Zobrazeno 1 - 10
of 557
pro vyhledávání: '"Douglas R, Seals"'
Autor:
Kevin O. Murray, Sophia A. Mahoney, Ravinandan Venkatasubramanian, Douglas R. Seals, Zachary S. Clayton
Publikováno v:
Experimental Gerontology, Vol 173, Iss , Pp 112105- (2023)
Age-associated cardiovascular (CV) dysfunction, namely arterial dysfunction, is a key antecedent to the development of CV disease (CVD). Arterial dysfunction with aging is characterized by impaired vascular endothelial function and stiffening of the
Externí odkaz:
https://doaj.org/article/00a14a75deac44d691207513daf2dde3
Autor:
Ester S. Oh, Kaitlin A. Freeberg, Cortney N. Steele, Wei Wang, Heather Farmer‐Bailey, McKinley E. Coppock, Douglas R. Seals, Michel Chonchol, Matthew J. Rossman, Daniel H. Craighead, Kristen L. Nowak
Publikováno v:
Physiological Reports, Vol 11, Iss 1, Pp n/a-n/a (2023)
Abstract Patients with chronic kidney disease (CKD) are more likely to die of cardiovascular diseases, including cerebrovascular disease, than to progress to end‐stage kidney disease. Cerebrovascular dysfunction, characterized by reduced cerebrovas
Externí odkaz:
https://doaj.org/article/983dd108636f4ab587c7b6a264b2479c
Autor:
Kevin O. Murray, Morgan Berryman-Maciel, Sanna Darvish, McKinley E. Coppock, Zhiying You, Michel Chonchol, Douglas R. Seals, Matthew J. Rossman
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Background: Cardiovascular disease (CVD) is the leading cause of death worldwide and aging is the primary risk factor for the development of CVD. The increased risk of CVD with aging is largely mediated by the development of vascular dysfunction. Exc
Externí odkaz:
https://doaj.org/article/783bd6b7a3ba47108798f0a9858cf99d
Autor:
Daniel H. Craighead, Kaitlin A. Freeberg, Narissa P. McCarty, Matthew J. Rossman, Kerrie L. Moreau, Zhiying You, Michel Chonchol, Douglas R. Seals
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Background: High blood pressure (BP), particularly systolic BP (SBP), is the major modifiable risk factor for cardiovascular diseases and related disorders of aging. SBP increases markedly with aging in women such that the prevalence of above-normal
Externí odkaz:
https://doaj.org/article/e2deb17694884274ad2b1b9c550184c9
Publikováno v:
Aging and Cancer, Vol 2, Iss 1-2, Pp 45-69 (2021)
Abstract Cardiovascular diseases (CVD) are the leading cause of death worldwide, and age is by far the greatest risk factor for developing CVD. Vascular dysfunction, including endothelial dysfunction and arterial stiffening, is responsible for much o
Externí odkaz:
https://doaj.org/article/991468460a454cc7a1add6f9e9debae6
Autor:
Kaitlin A. Freeberg, Daniel H. Craighead, Christopher R. Martens, Zhiying You, Michel Chonchol, Douglas R. Seals
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundAging is the primary risk factor for cardiovascular diseases, the leading cause of death worldwide. Age-related increases in systolic blood pressure (SBP) link advancing age to cardiovascular disease risk. A key mechanism mediating the incr
Externí odkaz:
https://doaj.org/article/0ef52ede72374428a40569a5cfac8819
Autor:
Charleen J. Gust, Erin N. Moe, Douglas R. Seals, Marie T. Banich, Jessica R. Andrews-Hanna, Kent E. Hutchison, Angela D. Bryan
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Previous research suggests a marked impact of aging on structural and functional connectivity within the frontoparietal control network (FPCN) and default mode network (DMN). As aging is also associated with reductions in cardiovascular fitness, age-
Externí odkaz:
https://doaj.org/article/ec2d28178b4c4a57ab93518277574905
Autor:
Zachary S. Clayton, PhD, Vienna E. Brunt, PhD, David A. Hutton, BA, Nicholas S. VanDongen, MS, Angelo D’Alessandro, PhD, Julie A. Reisz, PhD, Brian P. Ziemba, PhD, Douglas R. Seals, PhD
Publikováno v:
JACC. CardioOncology, Vol 2, Iss 3, Pp 475-488 (2020)
Background: Doxorubicin (DOXO) chemotherapy increases risk for cardiovascular disease in part by inducing endothelial dysfunction in conduit arteries. However, the mechanisms mediating DOXO-associated endothelial dysfunction in (intact) arteries and
Externí odkaz:
https://doaj.org/article/2689834d7b6241d3a9b0f5e5c561129a
Autor:
Chandani Limbad, Ryosuke Doi, Julia McGirr, Serban Ciotlos, Kevin Perez, Zachary S. Clayton, Radha Daya, Douglas R. Seals, Judith Campisi, Simon Melov
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103848- (2022)
Summary: Cellular senescence is a driver of many age-related pathologies. There is an active search for pharmaceuticals termed senolytics that can mitigate or remove senescent cells in vivo by targeting genes that promote the survival of senescent ce
Externí odkaz:
https://doaj.org/article/14bce5cea8b64b049e1f8d6343cdc4ed
Autor:
Dallin Tavoian, Lupita E. Ramos-Barrera, Daniel H. Craighead, Douglas R. Seals, Edward J. Bedrick, Joseph S. Alpert, Saif Mashaqi, E. Fiona Bailey
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Background: Cardiovascular disease is a major global health concern and prevalence is high in adults with obstructive sleep apnea (OSA). Lowering blood pressure (BP) can greatly reduce cardiovascular disease risk and physical activity is routinely pr
Externí odkaz:
https://doaj.org/article/4dd758ee9016457b9c2a91ade99ab5bb