Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Douglas W. Thomson"'
Autor:
Jean Garnier, Douglas W. Thomson, Shengze Zhou, Phillip I. Jolly, Leonard E. A. Berlouis, John A. Murphy
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 994-1002 (2012)
Neutral organic electron donors, featuring pyridinylidene–imidazolylidene, pyridinylidene–benzimidazolylidene and imidazolylidene–benzimidazolylidene linkages are reported. The pyridinylidene–benzimidazolylidene and imidazolylidene–benzimid
Externí odkaz:
https://doaj.org/article/8cf500d8e6e3461bb6327365887d926b
Autor:
Ana Kojic, Anna Rutkowska, Blandine S J McKay, Carsten Schultz, Douglas W. Thomson, Giovanna Bergamini, Marcel Mulbaier, Lee Edwards, Cécile Echalier
Publikováno v:
Chemical Communications. 57:1814-1817
Click chemistry probes have improved the study of drug interactions in live cells and relevant disease models. Proper design of the probes, including the choice of the click moiety coupled to the drug, is crucial to ensure good performance and broad
Autor:
Nils Kurzawa, Marcus Bantscheff, Mikhail M. Savitski, Eugenia Stonehouse, Maria Faelth-Savitski, Holger Franken, Bianca Heller, Christina Rau, Jessica Perrin, Anna Rutkowska, H. Christian Eberl, Johanna Vappiani, Daniel C. Sévin, Isabelle Becher, Katrin Strohmer, Jana Krause, Thilo Werner, Douglas W. Thomson, Wolfgang Huber, Daniel Poeckel, Giovanna Bergamini, Mathias Kalxdorf, Dorothee Childs
Publikováno v:
Nature Biotechnology. 38:303-308
Monitoring drug-target interactions with methods such as the cellular thermal-shift assay (CETSA) is well established for simple cell systems but remains challenging in vivo. Here we introduce tissue thermal proteome profiling (tissue-TPP), which mea
Autor:
Sebastien Andre Campos, Sorif Uddin, Daniel Thomas, Paul Rowland, Birgit Duempelfeld, Douglas W. Thomson, Andrew Sharpe, James E. Rowedder, Kenneth David Down, Máire A. Convery, Augustin Amour, Michael Daniel Goldsmith, Grant A. McGonagle, David N. Mallett, Edith M. Hessel, Jana Krause, Kevin James Doyle, J. Nicole Hamblin, Srividya Sriskantharajah, Edward P. Cannons, Vipulkumar Kantibhai Patel, Chris D. Edwards, Cole Clissold, Nick Barton, Anderson Niall Andrew, John J. Coward
Publikováno v:
Journal of medicinal chemistry. 64(18)
Optimization of a previously reported lead series of PI3Kδ inhibitors with a novel binding mode led to the identification of a clinical candidate compound 31 (GSK251). Removal of an embedded Ames-positive heteroaromatic amine by reversing a sulfonam
Autor:
Marcus Bantscheff, Daniel Poeckel, Ramanjulu Joshi M, Jessica Perrin, Christina Rau, Katrin Strohmer, Birgit Duempelfeld, Nico Zinn, G. Scott Pesiridis, Giovanna Bergamini, Marcel Muelbaier, Douglas W. Thomson, Anne J. Wagner, Viera Kasparcova, Alan P. Graves
Publikováno v:
ACS Med Chem Lett
[Image: see text] The serine/threonine protein kinase TBK1 (Tank-binding Kinase-1) is a noncanonical member of the IkB kinase (IKK) family. This kinase regulates signaling pathways in innate immunity, oncogenesis, energy homeostasis, autophagy, and n
Autor:
Giovanna Bergamini, Douglas W. Thomson
Publikováno v:
Expert opinion on therapeutic patents. 31(9)
Introduction: TANK-binding kinase 1 (TBK1) is a key mediator of innate immunity processes and studies have reported on its role in inflammatory and autoimmune diseases. Moreover, several studies ha...
Autor:
Cécile Echalier, Marcel Muelbaier, Giovanna Bergamini, Lee Edwards, Carsten Schultz, Blandine S J McKay, Anna Rutkowska, Douglas W. Thomson
Click probes have enabled a thorough study of drug interactions in relevant disease models. Proper design of the probes, including the choice of the click moiety coupled to the drug, is crucial to ensure good performance and broad application. A new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8018ecd869bc02d96f947decd0a91f
https://doi.org/10.26434/chemrxiv.13174286
https://doi.org/10.26434/chemrxiv.13174286
Autor:
Carsten Hopf, Anne J. Wagner, Daniel Poeckel, Christina Rau, Ray Edward Benson, Jana Krause, Gerard Drewes, John T. Moore, Elsa Salzer, John G. Emery, Douglas W. Thomson, Marcel Muelbaier, Lars Dittus, Katrin M. Mueller, Marcus Bantscheff, Birgit Duempelfeld, Lisa M. Shewchuk
Publikováno v:
Journal of Medicinal Chemistry. 60:5455-5471
The availability of high quality probes for specific protein targets is fundamental to the investigation of their function and their validation as therapeutic targets. We report the utilization of a dedicated chemoproteomic assay platform combining a
Autor:
Mui Cheung, Jennifer L. Ariazi, Shristy Tiwari, Sayan Mitra, Douglas W. Thomson, Giovanna Bergamini, Sanjay Kumar, Premkumar Arumugam, Vijaya G. Tirunagaru, Amit Awasthi, Venkatesh Babu Jayaraman, Mahesh Yanamandra, Tangirala Raghuram, Thilo Werner
Publikováno v:
Journal of Pharmaceutical Research International. 18:1-15
Background and Aim: Acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) is a key enzyme catalyzing the final step of triglyceride (TG) synthesis and is implicated in fat absorption and disposition. However, development of several DGAT1 inhibitors has
Autor:
Thilo Werner, Christina Rau, Marcus Bantscheff, David H. Drewry, Stephanie Lehmann, H. Christian Eberl, Peiling Chen, Gerard Drewes, Marcel Muelbaier, Friedrich B M Reinhard, Douglas W. Thomson, Cunyu Zhang
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Kinobeads are a set of promiscuous kinase inhibitors immobilized on sepharose beads for the comprehensive enrichment of endogenously expressed protein kinases from cell lines and tissues. These beads enable chemoproteomics profiling of kinase inhibit