Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Douglas Myers-Turnbull"'
Autor:
Tomiko Oskotsky, Ruchika Bajaj, Jillian Burchard, Taylor Cavazos, Ina Chen, William T Connell, Stephanie Eaneff, Tianna Grant, Ishan Kanungo, Karla Lindquist, Douglas Myers-Turnbull, Zun Zar Chi Naing, Alice Tang, Bianca Vora, Jon Wang, Isha Karim, Claire Swadling, Janice Yang, AI4ALL Student Cohort, Bill Lindstaedt, Marina Sirota
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 1, p e1009719 (2022)
Artificial Intelligence (AI) has the power to improve our lives through a wide variety of applications, many of which fall into the healthcare space; however, a lack of diversity is contributing to limitations in how broadly AI can help people. The U
Externí odkaz:
https://doaj.org/article/9eb92fe2d71245fd98d4d1c22da4774f
Autor:
Matthew N. McCarroll, Leo Gendelev, Reid Kinser, Jack Taylor, Giancarlo Bruni, Douglas Myers-Turnbull, Cole Helsell, Amanda Carbajal, Capria Rinaldi, Hye Jin Kang, Jung Ho Gong, Jason K. Sello, Susumu Tomita, Randall T. Peterson, Michael J. Keiser, David Kokel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Some anesthetics despite being generally associated with sedation, can also increase brain activity—a phenomenon called paradoxical excitation. The authors identified dozens of compounds that generally decrease neuronal activity, but increase activ
Externí odkaz:
https://doaj.org/article/800557a8a9ec49a7a80e98ddf53a8be2
Autor:
Aleix Lafita, Spencer Bliven, Andreas Prlić, Dmytro Guzenko, Peter W Rose, Anthony Bradley, Paolo Pavan, Douglas Myers-Turnbull, Yana Valasatava, Michael Heuer, Matt Larson, Stephen K Burley, Jose M Duarte
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 2, p e1006791 (2019)
BioJava is an open-source project that provides a Java library for processing biological data. The project aims to simplify bioinformatic analyses by implementing parsers, data structures, and algorithms for common tasks in genomics, structural biolo
Externí odkaz:
https://doaj.org/article/5c110558d5a8402a913e0beeea63fb8e
Autor:
David Mavor, Kyle A. Barlow, Daniel Asarnow, Yuliya Birman, Derek Britain, Weilin Chen, Evan M. Green, Lillian R. Kenner, Bruk Mensa, Leanna S. Morinishi, Charlotte A. Nelson, Erin M. Poss, Pooja Suresh, Ruilin Tian, Taylor Arhar, Beatrice E. Ary, David P. Bauer, Ian D. Bergman, Rachel M. Brunetti, Cynthia M. Chio, Shizhong A. Dai, Miles S. Dickinson, Susanna K. Elledge, Cole V. M. Helsell, Nathan L. Hendel, Emily Kang, Nadja Kern, Matvei S. Khoroshkin, Lisa L. Kirkemo, Greyson R. Lewis, Kevin Lou, Wesley M. Marin, Alison M. Maxwell, Peter F. McTigue, Douglas Myers-Turnbull, Tamas L. Nagy, Andrew M. Natale, Keely Oltion, Sergei Pourmal, Gabriel K. Reder, Nicholas J. Rettko, Peter J. Rohweder, Daniel M. C Schwarz, Sophia K. Tan, Paul V. Thomas, Ryan W. Tibble, Jason P. Town, Mary K. Tsai, Fatima S. Ugur, Douglas R. Wassarman, Alexander M. Wolff, Taia S. Wu, Derek Bogdanoff, Jennifer Li, Kurt S. Thorn, Shane O'Conchúir, Danielle L. Swaney, Eric D. Chow, Hiten D. Madhani, Sy Redding, Daniel N. Bolon, Tanja Kortemme, Joseph L. DeRisi, Martin Kampmann, James S. Fraser
Publikováno v:
Biology Open, Vol 7, Iss 7 (2018)
Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it is highly tolerant to mutation during selection experiments performed in the laboratory. We have proposed that this discrepancy results from the di
Externí odkaz:
https://doaj.org/article/120375a9425d4b15800ba82e59af4543
Autor:
Arya Azinfar, David E. Olson, Lindsay P. Cameron, Douglas Myers-Turnbull, Lee E. Dunlap, David Kokel, Ana Cristina Grodzki, Calvin Ly, Jack C. Taylor, Robert J. Tombari, Jayashri Viswanathan, Pamela J. Lein
Publikováno v:
Journal of Medicinal Chemistry. 63:1142-1155
Ketamine, N,N-dimethyltryptamine (DMT), and other psychoplastogens possess enormous potential as neurotherapeutics due to their ability to potently promote neuronal growth. Here, we report the first-ever structure-activity relationship study with the
Autor:
Lindsay P. Cameron, Douglas Myers-Turnbull, Jayashri Viswanathan, Oliver Fiehn, Zachary Rabow, Guoliang Zhang, David E. Olson, Bianca Yaghoobi, Zefan Q. Hurley, Brandon M. Brown, Jamie Peters, David Kokel, Maxemiliano V. Vargas, Robert J. Tombari, Lauren J. Laskowski, Matthew N. McCarroll, John D. McCorvy, Alexander J. Pell, Taohui Liu, Pamela J. Lein, Jack C. Taylor, Yi Zuo, Ju Lu, Yann Ehinger, Michelle Tjia, Heike Wulff, Emilie I. Anderson, Lee E. Dunlap, Dorit Ron
