Zobrazeno 1 - 10
of 775
pro vyhledávání: '"Douglas. A. Lauffenburger"'
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Metastatic breast cancer remains a largely incurable and fatal disease with liver involvement bearing the worst prognosis. The danger is compounded by a subset of disseminated tumor cells that may lie dormant for years to decades before re-emerging a
Externí odkaz:
https://doaj.org/article/f388283e67f24b669df2281c62c26233
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Single-cell omics technologies can measure millions of cells for up to thousands of biomolecular features, enabling data-driven studies of complex biological networks. However, these high-throughput experimental techniques often cannot track
Externí odkaz:
https://doaj.org/article/0c4e88dde96e4072afec81a8165dd451
Autor:
Nikolaos Meimetis, Krista M. Pullen, Daniel Y. Zhu, Avlant Nilsson, Trong Nghia Hoang, Sara Magliacane, Douglas A. Lauffenburger
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-19 (2024)
Abstract The development of therapeutics and vaccines for human diseases requires a systematic understanding of human biology. Although animal and in vitro culture models can elucidate some disease mechanisms, they typically fail to adequately recapi
Externí odkaz:
https://doaj.org/article/d709836e3f53497f9d22e8848afa7d5b
Autor:
Nadège Nziza, Yixiang Deng, Lianna Wood, Navneet Dhanoa, Naomi Dulit-Greenberg, Tina Chen, Abigail S. Kane, Zoe Swank, Jameson P. Davis, Melina Demokritou, Anagha P. Chitnis, Alessio Fasano, Andrea G. Edlow, Nitya Jain, Bruce H. Horwitz, Ryan P. McNamara, David R. Walt, Douglas A. Lauffenburger, Boris Julg, Wayne G. Shreffler, Galit Alter, Lael M. Yonker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Although young children generally experience mild symptoms following infection with SARS-CoV-2, severe acute and long-term complications can occur. SARS-CoV-2 mRNA vaccines elicit robust immunoglobulin profiles in children ages 5 years and o
Externí odkaz:
https://doaj.org/article/53fe3275b82d4cd68308952abe3b3f33
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109509- (2024)
Summary: Many diseases emerge from dysregulated cellular signaling, and drugs are often designed to target specific signaling proteins. Off-target effects are, however, common and may ultimately result in failed clinical trials. Here we develop a com
Externí odkaz:
https://doaj.org/article/e27deefd60e146d69deed574cc746216
Autor:
Kathryn A. Bowman, Christine D. Wiggins, Elizabeth DeRiso, Steffan Paul, Klemen Strle, John A. Branda, Allen C. Steere, Douglas A. Lauffenburger, Galit Alter
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108804- (2024)
Summary: Lyme arthritis, caused by the spirochete Borrelia burgdorferi, is the most common feature of late disseminated Lyme disease in the United States. While most Lyme arthritis resolves with antibiotics, termed “antibiotic-responsive”, some i
Externí odkaz:
https://doaj.org/article/f6db1607dbd8453285c5e1059d12f95e
Autor:
Sepideh Dolatshahi, Audrey L. Butler, Christian Pou, Ewa Henckel, Anna Karin Bernhardsson, Anna Gustafsson, Kajsa Bohlin, Sally A. Shin, Douglas A. Lauffenburger, Petter Brodin, Galit Alter
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Preterm newborns are more likely to suffer from infectious diseases at birth compared to children delivered at term. Whether this is due to compromised cellular, humoral, or organ-specific development remains unclear. To begin to define whet
Externí odkaz:
https://doaj.org/article/8fc58a6a919547fc9a5b74c10b44c35b
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Chemotherapy resistance is a major obstacle to curing cancer patients. Combination drug regimens have shown promise as a method to overcome resistance; however, to date only some cancers have been cured with this method. Collateral sensitivi
Externí odkaz:
https://doaj.org/article/85442402249043f691d06d36552a8d70
Autor:
Chuangqi Wang, Yijia Li, Paulina Kaplonek, Matteo Gentili, Stephanie Fischinger, Kathryn A. Bowman, Moshe Sade-Feldman, Kyle R. Kays, James Regan, James P. Flynn, Marcia B. Goldberg, Nir Hacohen, Michael R. Filbin, Douglas A. Lauffenburger, Galit Alter, Jonathan Z. Li
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Persistent SARS-CoV-2 replication and systemic dissemination are linked to increased COVID-19 disease severity and mortality. However, the precise immune profiles that track with enhanced viral clearance, particularly from systemic RNAemia,
Externí odkaz:
https://doaj.org/article/4fedcf9b53004f06aeb4f5c246c1eec3
Autor:
Yannic C. Bartsch, Stephanie Fischinger, Sameed M. Siddiqui, Zhilin Chen, Jingyou Yu, Makda Gebre, Caroline Atyeo, Matthew J. Gorman, Alex Lee Zhu, Jaewon Kang, John S. Burke, Matthew Slein, Matthew J. Gluck, Samuel Beger, Yiyuan Hu, Justin Rhee, Eric Petersen, Benjamin Mormann, Michael de St Aubin, Mohammad A. Hasdianda, Guruprasad Jambaulikar, Edward W. Boyer, Pardis C. Sabeti, Dan H. Barouch, Boris D. Julg, Elon R. Musk, Anil S. Menon, Douglas A. Lauffenburger, Eric J. Nilles, Galit Alter
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
The extent of antibody protection against SARS-CoV-2 remains unclear. Here, using a cohort of 120 seroconverted individuals, the authors longitudinally characterize neutralization, Fc-function, and SARS-CoV-2 specific T cell responses, which they sho
Externí odkaz:
https://doaj.org/article/c9653ceb7d9e4c3a8933d1abc7322637