Posttranscriptional Regulation of 14q32 MicroRNAs by the CIRBP and HADHB during Vascular Regeneration after Ischemia

Autor: Angela Downie Ruiz Velasco, Sabine M.J. Welten, Eveline A.C. Goossens, Paul H.A. Quax, Juri Rappsilber, Gracjan Michlewski, A. Yaël Nossent

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 14, Iss , Pp 329-338 (2019)

After induction of ischemia in mice, 14q32 microRNAs are regulated in three distinct temporal patterns. These expression patterns, as well as basal expression levels, are independent of the microRNA genes’ order in the 14q32 locus. This implies tha

Externí odkaz: https://doaj.org/article/49355aa60c26423686622c16118da574

Comparative effects of viral-transport-medium heat inactivation upon downstream SARS-CoV-2 detection in patient samples

Autor: Andrew V. Benest, Gemma Clarke, Vicki M. Fleming, Sarah Walsh, Hannah C. Howson-Wells, Rebecca Tarbox, Jamie L. Thompson, Manjinder Khakh, Alice Cardall, Nichola Duckworth, Tim J. Sloan, Jaineeta Richardson, Michelle Lister, Chris Denning, C. Patrick McClure, Angela Downie Ruiz Velasco, Claire Seedhouse

Publikováno v: Journal of Medical Microbiology

Introduction. The COVID-19 pandemic, which began in 2020 is testing economic resilience and surge capacity of healthcare providers worldwide. At the time of writing, positive detection of the SARS-CoV-2 virus remains the only method for diagnosing CO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b4fe2ef8e7a979cfc2e5c8394c8332
https://pubmed.ncbi.nlm.nih.gov/33734960

Posttranscriptional Regulation of 14q32 microRNAs by RNA Binding Proteins CIRBP and HADHB during Vascular Regeneration after Ischemia:Posttranscriptional regulation of 14q32 microRNAs

Autor: Downie Ruiz Velasco, Angela, Welten, Sabine M.J., Goossens, Eveline A.C., Quax, Paul H. A., Rappsilber, Juri, Michlewski, Gracjan, Nossent, A. Yael

Publikováno v: Downie Ruiz Velasco, A, Welten, S M J, Goossens, E A C, Quax, PH A, Rappsilber, J, Michlewski, G & Nossent, A Y 2018, ' Posttranscriptional Regulation of 14q32 microRNAs by RNA Binding Proteins CIRBP and HADHB during Vascular Regeneration after Ischemia : Posttranscriptional regulation of 14q32 microRNAs ', Molecular Therapy . https://doi.org/10.1016/j.omtn.2018.11.017

After induction of ischemia in mice, 14q32 microRNAs are regulated in three distinct temporal patterns. These expression patterns, as well as basal expression levels, are independent of the miR genes’ order in the 14q32 locus. This implies that pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::b3fdbe6258a5297b2a6cde66c7071bb7
https://www.pure.ed.ac.uk/ws/files/77734376/1_s2.0_S2162253118303135_main.pdf

Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively

Autor: Nowak, Jakub Stanislaw, Hobor, Fruzsina, Downie Ruiz Velasco, Angela, Choudhury, Nila Roy, Heikel, Gregory, Kerr, Alastair, Ramos, Andres, Michlewski, Gracjan

Lin28a inhibits the biogenesis of let-7 miRNAs by triggering the polyuridylation and degradation of their precursors by terminal uridylyltransferases TUT4/7 and 3'-5' exoribonuclease Dis3l2, respectively. Previously, we showed that Lin28a also contro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d5e353e6424af87dabf9e07c6af311b
https://europepmc.org/articles/PMC5311490/

Comparative effects of viral-transport-medium heat inactivation upon downstream SARS-CoV-2 detection in patient samples.

Autor: Thompson JL; Division of Cancer and Stem Cells, Biodiscovery Institute, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK., Downie Ruiz Velasco A; School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK., Cardall A; Division of Child Health, Obstetrics & Gynaecology, Biodiscovery Institute, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK., Tarbox R; Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Royal Derby Hospital, Nottingham, DE22 3DT, UK., Richardson J; Clinical Microbiology, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK., Clarke G; Clinical Microbiology, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK., Lister M; Clinical Microbiology, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK., Howson-Wells HC; Clinical Microbiology, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK., Fleming VM; Clinical Microbiology, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK., Khakh M; Clinical Microbiology, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK., Sloan T; Path Links Pathology, Northern Lincolnshire and Goole NHS Foundation Trust, Grimbsy, DN33 2BA, UK., Duckworth N; Path Links Pathology, Northern Lincolnshire and Goole NHS Foundation Trust, Grimbsy, DN33 2BA, UK., Walsh S; Path Links Pathology, Northern Lincolnshire and Goole NHS Foundation Trust, Grimbsy, DN33 2BA, UK., Denning C; Division of Cancer and Stem Cells, Biodiscovery Institute, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK., McClure CP; NIHR Nottingham Digestive Diseases Biomedical Research Centre and School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK., Benest AV; Division of Cancer and Stem Cells, Biodiscovery Institute, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK., Seedhouse CH; Division of Cancer and Stem Cells, Biodiscovery Institute, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK.

Publikováno v: Journal of medical microbiology [J Med Microbiol] 2021 Mar; Vol. 70 (3). Date of Electronic Publication: 2021 Mar 18.