Publikováno v:
Nature, vol 589, iss 7842
Nature
Nature
The psychedelic alkaloid ibogaine has anti-addictive properties in both humans and animals1. Unlike most medications for the treatment of substance use disorders, anecdotal reports suggest that ibogaine has the potential to treat addiction to various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac37c443462daef2d948da379f29fb96
https://escholarship.org/uc/item/5pp1d1vm
https://escholarship.org/uc/item/5pp1d1vm
Autor:
Lee E, Dunlap, Arya, Azinfar, Calvin, Ly, Lindsay P, Cameron, Jayashri, Viswanathan, Robert J, Tombari, Douglas, Myers-Turnbull, Jack C, Taylor, Ana Cristina, Grodzki, Pamela J, Lein, David, Kokel, David E, Olson
Publikováno v:
J Med Chem
Ketamine, N,N-dimethyltryptamine (DMT), and other psychoplastogens possess enormous potential as neurotherapeutics due to their ability to potently promote neuronal growth. Here, we report the first-ever structure-activity relationship study with the
Autor:
Douglas Myers-Turnbull, Jack C Taylor, Cole Helsell, Matthew N McCarroll, Chris S Ki, Tia A Tummino, Shreya Ravikumar, Reid Kinser, Leo Gendelev, Rebekah Alexander, Michael J Keiser, David Kokel
Purpose Compounds that act on the central nervous system (CNS) are crucial tools in drug discovery and neuroscience. To discover compounds with novel mechanisms of action, researchers have developed behavioral screens in larval zebrafish including va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9d38f3ac1518d69a76453d0973bde61
https://doi.org/10.1101/2020.01.01.891432
https://doi.org/10.1101/2020.01.01.891432
Autor:
Capria Rinaldi, Leo Gendelev, Randall T. Peterson, Reid Kinser, Cole Helsell, Giancarlo N. Bruni, Jack C. Taylor, Matthew N. McCarroll, Amanda Carbajal, Jung Ho Gong, Douglas Myers-Turnbull, Jason K. Sello, David Kokel, Hye Jin Kang, Michael J. Keiser, Susumu Tomita
Publikováno v:
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Anesthetics are generally associated with sedation, but some anesthetics can also increase brain and motor activity—a phenomenon known as paradoxical excitation. Previous studies have identified GABAA receptors as the primary targets of most anesth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58cc30638eaa09534fd1afd3af00f04d
https://escholarship.org/uc/item/8vz8j9rq
https://escholarship.org/uc/item/8vz8j9rq
Autor:
Danielle L. Swaney, Alexander M. Wolff, Tamas L. Nagy, Douglas Myers-Turnbull, Douglas R. Wassarman, Kyle A. Barlow, Paul V. Thomas, Rachel M. Brunetti, Derek Britain, Kevin Lou, Sy Redding, Wesley M. Marin, Mary K. Tsai, Kurt S. Thorn, Ryan W. Tibble, Lillian R. Kenner, Daniel M. C. Schwarz, Charlotte A. Nelson, Bruk Mensa, Fatima S. Ugur, Derek Bogdanoff, Taia S. Wu, E. Kang, Nicholas J. Rettko, Leanna S. Morinishi, Peter F. McTigue, Martin Kampmann, Gabriel K. Reder, Eric D. Chow, Alison M Maxwell, Jason Town, James S. Fraser, Andrew M. Natale, David P. Bauer, Cole Helsell, Joseph L. DeRisi, Yuliya Birman, Pooja Suresh, Evan M. Green, Ruilin Tian, Jennifer Y. Li, Sergei Pourmal, Weilin Chen, Hiten D. Madhani, Daniel N. Bolon, Miles Sasha Dickinson, Shane O’Conchúir, Keely Oltion, Daniel Asarnow, Peter J. Rohweder, Susanna K. Elledge, David Mavor, Erin M. Poss, Matvei S. Khoroshkin, Beatrice Ary, Ian D. Bergman, Nadja Kern, Taylor Arhar, Lisa L. Kirkemo, Tanja Kortemme, Sophia K. Tan, Shizhong Dai, Greyson R. Lewis, Nathan L. Hendel, Cynthia M. Chio
Publikováno v:
Biology Open
Biology open, vol 7, iss 7
Biology Open, Vol 7, Iss 7 (2018)
Mavor, D; Barlow, KA; Asarnow, D; Birman, Y; Britain, D; Chen, W; et al.(2018). Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance. BIOLOGY OPEN, 7(7). doi: 10.1242/bio.036103. UCSF: Retrieved from: http://www.escholarship.org/uc/item/2hz894gr
Biology open, vol 7, iss 7
Biology Open, Vol 7, Iss 7 (2018)
Mavor, D; Barlow, KA; Asarnow, D; Birman, Y; Britain, D; Chen, W; et al.(2018). Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance. BIOLOGY OPEN, 7(7). doi: 10.1242/bio.036103. UCSF: Retrieved from: http://www.escholarship.org/uc/item/2hz894gr
Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it is highly tolerant to mutation during selection experiments performed in the laboratory. We have proposed that this discrepancy results from the di