Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Doyle G. Graham"'
Publikováno v:
Experimental and Clinical Neurotoxicology.
Externí odkaz:
https://doi.org/10.1093/oso/9780195084771.003.0089
Autor:
Doyle G. Graham
Publikováno v:
Medical Science Educator. 22:133-135
After a career of lecturing and giving individual exams, the author presents his experience with Team-LEAD, the adaptation of team-based learning at Duke-NUS Graduate Medical School Singapore. Through struggling as individuals, then in teams, then as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59c5e29fc1ac48718a071317ebf5f006
https://doi.org/10.1007/bf03341774
https://doi.org/10.1007/bf03341774
Publikováno v:
MedEdPublish. 6:72
This article was migrated. The article was not marked as recommended. Background: Students' ability to retain content in medical school has always been a concern. At Duke-NUS Medical School, we modified our Team-Based Learning (TBL) classes known as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1368edd97e0fb0c3ce749bd97edf2286
https://doi.org/10.15694/mep.2017.000072
https://doi.org/10.15694/mep.2017.000072
Autor:
Doyle G. Graham, Venkataraman Amarnath, Matthew J. Picklo, J. Oliver McIntyre, Thomas J. Montine
Publikováno v:
Journal of Neurochemistry. 72:1617-1624
A destructive cycle of oxidative stress and mitochondrial dysfunction is proposed in neurodegenerative disease. Lipid peroxidation, one outcome of oxidative challenge, can lead to the formation of 4-hydroxy-2(E)-nonenal (HNE), a lipophilic alkenal th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55cc66a9818c730549ba745b8c3fb8c3
https://doi.org/10.1046/j.1471-4159.1999.721617.x
https://doi.org/10.1046/j.1471-4159.1999.721617.x
Autor:
Thomas J. Montine, Doyle G. Graham, Matthew J. Picklo, Jing Zhang, Vladimir Kravtsov, Venkataraman Amarnath
Publikováno v:
Journal of Neurochemistry. 74:970-978
The mechanisms that underlie dopaminergic neurodegeneration in Parkinson's disease (PD) are not known but have been proposed to involve oxidation of dopamine and related catechols. In other organ systems, cytotoxicity from catechol oxidation is profo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271cf9d649060588338ec85f23425a7c
https://doi.org/10.1046/j.1471-4159.2000.0740970.x
https://doi.org/10.1046/j.1471-4159.2000.0740970.x
Autor:
Doyle G. Graham, V. Amarnath, Matthew J. Picklo, Kathrin R. Sidell, Jing Zhang, Thomas J. Montine
Publikováno v:
Drug Metabolism Reviews. 32:363-376
Pathological and biochemical studies have consistently associated endogenous catechol oxidation with dopaminergic neurodegeneration in Parkinson's disease (PD). Recently, it has been proposed that products of catechol oxidation, the catechol thioethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b28eb2a1af5ab645fe1997cf94d913b
https://doi.org/10.1081/dmr-100102339
https://doi.org/10.1081/dmr-100102339
Autor:
Doyle G. Graham
Publikováno v:
Current Opinion in Neurology. 12:733-737
Exposure to occupational and environmental toxicants can result in distal axonopathies through reaction with various components of the axonal cytoskeleton. The solvents n-hexane and methyl n-butyl ketone are metabolized to the beta-diketone, 2,5-hexa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f115d2416b7b4f0ff4234cdd3ab78f3a
https://doi.org/10.1097/00019052-199912000-00013
https://doi.org/10.1097/00019052-199912000-00013
Autor:
Larry L. Swift, Jason D. Morrow, Kathleen S. Montine, L. Jackson Roberts, Doyle G. Graham, Sergio Fazio, Sandra J. Olson, Thomas J. Montine, MacRae F. Linton
Publikováno v:
Experimental Neurology. 158:234-241
Aged homozygous apolipoprotein E gene-deficient (apoE -/-) mice have been proposed as an experimental model for the role of human apoE isoforms in Alzheimer's disease (AD). However, results from different laboratories have been in conflict regarding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900b7a64a15f7f31c3216588b430325c
https://doi.org/10.1006/exnr.1999.7067
https://doi.org/10.1006/exnr.1999.7067
Autor:
William M. Valentine, R W Morris, J G Lewis, Robert C. Sills, Doyle G. Graham, Daniel L. Morgan
Publikováno v:
Toxicological Sciences. 49:124-132
Even though atherosclerotic cardiovascular disease (ACVD) is the number one cause of death in the United States, the effects of environmental toxicants on this process are less well studied than the effects of chemicals on the second leading cause of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f086cd97c30e937ece2a8ed8206f1b9
https://doi.org/10.1093/toxsci/49.1.124
https://doi.org/10.1093/toxsci/49.1.124
Secondary Excitotoxicity Contributes to Dopamine-Induced Apoptosis of Dopaminergic Neuronal Cultures
Publikováno v:
Biochemical and Biophysical Research Communications. 248:812-816
Dopamine (DA) and related catechols may contribute to selective degeneration of dopaminergic neurons in the substantia nigra in Parkinson's disease. To investigate whether DA induces apoptosis of dopaminergic neurons, we characterized the effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9501c7565737b8f0c49531cec99778
https://doi.org/10.1006/bbrc.1998.9044
https://doi.org/10.1006/bbrc.1998.9044