Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Dove, Jeffrey H."'
Autor:
Aurélie Winterhalter, Sharadha Subramanian, Tiffany Tsang, Jean-Michel Florent, Stephen F. Hardy, Laura Tandeske, Armin Widmer, Arndt Meyer, Johanna M. Jansen, Charles Wartchow, S. Rieffel, Stephania Widger, Yumin Dai, Tatiana Zavorotinskaya, Savithri Ramurthy, Dove Jeffrey H, Yun Feng, Julia Klopp, Isabel Zaror, Kenneth Crawford, Alvar D. Gossert, Susan Fong, Darrin Stuart, Yuji Mishina, John Fuller, Gwynn Pardee, Andreas Lingel, Lenahan William P, Keith B. Pfister, Mohammad Hekmat-Nejad, Jamie Narberes, Eric Fang, Dirksen E. Bussiere, Sylvia Ma, Wolfgang Jahnke, Jan Marie Cheng, Chrystèle Henry
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174706 (2017)
PLoS ONE, 12 (4)
PLoS ONE
PLoS ONE, 12 (4)
PLoS ONE
RAS mutations lead to a constitutively active oncogenic protein that signals through multiple effector pathways. In this chemical biology study, we describe a novel coupled biochemical assay that measures activation of the effector BRAF by prenylated
Autor:
Pick Teresa E, Darrin Stuart, Poon Daniel J, Johanna M. Jansen, Barry Levine, Mina Aikawa, Susan Fong, Jonah Michaelian, Leonard Sung, Christopher McBride, Cynthia M. Shafer, Savithri Ramurthy, Paul A. Renhowe, Sandhya Girish, Sylvia Ma, Dove Jeffrey H, Sharadha Subramanian, Abran Costales, Payman Amiri
Publikováno v:
Journal of Medicinal Chemistry. 51:7049-7052
A series of arylaminobenzimidazoles was designed and synthesized as Raf kinase inhibitors. Exploration of the structure-activity relationship resulted in compounds that are potent in vitro and show desirable in vivo properties.
Autor:
Alvar D. Gossert, Dove Jeffrey H, Sharadha Subramanian, Susan Fong, Bill Lenahan, Gwynn Pardee, Simona Gokhin, Andreas Lingel, Arndt Meyer, Savithri Ramurthy, Laura Tandeske, David Farley, Charles Wartchow, Tatiana Zavorotinskaya, Julia Klopp, John Fuller, Kevin Shoemaker, Eric Fang, Anke Blechschmidt, Yumin Dai, Chrystèle Henry, Isabel Zaror, Dirksen E. Bussiere, Wolfgang Jahnke, Jean-Michel Florent, C. Gregory Paris, Keith B. Pfister, Mohammad Hekmat-Nejad, Jamie Narberes, Johanna M. Jansen, Stephen F. Hardy, Armin Widmer, Stephania Widger, Tiffany Tsang, Paul A. Renhowe, S. Rieffel
Publikováno v:
Molecular Cancer Research. 12:B38-B38
Mutated forms of KRAS are no longer able to switch effectors between “on” and “off” states. It is known that the function of KRAS is controlled by key parts in the C-terminus, including six consecutive lysines, a terminal prenyl moiety and a
Publikováno v:
European journal of immunology. 22(12)
For optimal activation of T cells, binding of their T cell receptor to antigenic peptides in the context of major histocompatibility complex molecules on antigen-presenting cells (APC) is not sufficient. Accessory signals, provided by accessory cells
Autor:
Mhashilkar, Abner M., Lavecchio, Joyce, Eberhardt, Bridget, Porter-Brooks, Julie, Boisot, Saskia, Dove, Jeffrey H., Pumphrey, Carla, Li, Xuguang, Weissmahr, Richard N., Ring, David B., Ramstedt, Urban, Marasco, Wayne A.
Publikováno v:
Human Gene Therapy; June 10, 1999, Vol. 10 Issue: 9 p1453-1467, 15p