Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells.

Autor: Tracy MA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195., Lee MB; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195., Hearn BL; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195., Dowsett IT; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195., Thurber LC; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195., Loo J; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195., Loeb AM; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195., Preston K; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195., Tuncel MI; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195., Ghodsian N; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195., Bode A; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195., Tang TT; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195., Chia AR; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195., Herr AJ; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195 alanherr@uw.edu.

Publikováno v: Genetics [Genetics] 2020 Aug; Vol. 215 (4), pp. 959-974. Date of Electronic Publication: 2020 Jun 08.

Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes.

Autor: Lee MB; Department of Pathology, University of Washington, Seattle, WA 98195-7705., Dowsett IT; Department of Pathology, University of Washington, Seattle, WA 98195-7705.; Molecular Medicine and Mechanisms of Disease Program, University of Washington, Seattle, WA 98195-7705., Carr DT; Department of Pathology, University of Washington, Seattle, WA 98195-7705., Wasko BM; Department of Pathology, University of Washington, Seattle, WA 98195-7705.; Department of Biology and Biotechnology, University of Houston-Clear Lake, Houston, TX 77058., Stanton SG; Department of Pathology, University of Washington, Seattle, WA 98195-7705., Chung MS; Department of Pathology, University of Washington, Seattle, WA 98195-7705., Ghodsian N; Department of Pathology, University of Washington, Seattle, WA 98195-7705., Bode A; Department of Pathology, University of Washington, Seattle, WA 98195-7705., Kiflezghi MG; Department of Pathology, University of Washington, Seattle, WA 98195-7705.; Molecular Medicine and Mechanisms of Disease Program, University of Washington, Seattle, WA 98195-7705., Uppal PA; Department of Pathology, University of Washington, Seattle, WA 98195-7705., Grayden KA; Department of Pathology, University of Washington, Seattle, WA 98195-7705., Elala YC; Department of Pathology, University of Washington, Seattle, WA 98195-7705., Tang TT; Department of Pathology, University of Washington, Seattle, WA 98195-7705., Tran NHB; Department of Pathology, University of Washington, Seattle, WA 98195-7705., Tran THB; Department of Pathology, University of Washington, Seattle, WA 98195-7705., Diep AB; Department of Pathology, University of Washington, Seattle, WA 98195-7705., Hope M; Department of Pathology, University of Washington, Seattle, WA 98195-7705., Promislow DEL; Department of Pathology, University of Washington, Seattle, WA 98195-7705.; Department of Biology, University of Washington, Seattle, WA, 98195-1800., Kennedy SR; Department of Pathology, University of Washington, Seattle, WA 98195-7705., Kaeberlein M; Department of Pathology, University of Washington, Seattle, WA 98195-7705., Herr AJ; Department of Pathology, University of Washington, Seattle, WA 98195-7705; alanherr@uw.edu.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Feb 19; Vol. 116 (8), pp. 3062-3071. Date of Electronic Publication: 2019 Feb 04.

Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.

Autor: Soriano, Ignacio^1,2 (AUTHOR) ignacio.soriano@igmm.ed.ac.uk, Vazquez, Enrique³ (AUTHOR), De Leon, Nagore^1,2 (AUTHOR), Bertrand, Sibyl¹ (AUTHOR), Heitzer, Ellen⁴ (AUTHOR), Toumazou, Sophia^1,5 (AUTHOR), Bo, Zhihan¹ (AUTHOR), Palles, Claire⁶ (AUTHOR), Pai, Chen-Chun⁵ (AUTHOR), Humphrey, Timothy C.⁵ (AUTHOR), Tomlinson, Ian² (AUTHOR), Cotterill, Sue⁷ (AUTHOR), Kearsey, Stephen E.¹ (AUTHOR) ignacio.soriano@igmm.ed.ac.uk

Publikováno v: PLoS Genetics. 7/6/2021, Vol. 17 Issue 7, p1-27. 27p.

A modified fluctuation assay reveals a natural mutator phenotype that drives mutation spectrum variation within Saccharomyces cerevisiae.

Autor: Pengyao Jiang, Ollodart, Anja R., Sudhesh, Vidha, Herr, Alan J., Dunham, Maitreya J., Harris, Kelley

Publikováno v: eLife; 10/7/2021, p1-24, 24p

THE LAW AND THE LEGAL PROFESSION--EXPECTATIONS AND REALITY.

Autor: Dowsett, Justice John

Publikováno v: James Cook University Law Review. 2004, Vol. 11, p4-20. 17p.