Zobrazeno 1 - 10
of 459
pro vyhledávání: '"Douglas R, Spitz"'
Autor:
Spenser S. Johnson, Dijie Liu, Jordan T. Ewald, Claudia Robles-Planells, Casey Pulliam, Keegan A. Christensen, Khaliunaa Bayanbold, Brian R. Wels, Shane R. Solst, M. Sue O’Dorisio, Yusuf Menda, Douglas R. Spitz, Melissa A. Fath
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
Thioredoxin Reductase (TrxR) functions to recycle thioredoxin (Trx) during hydroperoxide metabolism mediated by peroxiredoxins and is currently being targeted using the FDA-approved anti-rheumatic drug, auranofin (AF), to selectively sensitize cancer
Externí odkaz:
https://doaj.org/article/c5a3742216384e1498585e82c931ad1b
Autor:
Flavio R. Palma, Diego R. Coelho, Kirthi Pulakanti, Marcelo J. Sakiyama, Yunping Huang, Fernando T. Ogata, Jeanne M. Danes, Alison Meyer, Cristina M. Furdui, Douglas R. Spitz, Ana P. Gomes, Benjamin N. Gantner, Sridhar Rao, Vadim Backman, Marcelo G. Bonini
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114415- (2024)
Externí odkaz:
https://doaj.org/article/425e2d4d57dd43c7b3fb3e7ae2f1fbd1
Autor:
Kranti A. Mapuskar, Casey F. Pulliam, Ann Tomanek-Chalkley, Prerna Rastogi, Hsiang Wen, Sanjana Dayal, Benjamin R. Griffin, Diana Zepeda-Orozco, Amy L. Sindler, Carryn M. Anderson, Robert Beardsley, Eugene P. Kennedy, Douglas R. Spitz, Bryan G. Allen
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103022- (2024)
Purpose: Cisplatin contributes to acute kidney injury (AKI) and chronic kidney disease (CKD) that occurs with greater frequency and severity in older patients. Age-associated cisplatin sensitivity in human fibroblasts involves increased mitochondrial
Externí odkaz:
https://doaj.org/article/700536df35bc4b5690c5fab7c5eab07c
Autor:
Amira Zaher, Kranti A. Mapuskar, Michael S. Petronek, Munir R. Tanas, Alexandra L. Isaacson, Rebecca D. Dodd, Mohammed Milhem, Muhammad Furqan, Douglas R. Spitz, Benjamin J. Miller, Robert A. Beardsley, Bryan G. Allen
Publikováno v:
Antioxidants, Vol 13, Iss 5, p 587 (2024)
Soft tissue sarcomas (STSs) are mesenchymal malignant lesions that develop in soft tissues. Despite current treatments, including radiation therapy (RT) and surgery, STSs can be associated with poor patient outcomes and metastatic recurrences. Neoadj
Externí odkaz:
https://doaj.org/article/b0197ae339824cb0bd61d1901b655ed0
Autor:
Adam J. Rauckhorst, Gabriela Vasquez Martinez, Gabriel Mayoral Andrade, Hsiang Wen, Ji Young Kim, Aaron Simoni, Claudia Robles-Planells, Kranti A. Mapuskar, Prerna Rastogi, Emily J. Steinbach, Michael L. McCormick, Bryan G. Allen, Navjot S. Pabla, Ashley R. Jackson, Mitchell C. Coleman, Douglas R. Spitz, Eric B. Taylor, Diana Zepeda-Orozco
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101849- (2024)
Objective: Energy-intensive kidney reabsorption processes essential for normal whole-body function are maintained by tubular epithelial cell metabolism. Although tubular metabolism changes markedly following acute kidney injury (AKI), it remains uncl
Externí odkaz:
https://doaj.org/article/3fd3e25948fb47dd89066773a4e94c07
Autor:
Amira Zaher, Bryce Duchman, Marina Ivanovic, Douglas R. Spitz, Muhammad Furqan, Bryan G. Allen, Michael S. Petronek
Publikováno v:
Bioengineering, Vol 11, Iss 2, p 182 (2024)
Background: Radiation therapy (RT) is an integral and commonly used therapeutic modality for primary lung cancer. However, radiation-induced lung injury (RILI) limits the irradiation dose used in the lung and is a significant source of morbidity. Dis
Externí odkaz:
https://doaj.org/article/d3558ccd26d94b80995a2ce128dbc63f
Autor:
Mekhla Singhania, Amira Zaher, Casey F. Pulliam, Khaliunaa Bayanbold, Charles C. Searby, Joshua D. Schoenfeld, Kranti A. Mapuskar, Melissa A. Fath, Bryan G. Allen, Douglas R. Spitz, Michael S. Petronek
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2398 (2024)
Cancer cells frequently present elevated intracellular iron levels, which are thought to facilitate an enhanced proliferative capacity. Targeting iron metabolism within cancer cells presents an avenue to enhance therapeutic responses, necessitating t
Externí odkaz:
https://doaj.org/article/226bada5cf3345548216f30713cfa0e3
Autor:
Michael S. Petronek, Khaliunaa Bayanbold, Koffi Amegble, Ann M. Tomanek-Chalkley, Bryan G. Allen, Douglas R. Spitz, Charvann K. Bailey
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
A distinctive feature of cancer is the upregulation of sirtuin proteins. Sirtuins are class III NAD+-dependent deacetylases involved in cellular processes such as proliferation and protection against oxidative stress. SIRTs 1 and 2 are also overexpre
Externí odkaz:
https://doaj.org/article/f4c07366773b47248171494537635cee
Autor:
Amira Zaher, Kranti A. Mapuskar, Jann N. Sarkaria, Douglas R. Spitz, Michael S. Petronek, Bryan G. Allen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17158 (2023)
Glioblastoma (GBM), a highly lethal and aggressive central nervous system malignancy, presents a critical need for targeted therapeutic approaches to improve patient outcomes in conjunction with standard-of-care (SOC) treatment. Molecular subtyping b
Externí odkaz:
https://doaj.org/article/c3c19b4b7f9c4bc287ad930bec92d9dd
Autor:
Khaliunaa Bayanbold, Mekhla Singhania, Melissa A. Fath, Charles C. Searby, Jeffrey M. Stolwijk, John B. Henrich, Casey F. Pulliam, Joshua D. Schoenfeld, Kranti A. Mapuskar, Sei Sho, Joseph M. Caster, Bryan G. Allen, Garry R. Buettner, Maria Spies, Prabhat C. Goswami, Michael S. Petronek, Douglas R. Spitz
Publikováno v:
Antioxidants, Vol 12, Iss 11, p 2005 (2023)
The intracellular redox-active labile iron pool (LIP) is weakly chelated and available for integration into the iron metalloproteins that are involved in diverse cellular processes, including cancer cell-specific metabolic oxidative stress. Abnormal
Externí odkaz:
https://doaj.org/article/528679c8946943c59f5691686a352e09