Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dov B, Shamir"'
Autor:
Erin E. Congdon, Jessica E. Chukwu, Dov B. Shamir, Jingjing Deng, Devyani Ujla, Hameetha B.R. Sait, Thomas A. Neubert, Xiang-Peng Kong, Einar M. Sigurdsson
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 157-173 (2019)
Background: Bringing antibodies from pre-clinical studies to human trials requires humanization, but this process may alter properties that are crucial for efficacy. Since pathological tau protein is primarily intraneuronal in Alzheimer's disease, th
Externí odkaz:
https://doaj.org/article/be5e77a5ea40444d949da97a0e989c9e
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
We and others have shown in various in vivo, ex vivo and cell culture models that several tau antibodies interact with pathological tau within neurons. To further clarify this interaction in a dynamic human model, we differentiated SH-SY5Y cells with
Externí odkaz:
https://doaj.org/article/0f74233ab16b469c9209c49f60069447
Autor:
Jessica E. Chukwu, Hameetha B.R. Sait, Einar M. Sigurdsson, Xiang-Peng Kong, Erin E. Congdon, Jingjing Deng, Dov B. Shamir, Thomas A. Neubert, Devyani Ujla
Publikováno v:
EBioMedicine. 42
Background Bringing antibodies from pre-clinical studies to human trials requires humanization, but this process may alter properties that are crucial for efficacy. Since pathological tau protein is primarily intraneuronal in Alzheimer's disease, the
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1779
Several tau antibody therapies are now in clinical trials and numerous other tau antibodies are in various stages of preclinical development to treat Alzheimer's disease and related tauopathies. This involves long-term studies in mouse models that ar
Publikováno v:
Methods in Molecular Biology ISBN: 9781493978151
Several tau antibody therapies are now in clinical trials and numerous other tau antibodies are in various stages of preclinical development to treat Alzheimer's disease and related tauopathies. This involves long-term studies in mouse models that ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e6ac98c991c16df86b771c4610cb243
https://doi.org/10.1007/978-1-4939-7816-8_22
https://doi.org/10.1007/978-1-4939-7816-8_22
Autor:
Veronica Gonzalez, Hameetha B. Rajamohamedsait, Charles A. Hoeffer, Suhail Rasool, Yan Lin, Wajitha J. Rajamohamedsait, Dov B. Shamir, Einar M. Sigurdsson, Josien Levenga, Erin E. Congdon, Senthilkumar Krishnaswamy, Jiaping Gu
Publikováno v:
Molecular Neurodegeneration
Background A few tau immunotherapies are now in clinical trials with several more likely to be initiated in the near future. A priori, it can be anticipated that an antibody which broadly recognizes various pathological tau aggregates with high affin
Autor:
Suhail Rasool, Nina Helen Rosenqvist, Einar M. Sigurdsson, Dov B. Shamir, Jan Torleif Pedersen
Publikováno v:
Alzheimer'sdementia : the journal of the Alzheimer's Association. 12(10)
Introduction Tau immunotherapy has emerged as a promising approach to clear tau aggregates from the brain. Our previous findings suggest that tau antibodies may act outside and within neurons to promote such clearance. Methods We have developed an ap
Autor:
Einar M. Sigurdsson, Jan Torleif Pedersen, Suhail Rasool, Dov B. Shamir, Nina Helen Rosenqvist
Publikováno v:
Alzheimer's & Dementia. 10