A

Publikováno v: Europe PubMed Central

Functional alterations or loss of tumor-suppressor genes are an important feature of neoplastic progression in humans. The employment of suitable animal model systems would greatly facilitate the detection and manipulation of such genes. We describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7863b4f9ae1cc55dd31ac9dfea287444
http://europepmc.org/abstract/med/1766680

Host proteins that bind to or mimic SV40 large T antigen: using antibodies to look at protein interactions and their significance

Autor: Sara Mole, Jv, Gannon, Ia, Anton, Mj, Ford, Dp, Lane

Publikováno v: Europe PubMed Central

The papovavirus SV40 is able to induce tumours in susceptible hosts and will transform cells in vitro. Its major early protein, large T antigen, is required for viral DNA synthesis, both in vivo and in vitro, and is also responsible for the oncogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::59ed0ef369376337b67ed16b763e27fb
http://europepmc.org/abstract/med/2478459

Controlling Drug Partitioning in Individual Protein Condensates through Laser-Induced Microscale Phase Transitions.

Autor: Leppert A; Department of Cell and Molecular Biology, Uppsala University, S-75124 Uppsala, Sweden.; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, S-17165 Solna, Sweden., Feng J; Bioproducts and Biosystems, Aalto University, Fi-00076 Aalto, Espoo, Finland., Railaite V; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, S-17165 Solna, Sweden., Bohn Pessatti T; Department of Anatomy Physiology and Biochemistry, Swedish University of Agricultural Sciences, S-75007 Uppsala, Sweden., Cerrato CP; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, S-17165 Solna, Sweden., Mörman C; Department of Biosciences and Nutrition, Karolinska Institutet, S-14157 Huddinge, Sweden.; Department of Biology and Chemistry, Paul Scherrer Institute, 5232 Villingen, Switzerland., Osterholz H; Department of Cell and Molecular Biology, Uppsala University, S-75124 Uppsala, Sweden., Lane DP; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, S-17165 Solna, Sweden., Maia FRNC; Department of Cell and Molecular Biology, Uppsala University, S-75124 Uppsala, Sweden., Linder MB; Bioproducts and Biosystems, Aalto University, Fi-00076 Aalto, Espoo, Finland., Rising A; Department of Anatomy Physiology and Biochemistry, Swedish University of Agricultural Sciences, S-75007 Uppsala, Sweden.; Department of Biosciences and Nutrition, Karolinska Institutet, S-14157 Huddinge, Sweden., Landreh M; Department of Cell and Molecular Biology, Uppsala University, S-75124 Uppsala, Sweden.; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, S-17165 Solna, Sweden.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2024 Jul 17; Vol. 146 (28), pp. 19555-19565. Date of Electronic Publication: 2024 Jul 04.