Zobrazeno 1 - 10
of 463
pro vyhledávání: '"Douglas R Spitz"'
Autor:
Kyle C Kloepping, Alora S Kraus, Devin K Hedlund, Colette M Gnade, Brett A Wagner, Michael L McCormick, Melissa A Fath, Dongrim Seol, Tae-Hong Lim, Garry R Buettner, Prabhat C Goswami, F Christopher Pigge, Douglas R Spitz, Michael K Schultz
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244540 (2020)
Despite dramatic improvements in outcomes arising from the introduction of targeted therapies and immunotherapies, metastatic melanoma is a highly resistant form of cancer with 5 year survival rates of
Externí odkaz:
https://doaj.org/article/8a2fd83c241244dfa3511b930ade9fd2
Autor:
Flavio R. Palma, Diego R. Coelho, Kirthi Pulakanti, Marcelo J. Sakiyama, Yunping Huang, Fernando T. Ogata, Jeanne M. Danes, Alison Meyer, Cristina M. Furdui, Douglas R. Spitz, Ana P. Gomes, Benjamin N. Gantner, Sridhar Rao, Vadim Backman, Marcelo G. Bonini
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114415- (2024)
Externí odkaz:
https://doaj.org/article/425e2d4d57dd43c7b3fb3e7ae2f1fbd1
Autor:
Jeanine Schibler, Ann M Tomanek-Chalkley, Jessica L Reedy, Fenghuang Zhan, Douglas R Spitz, Michael K Schultz, Apollina Goel
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0167323 (2016)
Therapeutic advances have markedly prolonged overall survival in multiple myeloma (MM) but the disease currently remains incurable. In a panel of MM cell lines (MM.1S, OPM-2, H929, and U266), using CD138 immunophenotyping, side population staining, a
Externí odkaz:
https://doaj.org/article/00786a4c859c4cfa8403ebcc9c2178af
Autor:
Spenser S. Johnson, Dijie Liu, Jordan T. Ewald, Claudia Robles-Planells, Casey Pulliam, Keegan A. Christensen, Khaliunaa Bayanbold, Brian R. Wels, Shane R. Solst, M. Sue O’Dorisio, Yusuf Menda, Douglas R. Spitz, Melissa A. Fath
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
Thioredoxin Reductase (TrxR) functions to recycle thioredoxin (Trx) during hydroperoxide metabolism mediated by peroxiredoxins and is currently being targeted using the FDA-approved anti-rheumatic drug, auranofin (AF), to selectively sensitize cancer
Externí odkaz:
https://doaj.org/article/c5a3742216384e1498585e82c931ad1b
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96866 (2014)
Calcium uptake through the mitochondrial Ca2+ uniporter (MCU) is thought to be essential in regulating cellular signaling events, energy status, and survival. Functional dissection of the uniporter is now possible through the recent identification of
Externí odkaz:
https://doaj.org/article/5beadb15c71d4faebe8aa30b2458f4a0
Autor:
Kranti A. Mapuskar, Casey F. Pulliam, Ann Tomanek-Chalkley, Prerna Rastogi, Hsiang Wen, Sanjana Dayal, Benjamin R. Griffin, Diana Zepeda-Orozco, Amy L. Sindler, Carryn M. Anderson, Robert Beardsley, Eugene P. Kennedy, Douglas R. Spitz, Bryan G. Allen
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103022- (2024)
Purpose: Cisplatin contributes to acute kidney injury (AKI) and chronic kidney disease (CKD) that occurs with greater frequency and severity in older patients. Age-associated cisplatin sensitivity in human fibroblasts involves increased mitochondrial
Externí odkaz:
https://doaj.org/article/700536df35bc4b5690c5fab7c5eab07c
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50423 (2012)
There are contradictory observations about the different radiosensitivities of cancer stem cells and cancer non-stem cells. To resolve these contradictory observations, we studied radiosensitivities by employing breast cancer stem cell (CSC)-like MDA
Externí odkaz:
https://doaj.org/article/26fde4ac32e74fe8a4c33a21edf0634b
Autor:
Arya Sobhakumari, Laurie Love-Homan, Elise V M Fletcher, Sean M Martin, Arlene D Parsons, Douglas R Spitz, C Michael Knudson, Andrean L Simons
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48175 (2012)
Increased glutathione (GSH) and thioredoxin (Trx) metabolism are mechanisms that are widely implicated in resistance of cancer cells to chemotherapy. The current study determined if simultaneous inhibition of GSH and Trx metabolism enhanced cell kill
Externí odkaz:
https://doaj.org/article/9c3f6038b8924659b32b069d7c274fdd
Autor:
Adam J. Rauckhorst, Gabriela Vasquez Martinez, Gabriel Mayoral Andrade, Hsiang Wen, Ji Young Kim, Aaron Simoni, Claudia Robles-Planells, Kranti A. Mapuskar, Prerna Rastogi, Emily J. Steinbach, Michael L. McCormick, Bryan G. Allen, Navjot S. Pabla, Ashley R. Jackson, Mitchell C. Coleman, Douglas R. Spitz, Eric B. Taylor, Diana Zepeda-Orozco
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101849- (2024)
Objective: Energy-intensive kidney reabsorption processes essential for normal whole-body function are maintained by tubular epithelial cell metabolism. Although tubular metabolism changes markedly following acute kidney injury (AKI), it remains uncl
Externí odkaz:
https://doaj.org/article/3fd3e25948fb47dd89066773a4e94c07
Autor:
Amira Zaher, Kranti A. Mapuskar, Michael S. Petronek, Munir R. Tanas, Alexandra L. Isaacson, Rebecca D. Dodd, Mohammed Milhem, Muhammad Furqan, Douglas R. Spitz, Benjamin J. Miller, Robert A. Beardsley, Bryan G. Allen
Publikováno v:
Antioxidants, Vol 13, Iss 5, p 587 (2024)
Soft tissue sarcomas (STSs) are mesenchymal malignant lesions that develop in soft tissues. Despite current treatments, including radiation therapy (RT) and surgery, STSs can be associated with poor patient outcomes and metastatic recurrences. Neoadj
Externí odkaz:
https://doaj.org/article/b0197ae339824cb0bd61d1901b655ed0