Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Douwe M. Veltman"'
Autor:
Xuehua Xu, Henderikus Pots, Bernd K. Gilsbach, Dustin Parsons, Douwe M. Veltman, Sharmila G. Ramachandra, Haoran Li, Arjan Kortholt, Tian Jin
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Phagocytosis, macropinocytosis, and G protein coupled receptor-mediated chemotaxis are Ras-regulated and actin-driven processes. The common regulator for Ras activity in these three processes remains unknown. Here, we show that C2GAP2, a Ras GTPase a
Externí odkaz:
https://doaj.org/article/63ae01881cbf47c6a1fbbc45891e3fbe
Autor:
Peggy Paschke, David A Knecht, Augustinas Silale, David Traynor, Thomas D Williams, Peter A Thomason, Robert H Insall, Jonathan R Chubb, Robert R Kay, Douwe M Veltman
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196809 (2018)
Dictyostelium has a mature technology for molecular-genetic manipulation based around transfection using several different selectable markers, marker re-cycling, homologous recombination and insertional mutagenesis, all supported by a well-annotated
Externí odkaz:
https://doaj.org/article/e50838345c6640ac94a37f459c8aab21
Autor:
Douwe M. Veltman, Claudia Ortiz-Mateos, Henderikus Pots, Ineke Keizer-Gunnink, Wouter N. van Egmond, Arjan Kortholt, Peter J.M. van Haastert
Publikováno v:
Molecular Biology of the Cell, 32(20):mbcE21040171, 1-14. AMER SOC CELL BIOLOGY
Molecular Biology of the Cell
Molecular Biology of the Cell
In Dictyostelium, chemoattractants induce a fast cGMP response that mediates myosin filament formation in the rear of the cell. The major cGMP signaling pathway consists of a soluble guanylyl cyclase sGC, a cGMP-stimulated cGMP-specific phosphodieste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f5956b7b642bc742774cc12f2507fb
https://hdl.handle.net/11370/d5ab0de6-3ca4-4e38-9c10-d21e785620c7
https://hdl.handle.net/11370/d5ab0de6-3ca4-4e38-9c10-d21e785620c7
Autor:
Douwe M Veltman, Thomas D Williams, Gareth Bloomfield, Bi-Chang Chen, Eric Betzig, Robert H Insall, Robert R Kay
Publikováno v:
eLife, Vol 5 (2016)
Macropinocytosis is a fundamental mechanism that allows cells to take up extracellular liquid into large vesicles. It critically depends on the formation of a ring of protrusive actin beneath the plasma membrane, which develops into the macropinocyti
Externí odkaz:
https://doaj.org/article/65db319e912842dca494acd238a2fdf7
Autor:
Gareth Bloomfield, David Traynor, Sophia P Sander, Douwe M Veltman, Justin A Pachebat, Robert R Kay
Publikováno v:
eLife, Vol 4 (2015)
Cells use phagocytosis and macropinocytosis to internalise bulk material, which in phagotrophic organisms supplies the nutrients necessary for growth. Wildtype Dictyostelium amoebae feed on bacteria, but for decades laboratory work has relied on axen
Externí odkaz:
https://doaj.org/article/058fdb0aa1d442d0ba8ebb5bfce96679
Autor:
Arjan Kortholt, Henderikus Pots, Tian Jin, Douwe M. Veltman, Xuehua Xu, Xi Wen, Ineke Keizer-Gunnink
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 114(47), 10092-10101. NATL ACAD SCIENCES
Eukaryotic cells chemotax in a wide range of chemoattractant concentration gradients, and thus need inhibitory processes that terminate cell responses to reach adaptation while maintaining sensitivity to higher-concentration stimuli. However, the mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6517e1ac1b238e8b87d45218a3995c1
https://doi.org/10.1073/pnas.1703208114
https://doi.org/10.1073/pnas.1703208114
Autor:
Peggy, Paschke, David A, Knecht, Thomas D, Williams, Peter A, Thomason, Robert H, Insall, Jonathan R, Chubb, Robert R, Kay, Douwe M, Veltman
Publikováno v:
Journal of Visualized Experiments : JoVE
Dictyostelium discoideum is an intriguing model organism for the study of cell differentiation processes during development, cell signaling, and other important cellular biology questions. The technologies available to genetically manipulate Dictyost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ed8f407d9ed3ea2a2e165d4029dc47b
https://pubmed.ncbi.nlm.nih.gov/30735174
https://pubmed.ncbi.nlm.nih.gov/30735174
Autor:
Peter A. Thomason, David A. Knecht, Douwe M. Veltman, Thomas D. Williams, Robert R. Kay, Robert H. Insall, Peggy Paschke, Jonathan R. Chubb
Publikováno v:
Journal of Visualized Experiments.
Dictyostelium discoideum is an intriguing model organism for the study of cell differentiation processes during development, cell signaling, and other important cellular biology questions. The technologies available to genetically manipulate Dictyost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5144090391bb2c67df43c20f0b5430f1
https://doi.org/10.3791/58981
https://doi.org/10.3791/58981
Publikováno v:
Current Opinion in Cell Biology. 36:7-12
Model organisms have been key to understanding many core biological processes. Dictyostelium amoebae have the attributes required to perform this role for chemotaxis, and by providing an evolutionary distant reference point to mammalian cells, they a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973a8045143409f70421ed1f669709ce
https://doi.org/10.1016/j.ceb.2015.06.005
https://doi.org/10.1016/j.ceb.2015.06.005
Autor:
Douwe M. Veltman
Publikováno v:
Biochemical Society Transactions. 43:129-132
The cytoskeleton is utilized for a variety of cellular processes, including migration, endocytosis and adhesion. The required molecular components are often shared between different processes, but it is not well understood how the cells balance their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b4013e213aab1869dec97fc53c25c8
https://doi.org/10.1042/bst20140251
https://doi.org/10.1042/bst20140251