Zobrazeno 1 - 10
of 306
pro vyhledávání: '"Doweyko, A."'
Aim and research questions: The study examined how text comprehension of middle school students in Sweden changed depending on the modalities of reading and speech synthesis. Impact on the outcome based on factors such as decoding ability, working me
Externí odkaz:
http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-103635
Aim and research questions: The study examined how text comprehension of middle school students in Sweden changed depending on the modalities of reading and speech synthesis. Impact on the outcome based on factors such as decoding ability, working me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______681::cf0bff47f3fdb413b52f14115a4b29d4
http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-103635
http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-103635
Autor:
Johnson, Stephen R., Yue, Hongwen, Conder, Mary Lee, Shi, Hong, Doweyko, Arthur M., Lloyd, John, Levesque, Paul
Publikováno v:
In Bioorganic & Medicinal Chemistry 2007 15(18):6182-6192
Autor:
Gregory D. Vite, Paul A. Elzinga, David L. Gold, Cheryl A. Rizzo, Thomas E. Spires, Sophie Beyer, Vanessa M. Spires, Marco M. Gottardis, George L. Trainor, Aberra Fura, Audris Huang, Gordon Todderud, John A. Newitt, Lata Jayaraman, Aaron Balog, Andrew J. Tebben, Yongxin Zhu, Mary T. Obermeier, Goodenough Angela, Bethanne M. Warrack, Arthur M. Doweyko, Yi Fan
Publikováno v:
ACS Medicinal Chemistry Letters. 7:40-45
Efforts to identify a potent, reversible, nonsteroidal CYP17A1 lyase inhibitor with good selectivity over CYP17A1 hydroxylase and CYPs 11B1 and 21A2 for the treatment of castration-resistant prostate cancer (CRPC) culminated in the discovery of BMS-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d9351633fecd0f6648e90171669cc3
https://doi.org/10.1021/acsmedchemlett.5b00310
https://doi.org/10.1021/acsmedchemlett.5b00310
Autor:
Carrie Xu, George C. Morton, Vinayak Hosagrahara, Shung Wu, Denis E. Ryono, Jonathan Lippy, Narayanan Hariharan, Kenneth T. Locke, Xiang-Xang Ye, Wei Wang, Liqun Gu, Yi-Xin Li, Fucheng Qu, Peter T. W. Cheng, Sean S. Chen, Kevin O’Malley, Michael Cap, Robert Zahler, Tao Wang, Lori Kunselman, Charles Z. Ding, Cuixia Chu, Rebecca A. Smirk, Neil Flynn, Pratik Devasthale, Hao Zhang, Nathan Morgan, Atsu Apedo, Thomas Harrity, Lisa Zhang, Dennis Farrelly, Arthur M. Doweyko, Zhi Lai, Tim Herpin, Pathanjali Kadiyala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1196-1205
The design, synthesis and structure–activity relationships of a novel series of 3,4-disubstituted pyrrolidine acid analogs as PPAR ligands is outlined. In both the 1,3- and 1,4-oxybenzyl pyrrolidine acid series, the preferred stereochemistry was sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9c9221e9206ed0e57f44f10281d7ab
https://doi.org/10.1016/j.bmcl.2015.01.066
https://doi.org/10.1016/j.bmcl.2015.01.066
Autor:
Robert M. Townsend, Hai Yun Xiao, Joel C. Barrish, Sium Habte, Arthur M. Doweyko, Steven G. Nadler, Hua Gong, Bingwei V. Yang, John H. Dodd, Tram N. Huynh, John E. Somerville, Mark D. Cunningham, Lorraine I. McKay, David J. Shuster, Michele McMahon, David S. Weinstein, Lidia M. Doweyko, Wayne Vaccaro, Deborah A. Holloway
Publikováno v:
Journal of Medicinal Chemistry. 53:8241-8251
A series of 2,2-dimethyl-3,3-diphenyl-propanamides as novel glucocorticoid receptor modulators is reported. SAR exploration led to the identification of 4-hydroxyphenyl propanamide derivatives displaying good agonist activity in GR-mediated transrepr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e18337b275f845f960a3b529ed7e13f
https://doi.org/10.1021/jm100957a
https://doi.org/10.1021/jm100957a
Autor:
Lidia M. Doweyko, Arthur M. Doweyko
Publikováno v:
Future Medicinal Chemistry. 1:1029-1036
Humankind has been in the business of discovering drugs for thousands of years. At present, small-molecule drug design is based on specific macromolecular receptors as targets for inhibition or modulation. To this end, a number of clever approaches h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1fb37fcd4a0f0ef4d61378b4d3fad7
https://doi.org/10.4155/fmc.09.72
https://doi.org/10.4155/fmc.09.72
Autor:
Joel C. Barrish, Aberra Fura, Guoxiang Shen, Jingwu Duan, David S. Nirschl, Jonathan Lippy, Stephen T. Wrobleski, Rosemary Zhang, Lidia M. Doweyko, Bingwei V. Yang, Lauren Haque, Murray McKinnon, Shuqun Lin, Luisa Salter-Cid, Sidney Pitt, William J. Pitts, Percy H. Carter, John S. Sack, Gary L. Schieven, Bin Jiang, John Hynes, Gregory D. Brown, John S. Tokarski, Zhonghui Lu, Javed Khan, Steven G. Nadler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5721-5726
A new class of Janus kinase (JAK) inhibitors was discovered using a rationally designed pyrrolo[1,2-b]pyridazine-3-carboxamide scaffold. Preliminary studies identified (R)-(2,2-dimethylcyclopentyl)amine as a preferred C4 substituent on the pyrrolopyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7f63858a17538ff6a98f0ae52d3f8e
https://doi.org/10.1016/j.bmcl.2014.10.061
https://doi.org/10.1016/j.bmcl.2014.10.061
Autor:
Doweyko, Arthur M.1 arthur.doweyko@bms.com
Publikováno v:
Journal of Computer-Aided Molecular Design. Feb2008, Vol. 22 Issue 2, p81-89. 9p. 3 Diagrams, 9 Graphs.
Autor:
Doweyko, Arthur1 arthur.doweyko@bms.com
Publikováno v:
Journal of Computer-Aided Molecular Design. Jul2004, Vol. 18 Issue 7-9, p587-596. 10p.