Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Dox, doxycycline"'
Autor:
Ying Yan, Chitra Palanivel, Charles A. Enke, Geoffrey A. Talmon, Nichole D. Brandquist, Keith R. Johnson, Lepakshe S. V. Madduri, Michael J. Baine, Sumin Zhou, Michel M. Ouellette
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1192-1203 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
We have previously reported an important role of PR55α, a regulatory subunit of PP2A Ser/Thr phosphatase, in the support of critical oncogenic pathways required for oncogenesis and the malignant phenotype of pancreatic cancer. The studies in this re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f832db5958c0092cf4988a30bef03318
http://www.sciencedirect.com/science/article/pii/S1476558621000877
http://www.sciencedirect.com/science/article/pii/S1476558621000877
Autor:
Anaïs F. Bardet, Daniel Hess, Daniel Olivieri, Sébastien A. Smallwood, Ulrich Elling, Sujani Paramanathan, Joerg Betschinger
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (2), pp.100947. ⟨10.1016/j.jbc.2021.100947⟩
The Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (2), pp.100947. ⟨10.1016/j.jbc.2021.100947⟩
The Journal of Biological Chemistry
Transcription factors (TFs) harboring broad-complex, tramtrack, and bric-a-brac (BTB) domains play important roles in development and disease. These BTB domains are thought to recruit transcriptional modulators to target DNA regions. However, a syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026739c7c937a26878c6cad73fcd7ad9
Autor:
Tomohide Kurahashi, Satoshi Ogura, Takahiro Kodama, Yoshihiro Kamada, I-Ching Wang, Ryotaro Sakamori, Yuichiro Doki, Eiichi Morii, Kunimaro Furuta, Mayumi Egawa, Masaki Mori, Yuichi Yoshida, Hidetoshi Eguchi, Tomohide Tatsumi, Tetsuo Takehara, Shinichi Kiso, Hayato Hikita, Vladimir V. Kalinichenko
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 425-446 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Liver inflammation has been recognized as a hallmark of hepatocarcinogenesis. Although Forkhead Box M1 (FoxM1) is a well-defined oncogenic transcription factor that is overexpressed in hepatocellular carcinoma (HCC), its role in liv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1403d8cda7ea7dc20a251ac03e8852ad
https://doi.org/10.1016/j.jcmgh.2019.10.008
https://doi.org/10.1016/j.jcmgh.2019.10.008
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 391-418 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims The miR-34a gene is a direct target of p53 and is commonly silenced in colorectal cancer (CRC). Here we identified the receptor tyrosine kinase CSF1R as a direct miR-34a target and characterized CSF1R as an effector of p53/miR-34a-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd6f32982ca09e25e86801417a279b4
http://www.sciencedirect.com/science/article/pii/S2352345X20300461
http://www.sciencedirect.com/science/article/pii/S2352345X20300461
Autor:
Yuting Li, Junxiang Ji, Meng Zhang, Qian Ban, Xinbao Zhang, Xiaoxiao Wang, Yan Zhang, Shou-Dong Ye, Xiaofeng Li, Xin Wang
Publikováno v:
The Journal of Biological Chemistry
Primordial germ cells (PGCs) are common ancestors of all germline cells. However, mechanistic understanding of how PGC specification occurs is limited. Here, we identified transcription factor CP2-like 1 (Tfcp2l1), an important pluripotency factor, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44acb44a05e35b6e07993ad30720ada1
https://pubmed.ncbi.nlm.nih.gov/34555410
https://pubmed.ncbi.nlm.nih.gov/34555410
Autor:
Sayaka Nagata, Go Ito, Kiichiro Tsuchiya, Ryuichi Okamoto, Hiromichi Shimizu, M. Tsuchiya, Ami Kawamoto, Sho Anzai, Yui Hiraguri, Reiko Kuno, Tomohiro Mizutani, Hady Yuki Sugihara, Junichi Takahashi, Shigeru Oshima, Sayaka Takeoka, Shiro Yui, Mamoru Watanabe
Publikováno v:
Biochemistry and Biophysics Reports, Vol 25, Iss, Pp 100906-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Notch signaling is activated in the intestinal epithelial cells (IECs) of patients with inflammatory bowel disease (IBD), and contributes to mucosal regeneration. Our previous study indicated that TNF-α and Notch signaling may synergistically promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e7ac8e21e97f8e18a12df960dcb2be
http://www.sciencedirect.com/science/article/pii/S2405580820302168
http://www.sciencedirect.com/science/article/pii/S2405580820302168
Autor:
Xueying Tian, Bin Zhou
Publikováno v:
The Journal of Biological Chemistry
Site-specific recombinases (SSRs) are invaluable genome engineering tools that have enormously boosted our understanding of gene functions and cell lineage relationships in developmental biology, stem cell biology, regenerative medicine, and multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd835550bfb4c5ce331da13d1125a3f
http://europepmc.org/articles/PMC8050033
http://europepmc.org/articles/PMC8050033
Autor:
Tsutomo Kume, Fred B. Berry, Yawen Hu, Nikola Srnic, Asra Almubarak, Rotem Lavy, Devi Priyanka Maripuri
Publikováno v:
The Journal of Biological Chemistry
Endochondral ossification forms and grows the majority of the mammalian skeleton and is tightly controlled through gene regulatory networks. The forkhead box transcription factorsFoxc1andFoxc2have been demonstrated to regulate aspects of osteoblast f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b60b587dd04ba551feaceb593cb75a4
https://doi.org/10.1101/2021.01.27.428508
https://doi.org/10.1101/2021.01.27.428508
Autor:
Sjoerd J L van Wijk, Simone Fulda, Birte Jeiler, Jens Roedig, Nadezda Dolgikh, Annkathrin Koch
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 5, Pp 539-550 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 5, Pp 539-550 (2021)
Burkitt's lymphoma (BL) is a highly aggressive form of B-cell non-Hodgkin's lymphoma. The clinical outcome in children with BL has improved over the last years but the prognosis for adults is still poor, highlighting the need for novel treatment stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65da807d73e5d104985297a80089959
https://pubmed.ncbi.nlm.nih.gov/33971465
https://pubmed.ncbi.nlm.nih.gov/33971465
Autor:
Tali Gidalevitz, Adrienne W. Paton, Ravi Radhakrishnan, Stephen Tutton, James C. Paton, Ilaria Marrocco, Chih-Hang Anthony Tang, Yair Argon, Krishna Suresh, Chih-Chi Andrew Hu, Daniel M. Blumenthal, Daniela Eletto, Hossein Fazelinia, Daniela Ricci, Mingjie Ying, Deanne Taylor, Sarah Boyle, Lei Qian, Jade Vargas
Publikováno v:
The Journal of Biological Chemistry
The unfolded protein response plays an evolutionarily conserved role in homeostasis, and its dysregulation often leads to human disease, including diabetes and cancer. IRE1α is a major transducer that conveys endoplasmic reticulum stress via biochem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8721b166fa2b7df7464ce116ac50595
http://hdl.handle.net/11386/4797929
http://hdl.handle.net/11386/4797929