Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Dovile Sinkeviciute"'
Autor:
Sofie Falkenløve Madsen, Dovile Sinkeviciute, Christian S. Thudium, Morten A. Karsdal, Anne-Christine Bay-Jensen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Type III collagen gene expression is upregulated in the synovium of patients with rheumatoid arthritis (RA) presenting the fibroid phenotype. The soluble type III collagen formation biomarker, PRO-C3, is known to measure fibrogenesis in fibr
Externí odkaz:
https://doaj.org/article/9dfeba6e89044064af703a8e285e3add
Autor:
Helena Port, Cecilie Møller Hausgaard, Yi He, Walter P. Maksymowych, Stephanie Wichuk, Dovile Sinkeviciute, Anne-Christine Bay-Jensen, Signe Holm Nielsen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Rheumatic joints have an altered cartilage turnover. Cartilage intermediate layer protein 1 (CILP-1) is secreted from articular chondrocytes and deposited into the cartilage extracellular matrix. We developed an immunoassay targeting a Matri
Externí odkaz:
https://doaj.org/article/af44c2e9fbf847fbb3d672cdaf50d3ad
Autor:
Mohammed Ghiboub, Matthew Bell, Dovile Sinkeviciute, Rab K. Prinjha, Menno P. J. de Winther, Nicola R. Harker, David F. Tough, Wouter J. de Jonge
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 5, Pp 4228-4245 (2023)
SP140 is an epigenetic reader protein expressed predominantly in immune cells. GWAS studies have shown an association between SP140 single nucleotide polymorphisms (SNPs) and diverse autoimmune and inflammatory diseases, suggesting a possible pathoge
Externí odkaz:
https://doaj.org/article/3c050099aea741a3bd355412024aa66a
Publikováno v:
BMC Rheumatology, Vol 4, Iss 1, Pp 1-15 (2020)
Abstract Background Osteoarthritis (OA) is a progressive, chronic disease characterized by articular cartilage destruction. The pro-inflammatory cytokine IL-17 levels have been reported elevated in serum and synovial fluid of OA patients and correlat
Externí odkaz:
https://doaj.org/article/b0d3a653c94b4a36b256999859e9bbe8
Autor:
Solveig Skovlund Groen, Dovile Sinkeviciute, Anne-Christine Bay-Jensen, Christian S. Thudium, Morten A. Karsdal, Simon Francis Thomsen, Sven Lindemann, Daniela Werkmann, Joseph Blair, Line Mærsk Staunstrup, Patrik Önnerfjord, Lars Arendt-Nielsen, Signe Holm Nielsen
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 3, Iss 4, Pp 100207- (2021)
Objectives: There is an unmet medical need for biomarkers in OA which can be applied in clinical drug development trials. The present study describes the development of a specific and robust assay measuring type II collagen degradation (T2CM) and dis
Externí odkaz:
https://doaj.org/article/dbead7b88abd48ba819c5601d42f0785
Autor:
Yunyun Luo, Dovile Sinkeviciute, Yi He, Morten Karsdal, Yves Henrotin, Ali Mobasheri, Patrik Önnerfjord, Anne Bay-Jensen
Publikováno v:
Protein & Cell, Vol 8, Iss 8, Pp 560-572 (2017)
ABSTRACT Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attent
Externí odkaz:
https://doaj.org/article/d79cea50b7324ecc85ba2e55afed252a
Autor:
Patryk J. Drobinski, Neel I. Nissen, Dovile Sinkeviciute, Nicholas Willumsen, Morten A. Karsdal, Anne C. Bay-Jensen
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 321
Drobinski, P J, Nissen, N I, Sinkeviciute, D, Willumsen, N, Karsdal, M A & Bay-Jensen, A C 2023, ' In Contrast to Anti-CCP, MMP-Degraded and Citrullinated Vimentin (VICM) Is Both a Diagnostic and a Treatment Response Biomarker ', International Journal of Molecular Sciences, vol. 24, no. 1, 321 . https://doi.org/10.3390/ijms24010321
Drobinski, P J, Nissen, N I, Sinkeviciute, D, Willumsen, N, Karsdal, M A & Bay-Jensen, A C 2023, ' In Contrast to Anti-CCP, MMP-Degraded and Citrullinated Vimentin (VICM) Is Both a Diagnostic and a Treatment Response Biomarker ', International Journal of Molecular Sciences, vol. 24, no. 1, 321 . https://doi.org/10.3390/ijms24010321
