Výsledky vyhledávání - "Down-Regulation/genetics"

Transcriptional profile of cytokines, regulatory mediators and tlr in mesenchymal stromal cells after inflammatory signaling and cell-passaging

Autor: Robim Marcelino Rodrigues, Makram Merimi, Vera Rogiers, Philippe Lewalle, Laurence Lagneaux, Dhouha Daassi, Rahma Melki, Karolien Buyl, Hassan Fahmi, Mehdi Najar, Joery De Kock, Tamara Vanhaecke

Publikováno v: International journal of molecular sciences, 22 (14
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 7309, p 7309 (2021)

Adult human subcutaneous adipose tissue (AT) harbors a rich population of mesenchymal stromal cells (MSCs) that are of interest for tissue repair. For this purpose, it is of utmost importance to determine the response of AT-MSCs to proliferative and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d18997972040e04c455d4d25438cdc
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/329221

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Identification of a functional FADS1 3′UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels

Autor: Xavier Hermant, Amandine Flaig, Dominique Cottel, Gilbert Briand, Brigitte Laillet, Chantal Simon, Aline Meirhaeghe, Marie-Adélaïde Bout, Julie Dumont, Dominique Arveiler, Aline Wagner, Jean Dallongeville, Charlotte Delay, Jean-Bernard Ruidavets, Jimena Luque-Bedregal, Jean Ferrières, Philippe Amouyel

Publikováno v: Journal of clinical lipidology
Journal of clinical lipidology, Elsevier, 2018, 12 (5), pp.1280--1289. ⟨10.1016/j.jacl.2018.07.012⟩
Journal of clinical lipidology, 2018, 12 (5), pp.1280--1289. ⟨10.1016/j.jacl.2018.07.012⟩

International audience; BACKGROUND: Blood polyunsaturated fatty acid (PUFA) levels are determined by diet and by endogenous synthesis via Delta 5- and Delta 6-desaturases (encoded by the FADS] and FADS2 genes, respectively). Genome-wide association s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776b9882168384015577c4c64face99e
https://doi.org/10.1016/j.jacl.2018.07.012

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Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis

Autor: Kuroki, S., Nakai, Y., Maeda, R., Okashita, N., Akiyoshi, M., Yamaguchi, Y., Kitano, S., Miyachi, H., Nakato, R., Ichiyanagi, K., Shirahige, K., Kimura, Hiroshi, Shinkai, Y., Tachibana, M.

Publikováno v: Stem Cell Reports
Stem Cell Reports, Vol 10, Iss 4, Pp 1340-1354 (2018)

Summary Histone H3 lysine 9 (H3K9) methylation is unevenly distributed in mammalian chromosomes. However, the molecular mechanism controlling the uneven distribution and its biological significance remain to be elucidated. Here, we show that JMJD1A a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3c1919b43481572150b59f55092c82
http://europepmc.org/articles/PMC5998703

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Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells

Autor: Kathleen Coddens, Frank Grosveld, Geert Berx, Danny Huylebroeck, Steven Goossens, Annick Francis, Tim Pieters, Agata Stryjewska, Leo A. van Grunsven, Jody J. Haigh, Andrea Conidi, Griet Verstappen, Lieve Umans, Ruben Dries, Wilfred F. J. van IJcken

Publikováno v: Stem Cells (Dayton, Ohio)
Stem Cells, 35(3), 611-625. Wiley-Blackwell
STEM CELLS

In human embryonic stem cells (ESCs) the transcription factor Zeb2 regulates neuroectoderm versus mesendoderm formation, but it is unclear how Zeb2 affects the global transcriptional regulatory network in these cell-fate decisions. We generated Zeb2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51f148d5f4bd8202da29e5f77a153cc
https://pure.eur.nl/en/publications/855396fe-6060-4c05-ad0c-4fcdbe86b1bf

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Key Genes of Lipid Metabolism and WNT-Signaling Are Downregulated in Subcutaneous Adipose Tissue with Moderate Weight Loss

Autor: Tilman Kühn, Mirja Grafetstätter, Ruth Schübel, Rudolf Kaaks, Theron Johnson, Judith Greimel, Disorn Sookthai, Mario Kratz, Cornelia M. Ulrich, Romy Kirsten

