Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Douglas Marvel"'
Autor:
Evgenii N. Tcyganov, Emilio Sanseviero, Douglas Marvel, Thomas Beer, Hsin-Yao Tang, Peter Hembach, David W. Speicher, Qianfei Zhang, Laxminarasimha R. Donthireddy, Ali Mostafa, Sabina Tsyganova, Vladimir Pisarev, Terri Laufer, Dmitriy Ignatov, Soldano Ferrone, Christiane Meyer, Hélène Maby-El Hajjami, Daniel E. Speiser, Sooner Altiok, Scott Antonia, Xiaowei Xu, Wei Xu, Cathy Zheng, Lynn M. Schuchter, Ravi K. Amaravadi, Tara C. Mitchell, Giorgos C. Karakousis, Zhe Yuan, Luis J. Montaner, Esteban Celis, Dmitry I. Gabrilovich
Publikováno v:
Cancer Cell
Cancer immunotherapy often depends on recognition of peptide epitopes by cytotoxic T lymphocytes (CTLs). The tumor microenvironment (TME) is enriched for peroxynitrite (PNT), a potent oxidant produced by infiltrating myeloid cells and some tumor cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76784efda1078b089d38e93bcaa2cedb
https://hdl.handle.net/21.11116/0000-000D-0838-C
https://hdl.handle.net/21.11116/0000-000D-0838-C
Publikováno v:
The Journal of Immunology. 190:3319-3327
Dendritic cells (DC) elicit immunity to pathogens and tumors while simultaneously preserving tolerance to self. Efficacious cancer vaccines have been a challenge because they are based on tumor Ags, some of which are self-Ags and thus subject to self
Autor:
Timothy Chao, Brian Nam, Lucia R. Languino, Prashanthi Vonteddu, Ellen Puré, David W. Speicher, Fred Denstman, Sergio Lavilla-Alonso, Shanti Shakamuri, Thomas Condamine, Linda A. Snyder, Douglas Marvel, Andrey Loboda, Manuel A. Sepulveda, Albert C. Lo, Marlee A. Goins, Dmitry I. Gabrilovich, Peter Ordentlich, Ayumi Hashimoto, Qin Liu, Robert H. Vonderheide, Ashani T. Weeraratna, Reeti Behera, Xiaowei Xu, Charles Mulligan, Laxminarasimha Donthireddy, Neil Hockstein, Vinit Kumar, Chunsheng Zhang, Fang Wang
Publikováno v:
Cancer Cell. 32:654-668.e5
Tumor-associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited anti-tumor effects. Here, we have identified the mechanism that limited th
Autor:
Olivera J. Finn, Douglas Marvel
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
Frontiers in Immunology
Frontiers in Immunology
DC in the spleen are highly activated following intravenous vaccination with a foreign antigen, promoting expansion of effector T cells, but remain phenotypically and functionally immature after vaccination with a self-antigen. Up-regulation or suppr
Autor:
Dmitry I. Gabrilovich, Douglas Marvel
Publikováno v:
Cancer Research. 75:4051-4051
The presence of peroxynitrite (PNT) in tumor tissue, as measured by its surrogate tissue marker, nitrotyrosine (NT), is correlated with poor clinical prognosis and poor response to immunotherapy. The production of PNT at the tissue can be attributed
Autor:
Douglas Marvel, Olivera Finn
Publikováno v:
The Journal of Immunology. 190:47.4-47.4
Mice transgenic for the human tumor antigen MUC1 (MUC1.Tg) are hyporesponsive to MUC1 peptide relative to WT mice. A recently identified biomarker of this hyporesponsiveness is suppression in splenic dendritic cells (DC) of a family of pancreatic enz
Autor:
Douglas Marvel, Olivera Finn
Publikováno v:
The Journal of Immunology. 188:46.7-46.7
Previous work by our lab and others has shown that human MUC1 transgenic mice (MUC1.tg) are hyporesponsive to vaccination with some forms of MUC1 and fail to mount a spontaneous immune response against MUC1 positive tumors. An interesting correlate o
Autor:
Douglas Marvel, Olivera Finn
Publikováno v:
The Journal of Immunology. 186:52.15-52.15
MUC1.Tg mice express the human tumor associated antigen MUC1 in a physiological pattern that is analogous to its expression on normal human epithelial cells and tumors. Vaccine-induced responses to MUC1 peptide in these animals are weak compared to W