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pro vyhledávání: '"Douglas W. Selinger"'
BackgroundThe outbreak of SARS CoV-2 has caused ever-increasing attention and public panic all over the world. Currently, there is no specific treatment against the SARS CoV-2. Therefore, identifying effective antiviral agents to combat the disease i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb15828bba6d8246814694e36a812500
https://doi.org/10.1101/2020.04.01.017624
https://doi.org/10.1101/2020.04.01.017624
Autor:
Ansgar Schuffenhauer, Thomas Nelson, Marie-Cecile Didiot, Frederick J. King, Douglas W. Selinger, Thibault Varin, Hua Wu, Claudia Agarinis, Christian N. Parker
Publikováno v:
ASSAY and Drug Development Technologies. 11:355-366
The use of small molecules to modulate cellular processes is a powerful approach to investigate gene function as a complement to genetic approaches. The discovery and characterization of compounds that modulate translation initiation, the rate-limiti
Autor:
Christian N. Parker, Chantale T. Guy, Ansgar Schuffenhauer, Reinhardt Juergen, Hanspeter Nick, Vic E. Myer, Douglas W. Selinger, Felix Freuler, Alan Buckler, Thibault Varin, Marie-Cecile Didiot, Jeffrey Hewett
Publikováno v:
SLAS Discovery. 18:407-419
Translation initiation is a fine-tuned process that plays a critical role in tumorigenesis. The use of small molecules that modulate mRNA translation provides tool compounds to explore the mechanism of translational initiation and to further validate
Autor:
Douglas W. Selinger, Savina Jaeger, Ben Cornett, Somnath Bandyopadhyay, Hua Wu, Florian Nigsch, Ioannis Moutsatsos, Janna Hutz, Gregory McAllister, Jeremy L. Jenkins, Thomas Nelson
Publikováno v:
SLAS Discovery. 18:367-377
Screens using high-throughput, information-rich technologies such as microarrays, high-content screening (HCS), and next-generation sequencing (NGS) have become increasingly widespread. Compared with single-readout assays, these methods produce a mor
Autor:
Peter ten Dijke, Chris Lu, Long Zhang, Andreas Bauer, Douglas W. Selinger, Xiaofei Zhang, Juan Zhang
Publikováno v:
The EMBO Journal. 32:996-1007
SMAD6 is a crucial feedback inhibitory regulator of bone morphogenetic protein (BMP)/SMAD signalling. Although little is known regarding the post-transcriptional modification of inhibitory SMADs and the mechanism by which their function is regulated.
Autor:
Daniel G. Sipes, Jeffrey A. Porter, Vic E. Myer, Jeff Janes, Douglas W. Selinger, Qing-Yin Wang, Pornwaratt Niyomrattanakitand, Timothy R. Smith, Frederick J. King, Achim Brinker, Felipa A. Mapa, Hua Wu
Publikováno v:
JALA: Journal of the Association for Laboratory Automation. 14:374-382
Cell-based, phenotypic screening of small molecules often identifies compounds with provocative biological properties. However, determining the cellular target(s) and/or mechanism of action (MoA) of lead compounds remains an extremely challenging and
Autor:
J. Demchak, P. Bouchard, T. Welker, Philippe Marc, R. Galicia, Florian Hahne, K. Therrien, K. Stango, B. Huang, Douglas W. Selinger, J. Walker, Arne Mueller
Publikováno v:
Toxicology Letters. 258:S121-S122
Publikováno v:
Trends in Biotechnology. 21:251-254
The nascent field of systems biology ambitiously proposes to integrate information from large-scale biology projects to create computational models that are, in some sense, complete. However, the details of what would constitute a complete systems-le
Autor:
John D. Benson, Esther K. Schmitt, Jonathan M Solomon, Hua Wu, Daniel Curtis, Kevin Lai, Douglas W. Selinger, Fabrizio C. Serluca
Publikováno v:
ACS chemical biology. 8(1)
Phenotypic compound screens can be used to identify novel targets in signaling pathways and disease processes, but the usefulness of these screens depends on the ability to quickly determine the target and mechanism of action of the molecules identif
Autor:
Daniel M. Janse, Douglas W. Selinger, George M. Church, Kevin J. Cheung, Vasudeo Badarinarayana
Publikováno v:
Genome research. 13(2)
Changes in DNA supercoiling are induced by a wide range of environmental stresses in Escherichia coli, but the physiological significance of these responses remains unclear. We now demonstrate that an increase in negative supercoiling is necessary fo