Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Douwe M. Veltman"'
Autor:
Xuehua Xu, Henderikus Pots, Bernd K. Gilsbach, Dustin Parsons, Douwe M. Veltman, Sharmila G. Ramachandra, Haoran Li, Arjan Kortholt, Tian Jin
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Phagocytosis, macropinocytosis, and G protein coupled receptor-mediated chemotaxis are Ras-regulated and actin-driven processes. The common regulator for Ras activity in these three processes remains unknown. Here, we show that C2GAP2, a Ras GTPase a
Externí odkaz:
https://doaj.org/article/63ae01881cbf47c6a1fbbc45891e3fbe
Autor:
Peggy Paschke, David A Knecht, Augustinas Silale, David Traynor, Thomas D Williams, Peter A Thomason, Robert H Insall, Jonathan R Chubb, Robert R Kay, Douwe M Veltman
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196809 (2018)
Dictyostelium has a mature technology for molecular-genetic manipulation based around transfection using several different selectable markers, marker re-cycling, homologous recombination and insertional mutagenesis, all supported by a well-annotated
Externí odkaz:
https://doaj.org/article/e50838345c6640ac94a37f459c8aab21
Autor:
Douwe M. Veltman, Claudia Ortiz-Mateos, Henderikus Pots, Ineke Keizer-Gunnink, Wouter N. van Egmond, Arjan Kortholt, Peter J.M. van Haastert
Publikováno v:
Molecular Biology of the Cell, 32(20):mbcE21040171, 1-14. AMER SOC CELL BIOLOGY
Molecular Biology of the Cell
Molecular Biology of the Cell
In Dictyostelium, chemoattractants induce a fast cGMP response that mediates myosin filament formation in the rear of the cell. The major cGMP signaling pathway consists of a soluble guanylyl cyclase sGC, a cGMP-stimulated cGMP-specific phosphodieste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f5956b7b642bc742774cc12f2507fb
https://hdl.handle.net/11370/d5ab0de6-3ca4-4e38-9c10-d21e785620c7
https://hdl.handle.net/11370/d5ab0de6-3ca4-4e38-9c10-d21e785620c7
Autor:
Douwe M Veltman, Thomas D Williams, Gareth Bloomfield, Bi-Chang Chen, Eric Betzig, Robert H Insall, Robert R Kay
Publikováno v:
eLife, Vol 5 (2016)
Macropinocytosis is a fundamental mechanism that allows cells to take up extracellular liquid into large vesicles. It critically depends on the formation of a ring of protrusive actin beneath the plasma membrane, which develops into the macropinocyti
Externí odkaz:
https://doaj.org/article/65db319e912842dca494acd238a2fdf7
Autor:
Gareth Bloomfield, David Traynor, Sophia P Sander, Douwe M Veltman, Justin A Pachebat, Robert R Kay
Publikováno v:
eLife, Vol 4 (2015)
Cells use phagocytosis and macropinocytosis to internalise bulk material, which in phagotrophic organisms supplies the nutrients necessary for growth. Wildtype Dictyostelium amoebae feed on bacteria, but for decades laboratory work has relied on axen
Externí odkaz:
https://doaj.org/article/058fdb0aa1d442d0ba8ebb5bfce96679
Autor:
Andrew J Muinonen-Martin, Olivia Susanto, Qifeng Zhang, Elizabeth Smethurst, William J Faller, Douwe M Veltman, Gabriela Kalna, Colin Lindsay, Dorothy C Bennett, Owen J Sansom, Robert Herd, Robert Jones, Laura M Machesky, Michael J O Wakelam, David A Knecht, Robert H Insall
Publikováno v:
PLoS Biology, Vol 12, Iss 10, p e1001966 (2014)
The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs unusually early in tumour evolution. Unlike most solid tumours, thickness rather than cytological markers or differentiation is the best guide to metastatic potent
Externí odkaz:
https://doaj.org/article/d3993f4afdf3405ab98357b4e65f0fe6
Autor:
Matthew P Neilson, Douwe M Veltman, Peter J M van Haastert, Steven D Webb, John A Mackenzie, Robert H Insall
Publikováno v:
PLoS Biology, Vol 9, Iss 5, p e1000618 (2011)
The mechanism of eukaryotic chemotaxis remains unclear despite intensive study. The most frequently described mechanism acts through attractants causing actin polymerization, in turn leading to pseudopod formation and cell movement. We recently propo
Externí odkaz:
https://doaj.org/article/7a1b5840aecb4bf189ba8054dbaddbb7
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15309 (2010)
There has been a growing appreciation over the last decade that chemotaxis plays an important role in cancer migration, invasion and metastasis. Research into the field of cancer cell chemotaxis is still in its infancy and traditional investigative t
Externí odkaz:
https://doaj.org/article/5b69e78e26884e3192fda1b87699146f
Autor:
Arjan Kortholt, Henderikus Pots, Tian Jin, Douwe M. Veltman, Xuehua Xu, Xi Wen, Ineke Keizer-Gunnink
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 114(47), 10092-10101. NATL ACAD SCIENCES
Eukaryotic cells chemotax in a wide range of chemoattractant concentration gradients, and thus need inhibitory processes that terminate cell responses to reach adaptation while maintaining sensitivity to higher-concentration stimuli. However, the mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6517e1ac1b238e8b87d45218a3995c1
https://doi.org/10.1073/pnas.1703208114
https://doi.org/10.1073/pnas.1703208114
Autor:
Peggy, Paschke, David A, Knecht, Thomas D, Williams, Peter A, Thomason, Robert H, Insall, Jonathan R, Chubb, Robert R, Kay, Douwe M, Veltman
Publikováno v:
Journal of Visualized Experiments : JoVE
Dictyostelium discoideum is an intriguing model organism for the study of cell differentiation processes during development, cell signaling, and other important cellular biology questions. The technologies available to genetically manipulate Dictyost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ed8f407d9ed3ea2a2e165d4029dc47b
https://pubmed.ncbi.nlm.nih.gov/30735174
https://pubmed.ncbi.nlm.nih.gov/30735174