Zobrazeno 1 - 10
of 573
pro vyhledávání: '"Douglas P, Kiel"'
Autor:
Simone Radavelli-Bagatini, Catherine P. Bondonno, Jack Dalla Via, Marc Sim, Abadi K. Gebre, Lauren C. Blekkenhorst, Emma L. Connolly, Nicola P. Bondonno, John T. Schousboe, Richard J. Woodman, Kun Zhu, Shelby Mullin, Pawel Szulc, Ben Jackson, James Dimmock, Markus P. Schlaich, Kay L. Cox, Douglas P. Kiel, Wai H. Lim, Mandy Stanley, Amanda Devine, Peter L. Thompson, Evan J. Williams, Lisa G. Wood, Moira Sim, Robin M. Daly, Jonathan M. Hodgson, Joshua R. Lewis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Provision of non-invasive vascular imaging results to individuals has been shown to improve cardiovascular disease risk factor control: its impact on diet remains uncertain. In this two-arm, single-blind, parallel, 12-week randomized control
Externí odkaz:
https://doaj.org/article/179c602b0bbe41d3b629c7ce1a16ccf6
Autor:
Amena Keshawarz, Roby Joehanes, Jiantao Ma, Gha Young Lee, Ricardo Costeira, Pei-Chien Tsai, Olatz M. Masachs, Jordana T. Bell, Rory Wilson, Barbara Thorand, Juliane Winkelmann, Annette Peters, Jakob Linseisen, Melanie Waldenberger, Terho Lehtimäki, Pashupati P. Mishra, Mika Kähönen, Olli Raitakari, Mika Helminen, Carol A. Wang, Phillip E. Melton, Rae-Chi Huang, Craig E. Pennell, Therese A. O’Sullivan, Carolina Ochoa-Rosales, Trudy Voortman, Joyce B.J. van Meurs, Kristin L. Young, Misa Graff, Yujie Wang, Douglas P. Kiel, Caren E. Smith, Paul F. Jacques, Daniel Levy
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
Background: Dietary intake of antioxidants such as vitamins C and E protect against oxidative stress, and may also be associated with altered DNA methylation patterns. Methods: We meta-analysed epigenome-wide association study (EWAS) results from 11,
Externí odkaz:
https://doaj.org/article/452ff36e0dfe4a91b10b276612bb1831
Autor:
Kaleen N. Hayes, Tingting Zhang, Dae Hyun Kim, Lori A. Daiello, Yoojin Lee, Douglas P. Kiel, Sarah D. Berry, Andrew R. Zullo
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 21 (2023)
Background Dose reduction of direct oral anticoagulant (DOAC) medications is inconsistently applied to older adults with multiple morbidities, potentially due to perceived harms and unknown benefits of standard dosing. Methods and Results Using 2013
Externí odkaz:
https://doaj.org/article/edbc5915d6bc4b849c3463cf19e48891
Autor:
Paul C. Okoro, Eric S. Orwoll, Curtis Huttenhower, Xochitl Morgan, Thomas M. Kuntz, Lauren J. McIver, Alyssa B. Dufour, Mary L. Bouxsein, Lisa Langsetmo, Samaneh Farsijani, Deborah M. Kado, Roberto Pacifici, Shivani Sahni, Douglas P. Kiel
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
The gut microbiome affects the inflammatory environment through effects on T-cells, which influence the production of immune mediators and inflammatory cytokines that stimulate osteoclastogenesis and bone loss in mice. However, there are few large hu
Externí odkaz:
https://doaj.org/article/21de9cfc7b5146db86ebd778fa80cd4e
Autor:
Naeha Sharif, Syed Zulqarnain Gilani, David Suter, Siobhan Reid, Pawel Szulc, Douglas Kimelman, Barret A. Monchka, Mohammad Jafari Jozani, Jonathan M. Hodgson, Marc Sim, Kun Zhu, Nicholas C. Harvey, Douglas P. Kiel, Richard L. Prince, John T. Schousboe, William D. Leslie, Joshua R. Lewis
Publikováno v:
EBioMedicine, Vol 94, Iss , Pp 104676- (2023)
Summary: Background: Lateral spine images for vertebral fracture assessment can be easily obtained on modern bone density machines. Abdominal aortic calcification (AAC) can be scored on these images by trained imaging specialists to assess cardiovasc
Externí odkaz:
https://doaj.org/article/31cd3882906e49e1b0041f9fff2c5938
Autor:
