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Proinflammatory cytokines promote glial heme oxygenase-1 expression and mitochondrial iron deposition: implications for multiple sclerosis

Autor: Yogesh Mawal, J. Corcos, Demetrios J. Sahlas, Hyman M. Schipper, S. Dion, Dov Frankel, Khalil Mehindate, Adrienne Liberman

Publikováno v: Journal of Neurochemistry. 77:1386-1395

Proinflammatory cytokines, pathological iron deposition, and oxidative stress have been implicated in the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). HO-1 mRNA levels and mitochondrial uptake of [(55)F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0868fe1049a2065c2dc07a3169a7e5cf
https://doi.org/10.1046/j.1471-4159.2001.00354.x

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Autor: Leonard Pinsky, Dov Frankel, Valerie Panet-Raymond, Anna Bibikova, Mark Trifiro, Adrian Sculptoreanu, Abdullah A. R. Abdullah, Hanan Abramovici, Hyman M. Schipper

Publikováno v: Molecular and Cellular Biochemistry. 203:23-31

We have analyzed Ca2+ currents in two neuroblastoma-motor neuron hybrid cell lines that expressed normal or glutamine-expanded human androgen receptors (polyGln-expanded AR) either transiently or stably. The cell lines express a unique, low-threshold

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f99e0b1020cd676820b3ec0d910a77d7
https://doi.org/10.1023/a:1007010020228

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Role of heme oxygenase-1 in the regulation of manganese superoxide dismutase gene expression in oxidatively-challenged astroglia

Autor: Khalil Mehindate, Hyman M. Schipper, Dov Frankel

Publikováno v: Journal of Cellular Physiology. 185:80-86

Manganese superoxide dismutase (MnSOD) is an antioxidant enzyme that reduces superoxide anion to hydrogen peroxide in cell mitochondria. MnSOD is overexpressed in normal aging brain and in various central nervous system disorders; however, the mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::954c18e009b27738f181fe2ee81715ce
https://doi.org/10.1002/1097-4652(200010)185:1<80::aid-jcp7>3.0.co

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Spinobulbar muscular atrophy: polyglutamine-expanded androgen receptor is proteolytically resistant in vitro and processed abnormally in transfected cells

Autor: Leonard Pinsky, Carlos Alvarado, Valerie Panet-Raymond, Hyman M. Schipper, Dov Frankel, Mark Trifiro, Abdullah A. R. Abdullah, Sunita de Tourreil

Publikováno v: Human molecular genetics. 7(3)

The neuronotoxicity of genes with expanded CAG repeats is most likely mediated by their respective polyglutamine (Gln)-expanded gene products. Gln- expanded portions of these products may be sufficient, or necessary, for pathogenesis. We tested wheth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c08e504939d9606f5da3236e0a20ab3
https://pubmed.ncbi.nlm.nih.gov/9466993

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