Zobrazeno 1 - 10
of 478
pro vyhledávání: '"Doxorubicin induced cardiomyopathy"'
Autor:
Jingxuan Cui, Yujia Chen, Qiannan Yang, Peng Zhao, Mian Yang, Xiaoqi Wang, Ge Mang, Xiangyu Yan, Di Wang, Zhonghua Tong, Penghe Wang, Yingjin Kong, Naixin Wang, Dongni Wang, Nana Dong, Mingyang Liu, Mingyan E, Maomao Zhang, Bo Yu
Publikováno v:
Advanced Science, Vol 11, Iss 34, Pp n/a-n/a (2024)
Abstract Doxorubicin (DOX) is an effective anticancer agent, but its clinical utility is constrained by dose‐dependent cardiotoxicity, partly due to cardiomyocyte ferroptosis. However, the progress of developing cardioprotective medications to coun
Externí odkaz:
https://doaj.org/article/960e1c67a3ba480fb70fcde1748f6187
Autor:
Dimitris Kounatidis, Natalia G. Vallianou, Irene Karampela, Eleni Rebelos, Marina Kouveletsou, Vasileios Dalopoulos, Petros Koufopoulos, Evanthia Diakoumopoulou, Nikolaos Tentolouris, Maria Dalamaga
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1479 (2024)
Diabetes mellitus (DM) is a significant risk factor for various cancers, with the impact of anti-diabetic therapies on cancer progression differing across malignancies. Among these therapies, metformin has gained attention for its potential anti-canc
Externí odkaz:
https://doaj.org/article/2c5261fefe1248bb8c58a6e53519538a
Autor:
Qingling Zhang, Yunpeng Zhang, Bingxin Xie, Daiqi Liu, Yueying Wang, Zandong Zhou, Yue Zhang, Emma King, Gary Tse, Tong Liu
Publikováno v:
Cancer Innovation, Vol 2, Iss 4, Pp 253-264 (2023)
Abstract Background Doxorubicin is a widely used cytotoxic chemotherapy agent for treating different malignancies. However, its use is associated with dose‐dependent cardiotoxicity, causing irreversible myocardial damage and significantly reducing
Externí odkaz:
https://doaj.org/article/0e82b31006ed4c1582433c80882e27d5
Publikováno v:
BMC Pharmacology and Toxicology, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background The severe unfavorable effects of doxorubicin on the heart restrict its clinical usage. Numerous investigations document that cyclic GMP-AMP synthase (cGAS) activator of interferon genes (STING) cascade influences inflammation alo
Externí odkaz:
https://doaj.org/article/622c49fc8112464da806d7ed49248253
Akademický článek
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Publikováno v:
BMC Cardiovascular Disorders, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Doxorubicin (DOX) has limited chemotherapy application for malignancies due to cardiotoxicity. The pathogenesis of DOX-induced cardiomyopathy (DiCM) is yet to be elucidated. Increasing studies proved that activation of AKT prevent
Externí odkaz:
https://doaj.org/article/a1a262ecc80146d6aeb48f949f3a1a33
Akademický článek
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Akademický článek
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Publikováno v:
Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background The chemotherapy drug doxorubicin (Dox) is widely used for treating a variety of cancers. However, its high cardiotoxicity hampered its clinical use. Exosomes derived from stem cells showed a therapeutic effect against Dox-induced
Externí odkaz:
https://doaj.org/article/7a60b83c53db4187ad89ecb9891e36fd
Publikováno v:
Biomedicines, Vol 10, Iss 4, p 890 (2022)
The use of doxorubicin (Dox) in cancer patients carries the risk of cardiotoxicity via an increase in oxidative stress, mitochondrial dysfunction, and disturbed endoplasmic reticulum (ER) homeostasis in cardiomyocytes. The present study explores whic
Externí odkaz:
https://doaj.org/article/0ff435f058f5467cb1e9fd3e2f7879d2