CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120

Autor: Maung, Ricky, Hoefer, Melanie M, Sanchez, Ana B, Sejbuk, Natalia E, Medders, Kathryn E, Desai, Maya K, Catalan, Irene C, Dowling, Cari C, de Rozieres, Cyrus M, Garden, Gwenn A, Russo, Rossella, Roberts, Amanda J, Williams, Roy, Kaul, Marcus

Publikováno v: Journal of immunology (Baltimore, Md. : 1950), vol 193, iss 4

The innate immune system has been implicated in several neurodegenerative diseases, including HIV-1-associated dementia. In this study, we show that genetic ablation of CCR5 prevents microglial activation and neuronal damage in a transgenic model of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::a1b7d7721e316fceb2c18a23d454d760
https://escholarship.org/uc/item/5pb738q6

Antiretrovirals, Methamphetamine, and HIV-1 Envelope Protein gp120 Compromise Neuronal Energy Homeostasis in Association with Various Degrees of Synaptic and Neuritic Damage

Autor: Sanchez, Ana B., Varano, Giuseppe P., de Rozieres, Cyrus M., Maung, Ricky, Catalan, Irene C., Dowling, Cari C., Sejbuk, Natalia E., Hoefer, Melanie M., Kaul, Marcus

Publikováno v: Antimicrobial Agents and Chemotherapy; October 2015, Vol. 60 Issue: 1 p168-179, 12p

CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120.

Autor: Maung R; Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037;, Hoefer MM; Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037;, Sanchez AB; Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037;, Sejbuk NE; Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037;, Medders KE; Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037; Neuroscience, Aging and Stem Cell Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037;, Desai MK; Neuroscience, Aging and Stem Cell Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037;, Catalan IC; Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037;, Dowling CC; Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037;, de Rozieres CM; Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037;, Garden GA; Department of Neurology, University of Washington, Seattle, WA 98195;, Russo R; Neuroscience, Aging and Stem Cell Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037; Department of Pharmacobiology, University of Calabria, 87036 Arcavacata di Rende, Italy;, Roberts AJ; Molecular and Cellular Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037;, Williams R; Bioinformatics Shared Resource, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037; and., Kaul M; Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037; Neuroscience, Aging and Stem Cell Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037; Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 mkaul@sanfordburnham.org.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2014 Aug 15; Vol. 193 (4), pp. 1895-910. Date of Electronic Publication: 2014 Jul 16.