Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Dov B. Ballak"'
Autor:
Vienna E. Brunt, Akpevweoghene P. Ikoba, Brian P. Ziemba, Dov B. Ballak, Alexander Hoischen, Charles A. Dinarello, Marissa A. Ehringer, Douglas R. Seals
Publikováno v:
GeroScience, 45, 65-84
GeroScience, 45, 1, pp. 65-84
GeroScience, 45, 1, pp. 65-84
Item does not contain fulltext Aging is characterized by declines in physiological function that increase risk of age-associated diseases and limit healthspan, mediated in part by chronic low-grade inflammation. Interleukin (IL)-37 suppresses inflamm
Autor:
Erik J M Toonen, Andreea-Manuela Mirea, Cees J Tack, Rinke Stienstra, Dov B Ballak, Janna A van Diepen, Anneke Hijmans, Triantafyllos Chavakis, Wim H Dokter, Christine T N Pham, Mihai G Netea, Charles A Dinarello, Leo A B Joosten
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 202-214 (2016)
Abstract Activation of inflammatory pathways is known to accompany development of obesity-induced nonalcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes. In addition to caspase-1, the neutrophil serine proteases proteinase 3
Externí odkaz:
https://doaj.org/article/9fd3b3e028b347669261286dd8c2a8d2
Autor:
Eline N. Kuipers, Andrea D. van Dam, Dov B. Ballak, Ellemiek A. de Wit, Charles A. Dinarello, Rinke Stienstra, Janna A. van Diepen, Patrick C.N. Rensen, Mariëtte R. Boon
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2264 (2018)
The human cytokine interleukin (IL)-37 is an anti-inflammatory member of the IL-1 family of cytokines. Transgenic expression of IL-37 in mice protects them from diet-induced obesity and associated metabolic complications including dyslipidemia, infla
Externí odkaz:
https://doaj.org/article/4dbb2c7596974308ac867267ee07ce91
Autor:
Dov B Ballak, Edwin J P van Asseldonk, Janna A van Diepen, Henry Jansen, Anneke Hijmans, Leo A B Joosten, Cees J Tack, Mihai G Netea, Rinke Stienstra
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123152 (2015)
Innate immunity plays a pivotal role in obesity-induced low-grade inflammation originating from adipose tissue. Key receptors of the innate immune system including Toll-like receptors-2 and -4 (TLRs) are triggered by nutrient excess to promote inflam
Externí odkaz:
https://doaj.org/article/52f4d0cf8cf4427d97bb59e49814a078
Autor:
Dov B Ballak, Peter van Essen, Janna A van Diepen, Henry Jansen, Anneke Hijmans, Tetsuya Matsuguchi, Helmut Sparrer, Cees J Tack, Mihai G Netea, Leo A B Joosten, Rinke Stienstra
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89615 (2014)
Chronic low-grade inflammation in adipose tissue often accompanies obesity, leading to insulin resistance and increasing the risk for metabolic diseases. MAP3K8 (TPL2/COT) is an important signal transductor and activator of pro-inflammatory pathways
Externí odkaz:
https://doaj.org/article/48bc0581a7f04000bf62747d8c6338f4
Autor:
Erik J M Toonen, Anke J Laskewitz, Theo H van Dijk, Aycha Bleeker, Aldo Grefhorst, Annelies E Schouten, Ellen A J Bastiaanssen, Dov B Ballak, Marije I Koenders, Cindy van Doorn, Monique A J van der Vleuten, Marie-Jose C van Lierop, Albert K Groen, Wim H A Dokter
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e98684 (2014)
Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory drugs, but chronic use is hampered by metabolic side effects. Therefore, there is an urgent medical need for improved GCs that are as effective as classical GCs but have a bett
Externí odkaz:
https://doaj.org/article/6ad073e9b532425b9c32ea1bda826964
Autor:
Ganesh R. Talekar, Jamie Y. Story, James DeGregori, Raira S. Ank, Christopher C. Porter, Miyoung Lee, Curtis J. Henry, Jamie A.G. Hamilton, Andrew Fedanov, Talia Sisroe, Charles A. Dinarello, Dov B. Ballak, Rae Hunter, Sunil S. Raikar, Elan Z. Eisenmesser
Publikováno v:
Aging Cell
Aging‐associated declines in innate and adaptive immune responses are well documented and pose a risk for the growing aging population, which is predicted to comprise greater than 40 percent of the world's population by 2050. Efforts have been made
Autor:
Douglas R. Seals, Leo A. B. Joosten, Calin D. Popa, Dov B. Ballak, Edward D. Chan, Zackary Sapinsley, Michelle S M A Damen, Xiyuan Bai
Publikováno v:
Cytokine, 125
Low-grade inflammation is associated with the development of insulin resistance in obese individuals. The present study aims to provide additional evidence strengthening the role of interleukin (IL)-32 in this key process. Using an IL-32 transgenic (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab1f08c3f80ff968483afa760f1d563
http://hdl.handle.net/2066/214089
http://hdl.handle.net/2066/214089
Autor:
Brian P. Ziemba, Lawrence C. Johnson, Melanie C. Zigler, James J Richey, Rachel Culp-Hill, Rachel A. Gioscia-Ryan, Angelo D'Alessandro, Elan Z. Eisenmesser, Douglas R. Seals, Charles A. Dinarello, Zachary J Sapinsley, Dov B. Ballak, Vienna E. Brunt
Publikováno v:
Aging Cell
Aging is associated with vascular endothelial dysfunction, reduced exercise tolerance, and impaired whole‐body glucose metabolism. Interleukin‐37 (IL‐37), an anti‐inflammatory cytokine of the interleukin‐1 family, exerts salutary physiologi
Autor:
Suzhao Li, Rinke Stienstra, Jonathan Lucien Stahl, Tania Azam, Cees J. Tack, Douglas R. Seals, Isak W. Tengesdal, Benjamin J Swartzwelter, Giulio Cavalli, Janna A. van Diepen, Charles A. Dinarello, Thomas Mandrup-Poulsen, Viola Klück, Dov B. Ballak
Publikováno v:
Journal of Biological Chemistry, 293, 14224-14236
Journal of Biological Chemistry 293 (2018) 37
Journal of Biological Chemistry, 293, 37, pp. 14224-14236
Journal of Biological Chemistry, 293(37), 14224-14236
Journal of Biological Chemistry 293 (2018) 37
Journal of Biological Chemistry, 293, 37, pp. 14224-14236
Journal of Biological Chemistry, 293(37), 14224-14236
Obesity and the metabolic syndrome are characterized by chronic, low-grade inflammation mainly originating from expanding adipose tissue and resulting in inhibition of insulin signaling and disruption of glycemic control. Transgenic mice expressing h