Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Douglas Tsao"'
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e24287 (2011)
Methyltransferases possess a homologous domain that requires both a divalent metal cation and S-adenosyl-L-methionine (SAM) to catalyze its reactions. The kinetics of several methyltransferases has been well characterized; however, the details regard
Externí odkaz:
https://doaj.org/article/5ddaf1b0575749fa98709276cfc0d6eb
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e11936 (2010)
A didactic model is presented to illustrate how the effect of macromolecular crowding on protein folding and association is modeled using current analytical theory and discrete molecular dynamics. While analytical treatments of crowding may consider
Externí odkaz:
https://doaj.org/article/514e4563c1174284a13ab55ab0537a6c
Autor:
Richard Ohrbach, Célia Marisa Rizzatti-Barbosa, Shad B. Smith, Samantha K. Segall, William Maixner, Roger B. Fillingim, Charles Knott, Pekka T. Männistö, Marc Parisien, Douglas Tsao, Josee Gauthier, Joel D. Greenspan, Marjo Piltonen, Carolina B. Meloto, Marino Convertino, Dmitri V. Zaykin, Luda Diatchenko, Ilkka Reenilä, Svetlana A. Shabalina, Nikolay V. Dokholyan, Gary D. Slade
Publikováno v:
Pain
Supplemental Digital Content is Available in the Text. A catechol-O-methyltransferase genetic marker of pain led to the discovery of an alternative enzyme that acts through dopamine rather than epinephrine, characteristic of reference catechol-O-meth
Publikováno v:
The Journal of Physical Chemistry B. 116:8375-8382
Until now it has been impractical to observe protein folding in silico for proteins larger than 50 residues. Limitations of both force field accuracy and computational efficiency make the folding problem very challenging. Here we employ discrete mole
Publikováno v:
Nucleic Acids Research
Catechol-O-methyltransferase (COMT) is a major enzyme controlling catecholamine levels that plays a central role in cognition, affective mood and pain perception. There are three common COMT haplotypes in the human population reported to have functio
Autor:
Douglas Tsao, Jeffrey S. Wieskopf, Samantha K. Segall, Naim U. Rashid, Rachel L. Redler, William Maixner, Luda Diatchenko, Robert E. Sorge, Jeffrey S. Mogil, Nikolay V. Dokholyan
Publikováno v:
Molecular Pain, Vol 8, Iss 1, p 25 (2012)
Molecular Pain
Molecular Pain
The subcutaneous and systemic injection of serotonin reduces cutaneous and visceral pain thresholds and increases responses to noxious stimuli. Different subtypes of 5-hydroxytryptamine (5-HT) receptors are suggested to be associated with different t
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 8, p e24287 (2011)
PLoS ONE, Vol 6, Iss 8, p e24287 (2011)
Methyltransferases possess a homologous domain that requires both a divalent metal cation and S-adenosyl-L-methionine (SAM) to catalyze its reactions. The kinetics of several methyltransferases has been well characterized; however, the details regard
Publikováno v:
Chemical physics letters. 506(4-6)
Catechol O-methyltransferase (COMT) metabolizes catechol moieties by methylating a single hydroxyl group at the meta- or para- hydroxyl position. Hydrophobic amino acids near the active site of COMT influence the regioselectivity of this reaction. Ou
SummaryDiscrete molecular dynamics (DMD) is a rapid sampling method used in protein folding and aggregation studies. Until now, DMD was used to perform simulations of simplified protein models in conjunction with structure-based force fields. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee91ba94514fe13e14b293e26b3c4a5
Autor:
Rong Wang, Alexandros G. Georgakilas, Ronke Adetolu, Esha Gollapalle, Dave C. Francisco, Douglas Tsao, George Sigounas
Publikováno v:
Radiation research. 167(2)
Bistranded oxidative clustered DNA lesions are closely spaced lesions (1-10 bp) that challenge the DNA repair mechanisms and are associated with genomic instability. The endogenous levels of oxidative clustered DNA lesions in cells of human cancer ce