Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Douglas M. Tollefsen"'
Autor:
Robin J Marjoram, Zhengzhi Li, Li He, Douglas M Tollefsen, Thomas J Kunicki, S Kent Dickeson, Samuel A Santoro, Mary M Zutter
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e114035 (2014)
Platelets express the α2β1 integrin and the glycoprotein VI (GPVI)/FcRγ complex, both collagen receptors. Understanding platelet-collagen receptor function has been enhanced through use of genetically modified mouse models. Previous studies of GPV
Externí odkaz:
https://doaj.org/article/a0186060a2c64848bb49810c27afac21
Autor:
Artur Schmidtchen, Douglas M. Tollefsen, Gopinath Kasetty, Martina Kalle, Praveen Papareddy, Matthias Mörgelin, Martin Malmsten
Publikováno v:
The Journal of Immunology. 190:6303-6310
The abundant serine proteinase inhibitor heparin cofactor II (HCII) has been proposed to inhibit extravascular thrombin. However, the exact physiological role of this plasma protein remains enigmatic. In this study, we demonstrate a previously unknow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c95b3caa7210df68183cfa56b1ed0e
https://doi.org/10.4049/jimmunol.1203030
https://doi.org/10.4049/jimmunol.1203030
Autor:
Rosalyn Sulyanto, Despina Sitara, Kelly Tsang, Li He, Kirsten Sigrist, Antonios O. Aliprantis, Douglas M. Tollefsen, Jing Wu, Nicholas J. Brady, Fabienne Coury, Daniel R. Storm, Julia F. Charles
Publikováno v:
Bone. 51:902-912
Osteoclasts are specialized secretory cells of the myeloid lineage important for normal skeletal homeostasis as well as pathologic conditions of bone including osteoporosis, inflammatory arthritis and cancer metastasis. Differentiation of these multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457d72a1fbb667d5ded0e2a852981e4d
https://doi.org/10.1016/j.bone.2012.08.113
https://doi.org/10.1016/j.bone.2012.08.113
Publikováno v:
Journal of Thrombosis and Haemostasis. 9:1292-1300
Summary. Background: As a regulator of the penultimate step in the coagulation cascade, thrombin represents a principal target of direct and specific anticoagulants. Objective: A potent thrombin inhibitor complexed with a colloidal nanoparticle was d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697e40d707d80f0424abc7d5d9476f46
https://doi.org/10.1111/j.1538-7836.2011.04339.x
https://doi.org/10.1111/j.1538-7836.2011.04339.x
Publikováno v:
Journal of Thrombosis and Haemostasis. 9:350-360
Summary. Background: We found a high incidence of thrombotic deaths in COX-1+/−COX-2−/− mice and sought to define the mechanism of these events. The cyclooxygenase products thromboxane A2 and prostacyclin are important in the regulation of coag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c85c098a41a2e81a1c2a1848fbc275
https://doi.org/10.1111/j.1538-7836.2010.04156.x
https://doi.org/10.1111/j.1538-7836.2010.04156.x
Autor:
Kevin K. Ohlemiller, Attila Kovacs, Li He, Douglas M. Tollefsen, Jason A. Metcalf, Axel Schambach, Xiucui Ma, Susan Wu, Bruce Linders, Katherine P. Ponder, Mark Bigg
Publikováno v:
Molecular Therapy. 18(2):334-342
Mucopolysaccharidosis I (MPS I) is a lysosomal storage disease due to deficiency in alpha-L-iduronidase (IDUA) that results in accumulation of glycosaminoglycans (GAGs) throughout the body, causing numerous clinical defects. Intravenous administratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ac421f9ac25c539b04f9ac7d30f166
Autor:
Vitor H. Pomin, Douglas M. Tollefsen, Mauro S. G. Pavão, Ana Paula Valente, Paulo A.S. Mourão, Mariana S. Pereira
Publikováno v:
Glycobiology. 15:369-381
A linear sulfated fucan with a regular repeating sequence of [3)-[alpha]-L-Fucp-(2SO₄)-(1[rightwards arrow]3)-[alpha]-L-Fucp-(4SO₄)-(1[rightwards arrow]3)-[alpha]-L-Fucp-(2,4SO₄)-(1[rightwards arrow]3)-[alpha]-L-Fucp-(2SO₄)-(1[rightwards arro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31049c0179ea6b51e44beb135157ac2
https://doi.org/10.1093/glycob/cwi021
https://doi.org/10.1093/glycob/cwi021
Publikováno v:
Thrombosis Research. 130:646-648
The thrombin mutant W215A/E217A (WE thrombin) has greatly reduced procoagulant activity, but it activates protein C in the presence of thrombomodulin and inhibits binding of platelet glycoprotein Ib to von Willebrand factor and collagen under flow co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5bac7d0d4ced5fa045978f79a0c0cf
https://doi.org/10.1016/j.thromres.2011.11.026
https://doi.org/10.1016/j.thromres.2011.11.026
Autor:
Douglas M. Tollefsen
Publikováno v:
Archives of Pathology & Laboratory Medicine. 126:1394-1400
Objectives.—To review of the state of the art relating to congenital heparin cofactor II deficiency as a potential risk factor for thrombosis, as reflected by the medical literature and the consensus opinion of recognized experts in the field, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f7d91a436b318088c50e6603f24f37
https://doi.org/10.5858/2002-126-1394-hcid
https://doi.org/10.5858/2002-126-1394-hcid
Publikováno v:
Journal of Biological Chemistry. 277:6788-6798
The substrate specificity of thrombin is regulated by binding of macromolecular substrates and effectors to exosites I and II. Exosites I and II have been reported to be extremely linked allosterically, such that binding of a ligand to one exosite re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0117f3a83ef6213ee3c43940ce5c0e0b
https://doi.org/10.1074/jbc.m110257200
https://doi.org/10.1074/jbc.m110257200