Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Douglas O. Escrivani"'
Autor:
Douglas O Escrivani, Rebecca L Charlton, Marjolly B Caruso, Gabriela A Burle-Caldas, Maria Paula G Borsodi, Russolina B Zingali, Natalia Arruda-Costa, Marcos V Palmeira-Mello, Jéssica B de Jesus, Alessandra M T Souza, Bárbara Abrahim-Vieira, Stefanie Freitag-Pohl, Ehmke Pohl, Paul W Denny, Bartira Rossi-Bergmann, Patrick G Steel
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009951 (2021)
With current drug treatments failing due to toxicity, low efficacy and resistance; leishmaniasis is a major global health challenge that desperately needs new validated drug targets. Inspired by activity of the natural chalcone 2',6'-dihydroxy-4'-met
Externí odkaz:
https://doaj.org/article/97dcebeea4914662b9ca60f477d72118
Autor:
Elaine Soares Coimbra, Suzana Passos Chaves, Douglas O Escrivani, Herbert Leonel de Matos Guedes, Bartira Rossi-Bergmann, Daniel Cláudio de Oliveira Gomes, Patrícia de Almeida Machado
Publikováno v:
Parasitology
Vitamin D has been reported to activate macrophage microbicidal mechanisms by inducing the production of antimicrobial peptides and nitric oxide (NO), but conversely has been shown to contribute to a greater susceptibility to Leishmania amazonensis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aca884ad6d7a9f1cccf625f597702b5
https://doi.org/10.1017/s0031182020001791
https://doi.org/10.1017/s0031182020001791
Autor:
John G. Mina, Emily A. Dickie, Edubiel A. Alpizar-Sosa, Paul W. Denny, Chris Brown, Maria Paula Gonçalves Borsodi, Cláudia P. Figueiredo, Wenbin Wei, Robson Coutinho-Silva, Douglas O. Escrivani, Emanuelle V. de Lima, Bartira Rossi-Bergmann, Andy Merritt, Amjed Qays Al-Qaisi, Patrick G. Steel, Michael P. Barrett, Rebecca L Charlton, Terry K. Smith
Publikováno v:
ACS infectious diseases, 2021, Vol.7(1), pp.47-63 [Peer Reviewed Journal]
We thank CNPq (PVE Grant: 400894/2014-9 to B.R.-B. and P.G.S.), The Royal Society (The Royal Society International Collaboration Awards for Research Professors 2016: IC160044 to B.R.-B. and P.G.S.), MRC (iCASE studentship for C.B.; Grant MR/M020118/1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68269bc68eb5c08c88f7c95185bf53a9
https://hdl.handle.net/10023/21321
https://hdl.handle.net/10023/21321
Publikováno v:
Topics in Medicinal Chemistry ISBN: 9783031068492
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfc940414dfaa684854c7b69fb2f8a77
https://doi.org/10.1007/7355_2021_134
https://doi.org/10.1007/7355_2021_134
Autor:
John G M, Mina, Rebecca L, Charlton, Edubiel, Alpizar-Sosa, Douglas O, Escrivani, Christopher, Brown, Amjed, Alqaisi, Maria Paula G, Borsodi, Claudia P, Figueiredo, Emanuelle V, de Lima, Emily A, Dickie, Wenbin, Wei, Robson, Coutinho-Silva, Andy, Merritt, Terry K, Smith, Michael P, Barrett, Bartira, Rossi-Bergmann, Paul W, Denny, Patrick G, Steel
Publikováno v:
ACS Infectious Diseases
Current chemotherapeutics for leishmaniasis have multiple deficiencies, and there is a need for new safe, efficacious, and affordable medicines. This study describes a successful drug repurposing approach that identifies the over-the-counter antihist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32b04de81c5c385197e8530b2453b645
https://pubmed.ncbi.nlm.nih.gov/33291887
https://pubmed.ncbi.nlm.nih.gov/33291887
Autor:
Franceline Reynaud, Natalia Arruda-Costa, Ariane de Jesus Sousa-Batista, Patrick G. Steel, Douglas O Escrivani, Bartira Rossi-Bergmann
Publikováno v:
Parasitology
Parasitology, 2020, Vol.147(9), pp.1032-1037 [Peer Reviewed Journal]
Parasitology, 2020, Vol.147(9), pp.1032-1037 [Peer Reviewed Journal]
Cutaneous leishmaniasis (CL) is a major health problem in many countries and its current treatment involves multiple parenteral injections with toxic drugs and requires intensive health services. Previously, the efficacy of a single subcutaneous inje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64d91c29aaecc35f3478f5cad2e0cda
https://europepmc.org/articles/PMC10317656/
https://europepmc.org/articles/PMC10317656/
Anti-parasitic effect of the diuretic and Na+-ATPAse inhibitor furosemide in cutaneous leishmaniasis
Autor:
E E Almeida-Amaral, José Roberto Meyer-Fernandes, Bartira Rossi-Bergmann, Douglas O Escrivani, Natalia Arruda-Costa
Publikováno v:
Parasitology. 144:1375-1383
SUMMARYLeishmania amazonensispromastigotes are known to express furosemide (Lasix®)-sensitiveP-type membrane Na+-ATPase. In the present study, furosemide activity was studied in intracellular amastigotes and infected BALB/c mice to investigate its e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541f54de2916548f1a7fdb2cea84619e
https://doi.org/10.1017/s0031182017000695
https://doi.org/10.1017/s0031182017000695
Autor:
Stela Regina Ferrarini, Fernanda Poletto, Patrick G. Steel, Bartira Rossi-Bergmann, Ariane de Jesus Sousa-Batista, Milene V. Lopes, Silvia Stanisçuaski Guterres, Douglas O Escrivani, Adriana Raffin Pohlmann
Publikováno v:
Nanomedicine : nanotechnology, biology and medicine, 2020, Vol.24, pp.102121 [Peer Reviewed Journal]
Cutaneous leishmaniasis (CL) is a neglected parasitic disease conventionally treated by multiple injections with systemically toxic drugs. Aiming at a more acceptable therapy, we developed lipid-core nanocapsules (LNCs) entrapping the potent antileis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b805c110db8d44e8180e3016dffbd88c
https://pubmed.ncbi.nlm.nih.gov/31672601
https://pubmed.ncbi.nlm.nih.gov/31672601