Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Downes, DJ"'
Autor:
Truch, J, Downes, DJ, Scott, C, Gür, ER, Telenius, JM, Repapi, E, Schwessinger, R, Gosden, M, Brown, JM, Taylor, S, Cheong, PL, Hughes, JR, Higgs, DR, Gibbons, RJ
Publikováno v:
Nature Communications. 13
The chromatin remodeller ATRX interacts with the histone chaperone DAXX to deposit the histone variant H3.3 at sites of nucleosome turnover. ATRX is known to bind repetitive, heterochromatic regions of the genome including telomeres, ribosomal DNA an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4843ffce4bace57b3a9539da1548ca
https://doi.org/10.1038/s41467-022-31194-7
https://doi.org/10.1038/s41467-022-31194-7
Autor:
Simon, CS, Downes, DJ, Gosden, ME, Telenius, J, Higgs, DR, Hughes, JR, Costello, I, Bikoff, EK, Robertson, E
The T-box transcription factor (TF) Eomes is a key regulator of cell fate decisions during early mouse development. The cis-acting regulatory elements that direct expression in the anterior visceral endoderm (AVE), primitive streak (PS) and definitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::602fc931882bda48f68372ca7d4cf630
https://doi.org/10.1242/dev.147322
https://doi.org/10.1242/dev.147322
Autor:
Daniels DE; School of Biochemistry, University of Bristol, Bristol, UK; NIHR Blood and Transplant Research Unit, University of Bristol, Bristol, UK., Downes DJ; MRC Molecular Haematology Unit, MRC Weathe-rall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Ferrer-Vicens I; School of Biochemistry, University of Bristol, Bristol, UK., Ferguson DCJ; School of Biochemistry, University of Bristol, Bristol, UK., Singleton BK; NIHR Blood and Transplant Research Unit, University of Bristol, Bristol, UK; Bristol Institute for Transfusion Sciences, National Health Service Blood and Transplant (NHSBT), Bristol, UK., Wilson MC; School of Biochemistry, University of Bristol, Bristol, UK., Trakarnsanga K; Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Kurita R; Department of Research and Development, Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan., Nakamura Y; Cell Engineering Division, RIKEN BioResource Research Center, Ibaraki, Japan., Anstee DJ; NIHR Blood and Transplant Research Unit, University of Bristol, Bristol, UK; Bristol Institute for Transfusion Sciences, National Health Service Blood and Transplant (NHSBT), Bristol, UK., Frayne J; School of Biochemistry, University of Bristol, Bristol, UK; NIHR Blood and Transplant Research Unit, University of Bristol, Bristol, UK. jan.frayne@bristol.ac.uk.
Publikováno v:
Haematologica [Haematologica] 2024 Jan 01; Vol. 109 (1), pp. 364. Date of Electronic Publication: 2024 Jan 01.
Autor:
Downes DJ; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Smith AL; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Karpinska MA; Max Planck Institute for Biophysical Chemistry, Göttingen, Germany., Velychko T; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany., Rue-Albrecht K; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Sims D; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Milne TA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Haematology Theme, Oxford, UK., Davies JOJ; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Oudelaar AM; Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. marieke.oudelaar@mpibpc.mpg.de., Hughes JR; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. jim.hughes@imm.ox.ac.uk.; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. jim.hughes@imm.ox.ac.uk.
Publikováno v:
Nature protocols [Nat Protoc] 2023 Oct; Vol. 18 (10), pp. 3155.
Autor:
Torres JM; Wellcome Centre for Human Genetics, University of Oxford, Oxford, England, OX3 7BN, UK., Sun H; Department of Pediatrics, Division of Endocrinology and Diabetes, Stanford University School of Medicine, Stanford, CA, 94305, USA., Nylander V; Oxford Centre for Diabetes Endocrinology & Metabolism, University of Oxford, Oxford, England, OX3 7L3, UK., Downes DJ; Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9D2, UK., van de Bunt M; Wellcome Centre for Human Genetics, University of Oxford, Oxford, England, OX3 7BN, UK.; Oxford Centre for Diabetes Endocrinology & Metabolism, University of Oxford, Oxford, England, OX3 7L3, UK.; Present address: Cytoki Pharma ApS, Tuborg Boulevard 12, Hellerup, DK-2900, Denmark., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, England, OX3 7BN, UK.; Oxford Centre for Diabetes Endocrinology & Metabolism, University of Oxford, Oxford, England, OX3 7L3, UK.; Present address: OMNI Human Genetics, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Hughes JR; Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9D2, UK.; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9D2, UK., Gloyn AL; Wellcome Centre for Human Genetics, University of Oxford, Oxford, England, OX3 7BN, UK.; Department of Pediatrics, Division of Endocrinology and Diabetes, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Oxford Centre for Diabetes Endocrinology & Metabolism, University of Oxford, Oxford, England, OX3 7L3, UK.
Publikováno v:
Wellcome open research [Wellcome Open Res] 2023 Aug 08; Vol. 8, pp. 165. Date of Electronic Publication: 2023 Aug 08 (Print Publication: 2023).
Autor:
Hentges LD; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Sergeant MJ; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Cole CB; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Downes DJ; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Hughes JR; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Taylor S; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Publikováno v:
Bioinformatics (Oxford, England) [Bioinformatics] 2022 Sep 15; Vol. 38 (18), pp. 4255-4263.
Autor:
Downes DJ; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; email: damien.downes@ndcls.ox.ac.uk., Hughes JR; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; email: damien.downes@ndcls.ox.ac.uk.; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; email: jim.hughes@imm.ox.ac.uk.
Publikováno v:
Annual review of genomics and human genetics [Annu Rev Genomics Hum Genet] 2022 Aug 31; Vol. 23, pp. 73-97. Date of Electronic Publication: 2022 Apr 26.
Autor:
Owens DDG; MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada., Anselmi G; MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Oudelaar AM; MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Max Planck Institute for Biophysical Chemistry, Göttingen, Germany., Downes DJ; MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Cavallo A; MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Harman JR; MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Schwessinger R; MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Bucakci A; MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Greder L; MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., de Ornellas S; MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Physical and Theoretical Chemistry Building, Department of Chemistry, University of Oxford, Oxford, UK., Jeziorska D; MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Telenius J; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Hughes JR; MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. jim.hughes@imm.ox.ac.uk.; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. jim.hughes@imm.ox.ac.uk., de Bruijn MFTR; MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. marella.debruijn@imm.ox.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2022 Feb 09; Vol. 13 (1), pp. 773. Date of Electronic Publication: 2022 Feb 09.
Autor:
Downes DJ; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Smith AL; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Karpinska MA; Max Planck Institute for Biophysical Chemistry, Göttingen, Germany., Velychko T; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany., Rue-Albrecht K; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Sims D; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Milne TA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Haematology Theme, Oxford, UK., Davies JOJ; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Oudelaar AM; Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. marieke.oudelaar@mpibpc.mpg.de., Hughes JR; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. jim.hughes@imm.ox.ac.uk.; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. jim.hughes@imm.ox.ac.uk.
Publikováno v:
Nature protocols [Nat Protoc] 2022 Feb; Vol. 17 (2), pp. 445-475. Date of Electronic Publication: 2022 Feb 04.
Autor:
Oudelaar AM; Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. marieke.oudelaar@mpinat.mpg.de., Downes DJ; MRC Molecular Haematology Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Hughes JR; MRC Molecular Haematology Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Publikováno v:
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2532, pp. 95-112.