Zobrazeno 1 - 10
of 2 412
pro vyhledávání: '"Dox"'
Autor:
Yuan-feng Zhou, Yang Fu, Ze-qun Lai, Hai-ling Xu, Na Shen, Jun Long, Huang Zhang, Yi-fei Dong
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract This study investigated the effects of heat shock protein 22 (HSP22) against doxorubicin (DOX)-induced kidney injury. Mice were randomly assigned to four groups: CON, ad-HSP22, DOX, and ad-HSP22 + DOX. Adeno-associated virus carrying the HSP
Externí odkaz:
https://doaj.org/article/ce1a18729c83409ea7c6d93d4f9d7987
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Ferroptosis, triggered by iron overload and excessive lipid peroxidation, plays a pivotal role in the progression of DOX-induced cardiomyopathy (DIC), and thus limits the use of doxorubicin (DOX) in clinic. Here, we further showed that cardi
Externí odkaz:
https://doaj.org/article/102b7cabe86844e59f2344e309db65bb
Publikováno v:
Journal of Materials Science: Materials in Medicine, Vol 35, Iss 1, Pp 1-9 (2024)
Abstract The objective of the present study was to develop a novel molybdenum disulfide/iron oxide/gold nanorods (MoS2/Fe3O4/GNR) nanocomposite (MFG) with different concentrations of AgNO3 solution (MFG1, MFG2, and MFG3) for topical doxorubicin (DOX)
Externí odkaz:
https://doaj.org/article/720bd1f59dfb471fae0395dad50d2fad
Autor:
Yu Hong, Xinlan Li, Jia Li, Qiuyi He, Manbing Huang, Yubo Tang, Xiao Chen, Jie Chen, Ke-Jing Tang, Chao Wei
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Background Doxorubicin (Dox) is an effective chemotherapeutic drug for various cancers, but its clinical application is limited by severe cardiotoxicity. Dox treatment can transcriptionally activate multiple cardiotoxicity-associated genes i
Externí odkaz:
https://doaj.org/article/c4132cbacef7408a885444a562b86064
Autor:
Yuanyuan Jia, Yuhui Yao, Lingyao Fan, Qiqing Huang, Guohao Wei, Peiliang Shen, Jia Sun, Gaoshuang Zhu, Zhaorui Sun, Chuandong Zhu, Xin Han
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Chemoresistance remains a significant challenge for effective breast cancer treatment which leads to cancer recurrence. CRISPR-directed gene editing becomes a powerful tool to reduce chemoresistance by reprogramming the tumor microenvironmen
Externí odkaz:
https://doaj.org/article/7a6103de8d214d88bda12105e3dddc0b
Autor:
Hongliang Qiu, Sihui Huang, Yuting Liu, Libo Liu, Fengming Guo, Yingying Guo, Dan Li, Xianfeng Cen, Yajie Chen, Meng Zhang, Yan Che, Man Xu, Qizhu Tang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 6, Pp 2581-2597 (2024)
Doxorubicin (DOX)-mediated cardiotoxicity can exacerbate mortality in oncology patients, but related pharmacotherapeutic measures are relatively limited. Ferroptosis was recently identified as a major mechanism of DOX-induced cardiotoxicity. Idebenon
Externí odkaz:
https://doaj.org/article/dfe8996f856d4f6dbc399a77398b3539
Publikováno v:
Acta Poloniae Pharmaceutica, Vol 81, Iss 1, Pp 109-121 (2024)
Background: Colorectal cancer (CRC) is the most common gastrointestinal malignancy. Doxorubicin (DOX) is a widely utilized chemotherapy drug, but its efficacy is limited due to dose-dependent toxicity. Here, we aim to explore the effect of indole-3-c
Externí odkaz:
https://doaj.org/article/0361ff8bab334a7f9a5eac1d172f3dc7
Autor:
Ahmed Soliman, Mohamed Alkafafy, Ehab Yahya Abdelhiee, Maram H Abduljabbar, Suzan Hasan Alotaibi, Noha M. Gamil, Mohamed Aboubakr
Publikováno v:
International Journal of Medical Toxicology and Forensic Medicine, Vol 14, Iss 03 (2024)
Background: Doxorubicin (DOX) is a potent anthracycline chemotherapy agent widely employed to treat various malignancies, such as cancers and this study sought to determine how allicin (ALC) and or L-carnitine (LC) affect DOX-induced cardiotoxicity i
Externí odkaz:
https://doaj.org/article/d73b211283284b2b9a60b8f9db6cf5b6
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundThe protective effects of metformin (Met) against doxorubicin (Dox)-induced cardiotoxicity via potential hypotheses of mechanisms of action with unknown reliability and credibility.ObjectivesThis study aimed to investigate the protective ef
Externí odkaz:
https://doaj.org/article/d3b6010c6a884750948d5baf6b66c9f8
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e32015- (2024)
Background: Non-small cell lung Cancer (NSCLC) persists as a lethal neoplastic manifestation, exhibiting a diminished 5-year survival rate, partially attributable to chemotherapeutic resistance. This investigative endeavor aimed to elucidate the syne
Externí odkaz:
https://doaj.org/article/962bf5edf66149fca03855c559fba6d4