Zobrazeno 1 - 10
of 10 358
pro vyhledávání: '"Douglas T"'
Autor:
Man-Fung Yuen, Scott Fung, Xiaoli Ma, Tuan T. Nguyen, Tarek Hassanein, Hie-Won Hann, Magdy Elkhashab, Ronald G. Nahass, James S. Park, Ira M. Jacobson, Walid S. Ayoub, Steven-Huy Han, Edward J. Gane, Katie Zomorodi, Ran Yan, Julie Ma, Steven J. Knox, Luisa M. Stamm, Maurizio Bonacini, Frank Weilert, Alnoor Ramji, Michael Bennett, Natarajan Ravendhran, Sing Chan, Douglas T. Dieterich, Paul Yien Kwo, Eugene R. Schiff, Ho S. Bae, Jacob Lalezari, Kosh Agarwal, Mark S. Sulkowski
Publikováno v:
JHEP Reports, Vol 6, Iss 4, Pp 100999- (2024)
Background & Aims: The investigational first-generation core inhibitor vebicorvir (VBR) demonstrated safety and antiviral activity over 24 weeks in two phase IIa studies in patients with chronic HBV infection. In this long-term extension study, patie
Externí odkaz:
https://doaj.org/article/79c1f480374a43d2b19433829b3f31b0
Autor:
Daisuke Honda, MD, PhD, Michihiro Hide, MD, PhD, Tomoo Fukuda, MD, PhD, Keisuke Koga, MD, PhD, Eishin Morita, MD, PhD, Shinichi Moriwaki, MD, Yoshihiro Sasaki, MD, PhD, Yusuke Suzuki, MD, PhD, Phil Collis, PhD, Douglas T. Johnston, DO, Dianne Tomita, MPH, Bhavisha Desai, PharmD, Isao Ohsawa, MD, PhD
Publikováno v:
World Allergy Organization Journal, Vol 17, Iss 3, Pp 100882- (2024)
Background: Berotralstat is a once-daily oral inhibitor of plasma kallikrein for the prophylaxis of hereditary angioedema (HAE) in patients ≥12 years. APeX-J aimed to evaluate the efficacy and safety of berotralstat in Japan. Methods: APeX-J was a
Externí odkaz:
https://doaj.org/article/3b4e2445fcc64daeb7ca4e24132a6cc4
Autor:
Melissa Hershman, Karen Torbjornsen, Daniel Pang, Brooke Wyatt, Douglas T. Dieterich, Ponni V. Perumalswami, Andrea D. Branch, Amreen M. Dinani
Publikováno v:
Obesity Science & Practice, Vol 9, Iss 3, Pp 218-225 (2023)
Abstract Objective The Diabetes Prevention Program (DPP) is the gold standard lifestyle modification program that reduces incident type 2 diabetes mellitus. Patients with prediabetes and patients with non‐alcoholic fatty liver disease (NAFLD) often
Externí odkaz:
https://doaj.org/article/8d7dfc381c51418a8726558e99503cb6
Autor:
Milton Pereira, Theresa Ramalho, Warrison A. Andrade, Danielle F. Durso, Maria C. Souza, Katherine A. Fitzgerald, Douglas T. Golenbock, Neal Silverman, Ricardo T. Gazzinelli
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113795- (2024)
Summary: Activation of endosomal Toll-like receptor (TLR) 7, TLR9, and TLR11/12 is a key event in the resistance against the parasite Toxoplasma gondii. Endosomal TLR engagement leads to expression of interleukin (IL)-12 via the myddosome, a protein
Externí odkaz:
https://doaj.org/article/d029504215a5498682a4f974d79d2f97
Autor:
Min Yao, Jonathan Preall, Johannes T.-H. Yeh, Darryl Pappin, Paolo Cifani, Yixin Zhao, Sophia Shen, Philip Moresco, Brian He, Hardik Patel, Amber N. Habowski, Daniel A. King, Kara Raphael, Arvind Rishi, Divyesh Sejpal, Matthew J. Weiss, David Tuveson, Douglas T. Fearon
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
Intratumoral B cell responses are associated with more favorable clinical outcomes in human pancreatic ductal adenocarcinoma (PDAC). However, the antigens driving these B cell responses are largely unknown. We sought to discover these antigens by usi
