5-ALPHA-REDUCTASE-1 KNOCKOUT PROTECTS AGAINST HEPATOCARCINOGENESIS IN A MURINE MODEL OF NASH

Autor: Dowman, JK, Hopkins, LJ, Armstrong, MJ, Gathercole, LL, Lalor, PF, Hubscher, SG, Tomlinson, JW, Newsome, PN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d93de3d1a5b2aca9671f88e4126024bf
https://ora.ox.ac.uk/objects/uuid:b04c5858-6242-4863-b3cf-91f5a024571a

Synbiotics Alter Fecal Microbiomes, But Not Liver Fat or Fibrosis, in a Randomized Trial of Patients With Nonalcoholic Fatty Liver Disease.

Autor: Scorletti E; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom; Department of Gastroenterology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania. Electronic address: e.scorletti@soton.ac.uk., Afolabi PR; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom., Miles EA; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Smith DE; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom., Almehmadi A; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Alshathry A; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Childs CE; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Del Fabbro S; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Bilson J; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom., Moyses HE; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom., Clough GF; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Sethi JK; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom., Patel J; Hepatology, Department of Medicine, University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, United Kingdom., Wright M; Hepatology, Department of Medicine, University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, United Kingdom., Breen DJ; Department of Radiology, University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, United Kingdom., Peebles C; Department of Radiology, University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, United Kingdom., Darekar A; Department of Medical Physics, University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, United Kingdom., Aspinall R; Department of Hepatology, Portsmouth Hospitals National Health Service (NHS) Trust, Queen Alexandra Hospital, Portsmouth, United Kingdom., Fowell AJ; Department of Hepatology, Portsmouth Hospitals National Health Service (NHS) Trust, Queen Alexandra Hospital, Portsmouth, United Kingdom., Dowman JK; Department of Hepatology, Portsmouth Hospitals National Health Service (NHS) Trust, Queen Alexandra Hospital, Portsmouth, United Kingdom., Nobili V; Hepatology, Gastroenterology and Nutrition Unit, Istituto di Ricovero e Cura a Carattere Scientifico 'Bambino Gesù' Children's Hospital, Rome, Italy; Department of Pediatric, University 'La Sapienza', Rome, Italy., Targher G; Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy., Delzenne NM; Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium., Bindels LB; Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium., Calder PC; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom., Byrne CD; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom.

Publikováno v: Gastroenterology [Gastroenterology] 2020 May; Vol. 158 (6), pp. 1597-1610.e7. Date of Electronic Publication: 2020 Jan 25.

Observed high incidence of buried bumper syndrome associated with Freka PEG tubes.

Autor: Dowman JK; Sandwell and West Birmingham NHS Trust, City Hospital, Birmingham, UK., Ditchburn L; Sandwell and West Birmingham NHS Trust, City Hospital, Birmingham, UK., Chapman W; Sandwell and West Birmingham NHS Trust, City Hospital, Birmingham, UK., Lidder P; Sandwell and West Birmingham NHS Trust, Sandwell General Hospital, West Bromwich, UK., Wootton N; Sandwell and West Birmingham NHS Trust, City Hospital, Birmingham, UK., Ryan N; Sandwell and West Birmingham NHS Trust, Sandwell General Hospital, West Bromwich, UK., Cooney RM; Sandwell and West Birmingham NHS Trust, City Hospital, Birmingham, UK.

Publikováno v: Frontline gastroenterology [Frontline Gastroenterol] 2015 Jul; Vol. 6 (3), pp. 194-198. Date of Electronic Publication: 2014 Nov 25.

Loss of 5α-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice.

Autor: Dowman JK; PhD, FRCP, Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TT, United Kingdom. J.W.Tomlinson@bham.ac.uk., Hopkins LJ, Reynolds GM, Armstrong MJ, Nasiri M, Nikolaou N, van Houten EL, Visser JA, Morgan SA, Lavery GG, Oprescu A, Hübscher SG, Newsome PN, Tomlinson JW

Publikováno v: Endocrinology [Endocrinology] 2013 Dec; Vol. 154 (12), pp. 4536-47. Date of Electronic Publication: 2013 Sep 30.

Liver transplantation for acute intermittent porphyria is complicated by a high rate of hepatic artery thrombosis.

Autor: Dowman JK; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom. j.k.dowman@bham.ac.uk, Gunson BK, Mirza DF, Bramhall SR, Badminton MN, Newsome PN

Publikováno v: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society [Liver Transpl] 2012 Feb; Vol. 18 (2), pp. 195-200.