Výsledky vyhledávání - "Douglas S. Gauld"

Inhibition of nitric oxide synthase with pyrazole-1-carboxamidine and related compounds

Autor: Andrew L. Salzman, Donald J. Wolff, Salvatore Cuzzocrea, Andrew Lubeskie, Csaba Szabó, Basilia Zingarelli, Garry J. Southan, Douglas S. Gauld

Publikováno v: Biochemical Pharmacology. 54:409-417

Guanidines, amidines, S-alkylisothioureas, and other compounds containing the amidine function (-C(=NH)NH2) have been described as inhibitors of the generation of nitric oxide (NO) by NO synthase (NOS). Here we report on the inhibition of the activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf665f5ed0f890e7080670cb7cd5d7d3
https://doi.org/10.1016/s0006-2952(97)00196-2

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Inactivation of nitric oxide synthases and cellular nitric oxide formation by N6-iminoethyl-L-lysine and N5-iminoethyl-L-ornithine

Autor: Matthew J. Neulander, Donald J. Wolff, Douglas S Gauld, Andrew Lubeskie

Publikováno v: European journal of pharmacology. 350(2-3)

The kinetics of inactivation of affinity-purified nitric oxide synthase isoforms by N6-iminoethyl-L-lysine (NIL) and N5-iminoethyl-L-ornithine (NIO) has been examined. Each of the agents produced a time and concentration dependent first order inactiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fde805e5bd4675fc691355986965004
https://pubmed.ncbi.nlm.nih.gov/9696424

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