M d Mesbah Uddin, Ngoc Quynh H. Nguyen, Bing Yu, Jennifer A. Brody, Akhil Pampana, Tetsushi Nakao, Myriam Fornage, Jan Bressler, Nona Sotoodehnia, Joshua S. Weinstock, Michael C. Honigberg, Daniel Nachun, Romit Bhattacharya, Gabriel K. Griffin, Varuna Chander, Richard A. Gibbs, Jerome I. Rotter, Chunyu Liu, Andrea A. Baccarelli, Daniel I. Chasman, Eric A. Whitsel, Douglas P. Kiel, Joanne M. Murabito, Eric Boerwinkle, Benjamin L. Ebert, Siddhartha Jaiswal, James S. Floyd, Alexander G. Bick, Christie M. Ballantyne, Bruce M. Psaty, Pradeep Natarajan, Karen N. Conneely
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Clonal hematopoiesis, often caused by mutations in DNMT3A and TET2, is associated with blood cancer and coronary artery disease. Here, the authors conduct an epigenome-wide association study, finding that clonal hematopoiesis caused by DNMT3A vs. TET
Externí odkaz:
https://doaj.org/article/c22e81f057bd44ef857ef1b82f628c5a
Autor:
Kaare M. Gautvik, Daniel Sachse, Alexandra C. Hinton, Ole K. Olstad, Douglas P. Kiel, Yi-Hsiang Hsu, Tor P. Utheim, Christine W. Lary, Sjur Reppe
Publikováno v:
BMC Genomic Data, Vol 23, Iss 1, Pp 1-6 (2022)
Abstract Background Physical molecular interactions are the basis of intracellular signalling and gene regulatory networks, and comprehensive, accessible databases are needed for their discovery. Highly correlated transcripts may reflect important fu
Externí odkaz:
https://doaj.org/article/b6fee24839894841a8bd818e1d58c5b1
Publikováno v:
Nutrition Journal, Vol 21, Iss 1, Pp 1-8 (2022)
Abstract Background Previous studies reported that dairy foods are associated with higher areal bone mineral density (BMD) in older adults. However, data on bone texture are lacking. We determined the association of dairy food intake (milk, yogurt, c
Externí odkaz:
https://doaj.org/article/3019a984905249b6a414867b75d7d240
Autor:
Garan Jones, Katerina Trajanoska, Adam J. Santanasto, Najada Stringa, Chia-Ling Kuo, Janice L. Atkins, Joshua R. Lewis, ThuyVy Duong, Shengjun Hong, Mary L. Biggs, Jian’an Luan, Chloe Sarnowski, Kathryn L. Lunetta, Toshiko Tanaka, Mary K. Wojczynski, Ryan Cvejkus, Maria Nethander, Sahar Ghasemi, Jingyun Yang, M. Carola Zillikens, Stefan Walter, Kamil Sicinski, Erika Kague, Cheryl L. Ackert-Bicknell, Dan E. Arking, B. Gwen Windham, Eric Boerwinkle, Megan L. Grove, Misa Graff, Dominik Spira, Ilja Demuth, Nathalie van der Velde, Lisette C. P. G. M. de Groot, Bruce M. Psaty, Michelle C. Odden, Alison E. Fohner, Claudia Langenberg, Nicholas J. Wareham, Stefania Bandinelli, Natasja M. van Schoor, Martijn Huisman, Qihua Tan, Joseph Zmuda, Dan Mellström, Magnus Karlsson, David A. Bennett, Aron S. Buchman, Philip L. De Jager, Andre G. Uitterlinden, Uwe Völker, Thomas Kocher, Alexander Teumer, Leocadio Rodriguéz-Mañas, Francisco J. García, José A. Carnicero, Pamela Herd, Lars Bertram, Claes Ohlsson, Joanne M. Murabito, David Melzer, George A. Kuchel, Luigi Ferrucci, David Karasik, Fernando Rivadeneira, Douglas P. Kiel, Luke C. Pilling
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Muscle weakness has been associated with morbidity and mortality in older people. Here, the authors have investigated this trait further by performing a genome-wide meta-analysis of grip strength and Mendelian randomization to discover causal relatio
Externí odkaz:
https://doaj.org/article/c432b68fa4c74f79a795551d0b9372a0
Autor:
Nicholas D. Johnson, Luoxiu Huang, Ronghua Li, Yun Li, Yuchen Yang, Hye Rim Kim, Crystal Grant, Hao Wu, Eric A. Whitsel, Douglas P. Kiel, Andrea A. Baccarelli, Peng Jin, Joanne M. Murabito, Karen N. Conneely
Publikováno v:
Epigenetics, Vol 15, Iss 3, Pp 294-306 (2020)
DNA methylation (DNAm) has a well-established association with age in many tissues, including peripheral blood mononuclear cells (PBMCs). Compared to DNAm, the closely related epigenetic modification known as DNA hydroxymethylation (DNAhm) was much m
Externí odkaz:
https://doaj.org/article/deb066c073874d2193e14b508087241d