Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Douglas O. Sobel"'
Publikováno v:
Islets
Immortalized beta cells are an abundant source of insulin-producing cells. Although MIN-6 cells have similar characteristics as normal islets in vitro, the in vivo use of MIN-6 cells has not been fully described. This study characterizes in vivo mous
Autor:
Stefan Schneider, Bruce G. Simons-Morton, Denise L. Haynie, Douglas O. Sobel, Tonja R. Nansel, Ronald J. Iannotti
Publikováno v:
Journal of Pediatric Psychology. 34:283-293
Objective The initial validation of a brief assessment of a diabetes-specific self-esteem dimension in adolescents with type 1 diabetes. Methods Youths with type 1 diabetes (n = 87) aged 10–16 years were administered the multidimensional Self-Estee
Publikováno v:
Autoimmunity. 41:543-553
Interferon-alpha (IFN-alpha) inhibits the development of diabetes in animal models of autoimmune diabetes. However, the mechanism of the action is not fully understood and drug toxicity could limit its potential clinical utility. Interferon-tau (IFN-
Autor:
Stefan Schneider, Denise L. Haynie, Tonja R. Nansel, Bruce G. Simons-Morton, Douglas O. Sobel, Loretta M. Clark, Leslie P. Plotnick, Linda Zeitzoff, Ronald J. Iannotti
Publikováno v:
Diabetes Care. 30:1107-1112
OBJECTIVE—Using a profile-based approach to the assessment of diabetes management, the purpose of this study was to identify and evaluate an empirically derived classification system of distinct self-management styles. RESEARCH DESIGN AND METHODS
Publikováno v:
Journal of Autoimmunity. 19:129-137
Gamma interferon (IFN-gamma) has been thought to play an important role in the pathogenesis of diabetes. This report determines if rIFN-gamma administration to NOD mice paradoxically inhibits the development of diabetes. Injections of recombinant rIF
Autor:
Young Hwa Chung, David M. Harlan, Ji-Won Yoon, Behrouz Ahvazi, Adam Bagg, Douglas O. Sobel, Deepshika Goyal
Publikováno v:
Journal of Autoimmunity. 11:343-352
Poly I:C, an inducer of IFN-alpha and other cytokines, has been used to study the development of diabetes in both the BioBreeding (BB) diabetes prone rat and non-obese diabetic (NOD) mouse animal models of insulin-dependent diabetes mellitus (IDDM).
Publikováno v:
Journal of Autoimmunity. 10:387-394
A 52 kDa islet protein has recently been identified as the target of autoantibodies in the NOD mouse model of IDDM and humans with IDDM. However, the presence of T cell immunity against the 52 kDa islet protein in IDDM has not been reported. We repor
Autor:
Val Abbassi, Norio Azumi, Daniel A. Holterman, Owen C. Blair, John C. Hiserodt, Joseph A. Bellanti, Karen Creswell, Douglas O. Sobel
Publikováno v:
Journal of Autoimmunity. 8:843-857
The development of insulin dependent diabetes mellitus (IDDM) and diabetes in the diabetes prone (DP) BB rat animal model of IDDM is thought to be due to an autoimmune process. Natural killer (NK) cells have been implicated but not proven to play a p
Publikováno v:
Clinical Pediatrics. 33:556-560
Autor:
Jeffrey L. Rossio, Douglas O. Sobel, Joseph A. Bellanti, Val Abbassi, Barbara J. Zeligs, Cynthia H Ewel
Publikováno v:
Diabetes. 43:518-522
Although the administration of a fixed dose of the α-interferon (α-IFN) inducer, polyinosinic polycytidilic acid (poly I:C), accelerates the development of diabetes in DP-BB rats, no reports have characterized the dose-response relationship of poly