Externí odkaz:
https://doaj.org/article/ecd02e7631a843fcb9f7b9f96b213e9d
Autor:
Liina Nagirnaja, Alexandra M. Lopes, Wu-Lin Charng, Brian Miller, Rytis Stakaitis, Ieva Golubickaite, Alexandra Stendahl, Tianpengcheng Luan, Corinna Friedrich, Eisa Mahyari, Eloise Fadial, Laura Kasak, Katinka Vigh-Conrad, Manon S. Oud, Miguel J. Xavier, Samuel R. Cheers, Emma R. James, Jingtao Guo, Timothy G. Jenkins, Antoni Riera-Escamilla, Alberto Barros, Filipa Carvalho, Susana Fernandes, João Gonçalves, Christina A. Gurnett, Niels Jørgensen, Davor Jezek, Emily S. Jungheim, Sabine Kliesch, Robert I. McLachlan, Kenan R. Omurtag, Adrian Pilatz, Jay I. Sandlow, James Smith, Michael L. Eisenberg, James M. Hotaling, Keith A. Jarvi, Margus Punab, Ewa Rajpert-De Meyts, Douglas T. Carrell, Csilla Krausz, Maris Laan, Moira K. O’Bryan, Peter N. Schlegel, Frank Tüttelmann, Joris A. Veltman, Kristian Almstrup, Kenneth I. Aston, Donald F. Conrad
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The GEMINI consortium sequenced 1,000 cases of idiopathic male infertility and identified a plausible Mendelian cause in 20% of cases. The infertility genes can be grouped by expression pattern, facilitating their interpretation and follow-up.
Externí odkaz:
https://doaj.org/article/d33757f275f346459883626f17daf68f
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Within the petrochemical industry, accurate measurement of microporosity and its distribution within core samples, particularly those from carbonate reservoirs, has garnered intense interest because studies have suggested that following prim
Externí odkaz:
https://doaj.org/article/d7ab5df81a334d69ae8b074cc566d6ce
Autor:
Richard Opoku, Benson Ahunu, Godwin K.K. Ayetor, Douglas T. Ayitey, Felix Uba, Nana Asiedu, George Y. Obeng
Publikováno v:
Scientific African, Vol 20, Iss , Pp e01583- (2023)
The increasing effect of climate change as a result of CO2 emissions emanating from utilization of conventional energy resources is driving national and regional policies towards global energy transformation in all sectors, including the transportati
Externí odkaz:
https://doaj.org/article/f659cbcebce64a918ff5b8eaed41627d
Autor:
Craig Ades, Moaed A. Abd, Douglas T. Hutchinson, Emmanuelle Tognoli, E Du, Jianning Wei, Erik D. Engeberg
Publikováno v:
Biomimetics, Vol 9, Iss 2, p 78 (2024)
For people who have experienced a spinal cord injury or an amputation, the recovery of sensation and motor control could be incomplete despite noteworthy advances with invasive neural interfaces. Our objective is to explore the feasibility of a novel
Externí odkaz:
https://doaj.org/article/256f2741ddef4b1da797dda02afc293d
Autor:
Robert S. Seitz, Michael E. Hurwitz, Tyler J. Nielsen, Daniel B. Bailey, Matthew G. Varga, Brian Z. Ring, Carrie F. Metts, Brock L. Schweitzer, Kimberly McGregor, Douglas T. Ross
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-11 (2022)
Abstract Background The IO Score is a 27-gene immuno-oncology (IO) classifier that has previously predicted benefit to immune checkpoint inhibitor (ICI) therapy in triple negative breast cancer (TNBC) and non-small cell lung cancer (NSCLC). It genera
Externí odkaz:
https://doaj.org/article/559b3f8416ed47f4ba8dbc1a517b7989