Publikováno v: Nutrients
Volume 11
Issue 3
Nutrients, Vol 11, Iss 3, p 639 (2019)
Schübel, R, Sookthai, D, Greimel, J, Johnson, T S, Grafetstätter, M E, Kirsten, R, Kratz, M, Ulrich, C M, Kaaks, R & Kühn, T 2019, ' Key Genes of Lipid Metabolism and WNT-Signaling Are Downregulated in Subcutaneous Adipose Tissue with Moderate Weight Loss ', Nutrients, vol. 11, no. 3 . https://doi.org/10.3390/nu11030639

Smaller cross-sectional studies and bariatric surgery trials suggest that weight loss may change the expression of genes in adipose tissue that have been implicated in the development of metabolic diseases, but well-powered intervention trials are la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f530736e758efe3b282b00b85d3269d
http://europepmc.org/articles/PMC6471921

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The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin

Publikováno v: Brain-A Journal of Neurology
Brain-A Journal of Neurology, Oxford University Press (OUP), 2018, 141 (5), pp.1434-1454. ⟨10.1093/brain/awy057⟩
Brain-A Journal of Neurology, 2018, 141 (5), pp.1434-1454. ⟨10.1093/brain/awy057⟩
Brain
Brain, vol. 141, no. 5, pp. 1434-1454

Expression of the neuronal kinase DCLK3 is reduced in Huntington’s disease. Galvan et al. report that DCLK3 silencing in the mouse striatum exacerbates the toxicity of mutant huntingtin, whereas DCLK3 overexpression is neuroprotective, and show tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::eb0c82958019d7f33356d092f6de6863
https://hal.archives-ouvertes.fr/hal-02459743

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SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3

Autor: Shinchi, Y., Hieda, M., Nishioka, Y., Matsumoto, A., Yokoyama, Y., Kimura, Hiroshi, Matsuura, S., Matsuura, N.

Publikováno v: Experimental Cell Research. 334:90-99

The genome-wide loss of histone H4 lysine 20 tri-methylation (H4K20me3) is observed in multiple types of cancer, including breast tumors. Since H4K20me3 is preferentially targeted to repetitive elements in the pericentromeric and telomeric heterochro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654be7ed0ab2a2b6b8f198a59ee761cf
https://doi.org/10.1016/j.yexcr.2015.03.010

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A genomic screen for angiosuppressor genes in the tumor endothelium identifies a multifaceted angiostatic role for bromodomain containing 7 (BRD7)

Autor: Maaike van Berkel, Patrycja Nowak-Sliwinska, Judy R. van Beijnum, Tse J. Wong, Arjan W. Griffioen

Publikováno v: van Beijnum, J R, Nowak-Sliwinska, P, van Berkel, M, Wong, T J & Griffioen, A W 2017, ' A genomic screen for angiosuppressor genes in the tumor endothelium identifies a multifaceted angiostatic role for bromodomain containing 7 (BRD7) ', Angiogenesis, vol. 20, no. 4, pp. 641-654 . https://doi.org/10.1007/s10456-017-9576-3
Angiogenesis, 20(4), 641-654. Springer Netherlands
Angiogenesis, Vol. 20, No 4 (2017) pp. 641-654
Angiogenesis

Tumor angiogenesis is characterized by deregulated gene expression in endothelial cells (EC). While studies until now have mainly focused on overexpressed genes in tumor endothelium, we here describe the identification of transcripts that are repress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e965f1fb46a3ed6ba68fc13428529fb
https://research.vumc.nl/en/publications/4f373f32-ed02-45ac-8d50-da7ec39a5d09

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Suppression of Tcf1 by Inflammatory Cytokines Facilitates Effector CD8 T Cell Differentiation

Autor: Werner Held, Joana Gomes Silva, Maxime Danilo, Vijaykumar Chennupati, Stefanie Siegert

Publikováno v: Cell Reports, Vol 22, Iss 8, Pp 2107-2117 (2018)
Cell reports, vol. 22, no. 8, pp. 2107-2117

Summary The formation of central CD8 T cell memory in response to infection depends on the transcription factor Tcf1 ( Tcf7 ). Tcf1 is expressed at high levels in naive CD8 T cells but downregulated in most CD8 T cells during effector differentiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d687f76a7d1c441986c1ed7772daac
https://pubmed.ncbi.nlm.nih.gov/29466737

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