Combinatorial Loss of the Enzymatic Activities of Viral Uracil-DNA Glycosylase and Viral dUTPase Impairs Murine Gammaherpesvirus Pathogenesis and Leads to Increased Recombination-Based Deletion in the Viral Genome

Autor: Qiwen Dong, Kyle R. Smith, Darby G. Oldenburg, Maxwell Shapiro, William R. Schutt, Laraib Malik, Joshua B. Plummer, Yunxiang Mu, Thomas MacCarthy, Douglas W. White, Kevin M. McBride, Laurie T. Krug

Publikováno v: mBio, Vol 9, Iss 5 (2018)

ABSTRACT Misincorporation of uracil or spontaneous cytidine deamination is a common mutagenic insult to DNA. Herpesviruses encode a viral uracil-DNA glycosylase (vUNG) and a viral dUTPase (vDUT), each with enzymatic and nonenzymatic functions. Howeve

Externí odkaz: https://doaj.org/article/e0bb07380d1b4f38bdcc807e729ffc60

Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice.

Autor: Nick D Van Skike, Nana K Minkah, Chad H Hogan, Gary Wu, Peter T Benziger, Darby G Oldenburg, Mehmet Kara, Deborah M Kim-Holzapfel, Douglas W White, Scott A Tibbetts, Jarrod B French, Laurie T Krug

Publikováno v: PLoS Pathogens, Vol 14, Iss 2, p e1006843 (2018)

Gammaherpesviruses encode proteins with homology to the cellular purine metabolic enzyme formyl-glycinamide-phosphoribosyl-amidotransferase (FGARAT), but the role of these viral FGARATs (vFGARATs) in the pathogenesis of a natural host has not been in

Externí odkaz: https://doaj.org/article/b1341950bb304c61a8fd0dcb56a91ad8

Building an Astrophysics/Astrochemistry Laboratory from Scratch

Autor: Douglas W. White

Publikováno v: The Physics Teacher. 60:362-364

Laboratory astrophysics and astrochemistry are emerging fields highlighting the importance of laboratory simulations and experiments to benefit remote observations. In particular, ice mixtures found in the outer solar system may offer insight into th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7182a5215607ad6faa65343666f32e2e
https://doi.org/10.1119/10.0010394

Detection of antibodies to decorin-binding protein A (DbpA) and DbpB after infection of dogs with Borrelia burgdorferi by tick challenge

Autor: Rhonda L. LaFleur, Darby G. Oldenburg, Douglas W. White, Jennifer C. Dant, Steven D. Lovrich, Dean A. Jobe, Steven M Callister

Publikováno v: Journal of Veterinary Diagnostic Investigation. 32:481-485

We characterized the antibody response to decorin-binding protein A (DbpA) or DbpB from immune serum samples collected from 27 dogs infected with Borrelia burgdorferi by Ixodes scapularis ticks. Immunoglobulin M (IgM) antibodies to DbpA or DbpB were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1bedb12e9811d77c76e979872c6c810
https://doi.org/10.1177/1040638720912394

Immediate effect of the COVID-19 pandemic on patient health, health-care use, and behaviours: results from an international survey of people with rheumatic diseases

Autor: Jonathan S Hausmann, Kevin Kennedy, Julia F Simard, Jean W Liew, Jeffrey A Sparks, Tarin T Moni, Carly Harrison, Maggie J Larché, Mitchell Levine, Sebastian E Sattui, Teresa Semalulu, Gary Foster, Salman Surangiwala, Lehana Thabane, Richard P Beesley, Karen L Durrant, Elsa F Mateus, Serena Mingolla, Michal Nudel, Candace A Palmerlee, Dawn P Richards, David F L Liew, Catherine L Hill, Suleman Bhana, Wendy Costello, Rebecca Grainger, Pedro M Machado, Philip C Robinson, Paul Sufka, Zachary S Wallace, Jinoos Yazdany, Emily Sirotich, Philip C. Robinson, Jean W. Liew, Paul H. Sufka, Namrata Singh, Richard A. Howard, Alfred H.J. Kim, Tiffany Westrich-Robertson, Edmund Tsui, Ali Duarte-Garcia, Jeffrey A. Sparks, Herman Tam, Arundathi Jayatilleke, Maximilian F. Konig, Elizabeth R. Graef, Michael S. Putman, Reema H. Syed, Peter Korsten, Elsa Mateus, Sebastian E. Sattui, Zachary S. Wallace, Upton A. Laura, Kilian Adam, Yu Pei Eugenia Chock, Douglas W. White, Geraldine T. Zamora, Lisa S. Traboco, Aarat M. Patel, Manuel F. Ugarte-Gil, Milena A. Gianfrancesco, Isabelle Amigues, Catalina Sanchez-Alvarez, Laura Trupin, Lindsay R. Jacobsohn, Richard P. Beesley, Bimba F. Hoyer, Pedro M. Machado, Kavita Makan, Laure Gossec, Chaudhary Priyank, Jan Leipe, Beth Wallace, Sheila T. Angeles-Han, Ibrahim A. Almaghlouth, Wysham D. Katherine, Anthony S. Padula, Francis Berenbaum, Erin M. Treemarcki, Rashmi Sinha, Laura B. Lewandowski, Kate Webb, Kristen J. Young, Inita Bulina, Sebastian Herrera Uribe, Tamar B. Rubinstein, Marc W. Nolan, Elizabeth Y. Ang, Swamy R. Venuturupalli, Jonathan S. Hausmann, Maureen Dubreuil, Cecilia N. Pisoni, Micaela A. Cosatti, Jose Campos, Julia F. Simard, Richard Conway, Tiffany M. Peterson, Carly O. Harrison, Christele Felix, Dawn P. Richards, Laurie Proulx, Akpabio A. Akpabio, Angus B. Worthing, Lynn R. Laidlaw, Pankti Reid, Candace A. Palmerlee, Maria I. Danila, Lotfi-Emran Sahar, Ngo Q. Linh, Arnav Agarwal, Paul Studenic, David F.L. Liew, Maggie J. Larche, Serena A.M. Mingolla, Erick A. Zamora, Saskya S. Angevare, Rashmi R. Sinha, Karen L.W. Durrant, Andrea Peirce, Emily C. Somers, Laura C. Cappelli, Brittany A. Frankel, Bharat Kumar, Sonia D. Silinsky Krupnikova, Jorge A. Rosario Vega, Jourdan Frankovich, Ruth Fernandez-Ruiz, Marcela Posada Velásquez, Su-Ann Yeoh, Maria Marino, Chrisiaan Scott, Cecilia Rodríguez, Ana I. Martín Mancheño, Philip Seo, Rocío V. Gamboa-Cárdenas, Victor R. Pimentel-Quiroz, Cristina Reátegui-Sokolova, Mari Kihara, Chung M.A. Lin, Dheera Kattula, Girgis Laila, Loreto Carmona, John Wallace, Monique C. Gore-massy, Laura-Ann Tomasella, Moré A. Kodek

Publikováno v: The Lancet. Rheumatology

Background: The impact and consequences of the COVID-19 pandemic on people with rheumatic disease are unclear. We developed the COVID-19 Global Rheumatology Alliance Patient Experience Survey to assess the effects of the COVID-19 pandemic on people w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448fed1950a8b73e8aa3446bf6c5eeb4
http://europepmc.org/articles/PMC8298011