Protein citrullination and degradation by matrix metalloproteinases (MMP) plays a central role in the pathology of rheumatoid arthritis (RA). Autoantibodies are known to target citrullinated vimentin. The aim of this study was to investigate the rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394c4bc2a1136a67e0186bd7db552727
https://pubmed.ncbi.nlm.nih.gov/36613765
https://pubmed.ncbi.nlm.nih.gov/36613765
Autor:
Anne-Christine Bay-Jensen, Shu Sun, Dovile Sinkeviciute, Patrik Önnerfjord, Salome Kristensen, Signe Holm Nielsen, Solveig Skovlund Groen, Anders Aspberg, Tina Manon-Jensen
Publikováno v:
Sinkeviciute, D, Skovlund Groen, S, Sun, S, Manon-Jensen, T, Aspberg, A, Önnerfjord, P, Bay-Jensen, A C, Kristensen, S & Nielsen, S H 2020, ' A novel biomarker of MMP-cleaved prolargin is elevated in patients with psoriatic arthritis ', Scientific Reports, vol. 10, no. 1, 13541 . https://doi.org/10.1038/s41598-020-70327-0
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Sinkeviciute, D, Skovlund Groen, S, Sun, S, Manon-Jensen, T, Aspberg, A, Önnerfjord, P, Bay-Jensen, A-C, Kristensen, S & Holm Nielsen, S 2020, ' A novel biomarker of MMP-cleaved prolargin is elevated in patients with psoriatic arthritis ', Scientific Reports, vol. 10, no. 1, 13541 . https://doi.org/10.1038/s41598-020-70327-0
Sinkeviciute, D, Groen, S S, Sun, S, Manon-Jensen, T, Aspberg, A, Onnerfjord, P, Bay-Jensen, A-C, Kristensen, S & Nielsen, S H 2020, ' A novel biomarker of MMP-cleaved prolargin is elevated in patients with psoriatic arthritis ', Scientific Reports, vol. 10, no. 1, 13541 . https://doi.org/10.1038/s41598-020-70327-0
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Sinkeviciute, D, Skovlund Groen, S, Sun, S, Manon-Jensen, T, Aspberg, A, Önnerfjord, P, Bay-Jensen, A-C, Kristensen, S & Holm Nielsen, S 2020, ' A novel biomarker of MMP-cleaved prolargin is elevated in patients with psoriatic arthritis ', Scientific Reports, vol. 10, no. 1, 13541 . https://doi.org/10.1038/s41598-020-70327-0
Sinkeviciute, D, Groen, S S, Sun, S, Manon-Jensen, T, Aspberg, A, Onnerfjord, P, Bay-Jensen, A-C, Kristensen, S & Nielsen, S H 2020, ' A novel biomarker of MMP-cleaved prolargin is elevated in patients with psoriatic arthritis ', Scientific Reports, vol. 10, no. 1, 13541 . https://doi.org/10.1038/s41598-020-70327-0
Psoriatic arthritis (PsA) is a chronic musculoskeletal inflammatory disease found in up to 30% of psoriasis patients. Prolargin—an extracellular matrix (ECM) protein present in cartilage and tendon—has been previously shown elevated in serum of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51495302d806dd84d1303612fe33fa80
https://doi.org/10.1038/s41598-020-70327-0
https://doi.org/10.1038/s41598-020-70327-0
Additional file 1: Figure S1. Dose-response test of bovine articular cartilage explants (BEX) by assessing MMP-mediated type II collagen degradation on day 14 of bovine explant culture. Data from 1 cow, 6 individually cultured explants per each treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232491bfd86152e6817739644d9d4411
Autor:
Anne-Christine Bay-Jensen, Sven Lindemann, Signe Holm Nielsen, Solveig Skovlund Groen, Dovile Sinkeviciute, Patrik Önnerfjord, Christian S. Thudium, Simon Francis Thomsen, Lars Arendt-Nielsen, Morten A. Karsdal, Line Mærsk Staunstrup, Joseph P.M. Blair, Daniela Werkmann
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 3, Iss 4, Pp 100207-(2021)
Objectives: There is an unmet medical need for biomarkers in OA which can be applied in clinical drug development trials. The present study describes the development of a specific and robust assay measuring type II collagen degradation (T2CM) and dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265b46754d54c5afe51b1a1fead6ee6f
https://doi.org/10.1016/j.ocarto.2021.100207
https://doi.org/10.1016/j.ocarto.2021.100207