Severe pulmonary hypertension in chronic obstructive pulmonary disease – From clinical perspective to histological evidence

Autor: Katarina Zeder, Teresa Sassmann, Vasile Foris, Philipp Douschan, Horst Olschewski, Gabor Kovacs

Publikováno v: International Journal of Cardiology Congenital Heart Disease, Vol 17, Iss , Pp 100519- (2024)

Rationale: Severe pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) is currently defined by an elevated mean pulmonary arterial pressure and strongly elevated pulmonary vascular resistance >5 wood units. Clinically, these pa

Externí odkaz: https://doaj.org/article/86d84c02f6d14a54bbe3bbfdaac2b777

Longitudinal analysis of PD-L1 expression in patients with relapsed NSCLC

Autor: Florian Posch, Luka Brčić, Gudrun Absenger, Verena Schlintl, Nikolaus John, Robert Wurm, Philipp J Jost, Angelika Terbuch, Teresa Sassmann, Jörg Lindenmann, Melanie Fediuk, Philipp Douschan, Martin Zacharias, Lipika Kalson

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)

Background The use and approval of immune checkpoint inhibitors for the treatment of non-small cell lung cancer (NSCLC) depends on PD-L1 expression in the tumor tissue. Nevertheless, PD-L1 often fails to predict response to treatment. One possible ex

Externí odkaz: https://doaj.org/article/7b357905ef25400b8600961cad6d9dc2

The prognostic relevance of exercise pulmonary hypertension in cardiac and pulmonary diseases.

Autor: Zeder K; Division of Pulmonology, Department of Internal Medicine, Medical University of Graz.; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria.; Division of Cardiovascular Medicine, University of Maryland School of Medicine, Baltimore.; University of Maryland-Institute for Health Computing, Bethesda, Maryland, USA., Douschan P; Division of Pulmonology, Department of Internal Medicine, Medical University of Graz.; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria., Foris V; Division of Pulmonology, Department of Internal Medicine, Medical University of Graz.; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Sassmann T; Division of Pulmonology, Department of Internal Medicine, Medical University of Graz.; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria., Maron BA; Division of Cardiovascular Medicine, University of Maryland School of Medicine, Baltimore.; University of Maryland-Institute for Health Computing, Bethesda, Maryland, USA., Olschewski H; Division of Pulmonology, Department of Internal Medicine, Medical University of Graz.; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria., Kovacs G; Division of Pulmonology, Department of Internal Medicine, Medical University of Graz.; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria.

Publikováno v: Current opinion in pulmonary medicine [Curr Opin Pulm Med] 2024 Sep 01; Vol. 30 (5), pp. 451-458. Date of Electronic Publication: 2024 Jul 03.

Echocardiographic evaluation of right ventricular diastolic function in pulmonary hypertension

Autor: Athiththan Yogeswaran, Zvonimir A. Rako, Selin Yildiz, Hossein Ardeschir Ghofrani, Werner Seeger, Bruno Brito da Rocha, Henning Gall, Nils C. Kremer, Philipp Douschan, Silvia Papa, Carmine Dario Vizza, Domenico Filomena, Ryan J. Tedford, Robert Naeije, Manuel J. Richter, Roberto Badagliacca, Khodr Tello

Publikováno v: ERJ Open Research, Vol 9, Iss 5 (2023)

Background Right ventricular (RV) diastolic dysfunction may be prognostic in pulmonary hypertension (PH). However, its assessment is complex and relies on conductance catheterisation. We aimed to evaluate echocardiography-based parameters as surrogat

Externí odkaz: https://doaj.org/article/c85bc48591ed407c9f3a3d167f8b3a72

Apelin-17 to diagnose idiopathic pulmonary arterial hypertension: A biomarker study

Autor: Vasile Foris, Gabor Kovacs, Alexander Avian, Zoltán Bálint, Philipp Douschan, Bahil Ghanim, Walter Klepetko, Andrea Olschewski, Horst Olschewski

Publikováno v: Frontiers in Physiology, Vol 13 (2023)

Background: NT-proBNP and GDF-15 are established blood-derived biomarkers for risk assessment in pulmonary hypertension (PH), despite limited sensitivity and specificity. Apelin has a crucial function in endothelial homeostasis, thus it might represe

Externí odkaz: https://doaj.org/article/9b4ebb590a874cb0a61e6b956be28d58