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pro vyhledávání: '"Douglas P Izmirian"'
Autor:
Karl O.A. Yu, Mitchell Kronenberg, Douglas P Izmirian, Amy R. Howell, Archana Khurana, Stewart K Richardson, Steven A Porcelli, Matthew F Dunn, Rachel M. Ndonye
Publikováno v:
The Journal of Organic Chemistry. 70:10260-10270
[structures: see text] The phytosphingosine-containing alpha-galactosylceramides (alpha-GalCers), KRN7000 and OCH, have been shown to activate NKT cells via interaction with CD1d, a member of the CD1 family of antigen presenting proteins. Evidence fr
Autor:
Amy R. Howell, Rachel M. Ndonye, Stewart K. Richardson, Douglas P Izmirian, Robyn L. Guerrera, Regina C. So
Publikováno v:
ChemInform. 35
Autor:
Douglas P Izmirian, Regina C. So, Robyn L. Guerrera, Rachel M. Ndonye, Stewart K. Richardson, Amy R. Howell
Publikováno v:
The Journal of organic chemistry. 69(9)
Sphinganines can be synthesized in just three steps from easily prepared serine-derived Weinreb amide 4. Pre-deprotonation of the acidic (N-H and O-H) protons of 4 allows for its efficient conversion to amino ketones 5. Such ketones can be selectivel