Surrogate endpoints for overall survival in locally advanced head and neck cancer: meta-analyses of individual patient data

Autor: Michiels, Stefan, Le Maître, Aurélie, Buyse, Marc, Burzykowski, Tomasz, Maillard, Emilie, Bogaerts, Jan, Vermorken, Jan B, Budach, Wilfried, Pajak, Thomas F, Ang, Kian K, Bourhis, Jean, Pignon, Jean-Pierre, Bernier, J, Budach, V, Brizel, D, Chalkidou, S, Cohen, E, Calais, G, Dowbrowsky, W, Fallai, C, Giglio, R, Horiot, JC, Huguenin, P, Jaulerry, C, Monson, K, Olmi, P, Overgaard, Jens, Rufibach, K, Stuetzer, H, Wernecke, KD, Syz, N, Amand, C, Mekranter, B, Midavaine, M

Publikováno v: Michiels, S, Le Maître, A, Buyse, M, Burzykowski, T, Maillard, E, Bogaerts, J, Vermorken, J B, Budach, W, Pajak, T F, Ang, K K, Bourhis, J, Pignon, J-P, MARCH and MACH-NC Collaborative Groups, Bernier, J, Budach, V, Brizel, D, Chalkidou, S, Cohen, E, Calais, G, Dowbrowsky, W, Fallai, C, Giglio, R, Horiot, JC, Huguenin, P, Jaulerry, C, Monson, K, Olmi, P, Overgaard, J, Rufibach, K, Stuetzer, H, Wernecke, KD, Syz, N, Amand, C, Mekranter, B & Midavaine, M 2009, ' Surrogate endpoints for overall survival in locally advanced head and neck cancer: meta-analyses of individual patient data ', Lancet Oncology, vol. 10, no. 4, pp. 341-50 . https://doi.org/10.1016/S1470-2045(09)70023-3

Summary Background The gold standard endpoint in randomised trials of locally advanced head and neck squamous-cell carcinoma (HNSCC) is overall survival. Our objective was to study whether duration of locoregional control or event-free survival (EFS)

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https://pubmed.ncbi.nlm.nih.gov/19341966