Zobrazeno 1 - 10 of 654 pro vyhledávání: '"Douglas R, Green"'
1
Akademický článek
Not dead yet: cell death and survival in cancer and normal physiology
Autor: Douglas R. Green
Publikováno v: Frontiers in Cell Death, Vol 3 (2024)
For decades, we have assumed that all regulated cell death pathways have a dedicated “point of no return” that precedes death but after which cells are committed to die. The realization that this is often not the case represents what can be consi
Externí odkaz: https://doaj.org/article/ecb720d7f1fd425196fb066128ec047d
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2
Akademický článek
The interaction between RIPK1 and FADD controls perinatal lethality and inflammation
Autor: Diego A. Rodriguez, Bart Tummers, Jeremy J.P. Shaw, Giovanni Quarato, Ricardo Weinlich, James Cripps, Patrick Fitzgerald, Laura J. Janke, Stephane Pelletier, Jeremy Chase Crawford, Douglas R. Green
Publikováno v: Cell Reports, Vol 43, Iss 6, Pp 114335- (2024)
Summary: Perturbation of the apoptosis and necroptosis pathways critically influences embryogenesis. Receptor-associated protein kinase-1 (RIPK1) interacts with Fas-associated via death domain (FADD)-caspase-8-cellular Flice-like inhibitory protein l
Externí odkaz: https://doaj.org/article/1e0db83b24f847f8b7f218099ee40210
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3
Akademický článek
Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer’s disease and aging
Autor: Bidur Paudel, Si-Yeon Jeong, Carolina Pena Martinez, Alexis Rickman, Ashley Haluck-Kangas, Elizabeth T. Bartom, Kristina Fredriksen, Amira Affaneh, John A. Kessler, Joseph R. Mazzulli, Andrea E. Murmann, Emily Rogalski, Changiz Geula, Adriana Ferreira, Bradlee L. Heckmann, Douglas R. Green, Katherine R. Sadleir, Robert Vassar, Marcus E. Peter
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Alzheimer’s disease (AD) is characterized by progressive neurodegeneration, but the specific events that cause cell death remain poorly understood. Death Induced by Survival gene Elimination (DISE) is a cell death mechanism mediated by sho
Externí odkaz: https://doaj.org/article/64dd0289c30a4bcf9ae00fb8857f2f61
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7
Akademický článek
Rubicon-deficiency sensitizes mice to mixed lineage kinase domain-like (MLKL)-mediated kidney ischemia-reperfusion injury
Autor: Wulf Tonnus, Sophie Locke, Claudia Meyer, Francesca Maremonti, Lena Eggert, Anne von Mässenhausen, Stefan R. Bornstein, Douglas R. Green, Andreas Linkermann
Publikováno v: Cell Death and Disease, Vol 13, Iss 3, Pp 1-9 (2022)
Abstract The cytosolic protein rubicon (RUBCN) has been implicated in the removal of necrotic debris and autoimmunity. However, the role of RUBCN in models of acute kidney injury (AKI), a condition that typically involves necrotic kidney tubules, was
Externí odkaz: https://doaj.org/article/e5aa39e802b1426184909657e90e24bb
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8
Akademický článek
c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration
Autor: Alexis Martinez, Cristian M. Lamaizon, Cristian Valls, Fabien Llambi, Nancy Leal, Patrick Fitzgerald, Cliff Guy, Marcin M. Kamiński, Nibaldo C. Inestrosa, Brigitte van Zundert, Gonzalo I. Cancino, Andrés E. Dulcey, Silvana Zanlungo, Juan J. Marugan, Claudio Hetz, Douglas R. Green, Alejandra R. Alvarez
Publikováno v: Antioxidants, Vol 12, Iss 11, p 2007 (2023)
The endoplasmic reticulum is a subcellular organelle key in the control of synthesis, folding, and sorting of proteins. Under endoplasmic reticulum stress, an adaptative unfolded protein response is activated; however, if this activation is prolonged
Externí odkaz: https://doaj.org/article/52442aebd7684326868078bfe18e45e8
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