Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Douglas M. Jewett"'
Autor:
Mathew P. Leese, Yu Chi Shen, Daysha Ferrer-Torres, Kate F. Barald, Wolfgang Dohle, Ravi Upadhyayula, Tammy Hsia, Barry V. L. Potter, Stephanie Cevallos, Ryan J. Messick, Douglas M. Jewett, Therese M. Roth
Publikováno v:
British Journal of Cancer
Background: Both the number and size of tumours in NF1 patients increase in response to the rise in steroid hormones seen at puberty and during pregnancy. The size of tumours decreases after delivery, suggesting that hormone-targeting therapy might p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4288bf0d900ef0e86ae35fa044927f6
https://doi.org/10.1038/bjc.2015.345
https://doi.org/10.1038/bjc.2015.345
Autor:
Yolanda R. Smith, Charles R. Meyer, Yanjun Xu, Joshua A. Bueller, Douglas M. Jewett, Jon Kar Zubieta, Robert A. Koeppe, Christian S. Stohler, Michael R. Kilbourn
Publikováno v:
The Journal of Neuroscience. 22:5100-5107
Sex differences in the experience of clinical and experimental pain have been reported. However, the neurobiological sources underlying the variability in pain responses between sexes have not been adequately explored, especially in humans. The endog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6cc21cac3ae2698a709a309c44d59ca
https://doi.org/10.1523/jneurosci.22-12-05100.2002
https://doi.org/10.1523/jneurosci.22-12-05100.2002
Publikováno v:
Synapse. 45:31-37
We recently reported the synthesis and binding affinity of ligands for the muscarinic acetylcholine receptor (mAChR) based on both the pyrrolidyl and piperidyl benzilate scaffold. One of these, (R)-3-pyrrolidyl benzilate, was successfully radiolabele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a8aa8429c39c828379aa14f213c9b7
https://doi.org/10.1002/syn.10079
https://doi.org/10.1002/syn.10079
Autor:
Douglas M. Jewett, Michael R. Kilbourn
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 45:281-289
[11C]Paraquat was synthesized by the reaction of [11C]methyl triflate with the mono-triflate salt of 1-methyl-[4,4′]bipyridinyl. The product was selectively separated from the precursor by a microcolumn of Chelex 100 ion exchange resin. The method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af2655e2474b4257b4a9914ad2ca06b4
https://doi.org/10.1002/jlcr.564
https://doi.org/10.1002/jlcr.564
Autor:
Charles R. Meyer, Yanjun Xu, Michael R. Kilbourn, Christian S. Stohler, Joshua A. Bueller, Yolanda R. Smith, Douglas M. Jewett, Jon Kar Zubieta, Robert A. Koeppe
Publikováno v:
Science. 293:311-315
The endogenous opioid system is involved in stress responses, in the regulation of the experience of pain, and in the action of analgesic opiate drugs. We examined the function of the opioid system and μ-opioid receptors in the brains of healthy hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82208289d8f1e083114ecf5c498c9bdb
https://doi.org/10.1126/science.1060952
https://doi.org/10.1126/science.1060952
Autor:
Charles R. Schuster, James H. Woods, Jon Kar Zubieta, Chris Ellyn Johanson, Robert A. Koeppe, Michael R. Kilbourn, Umberto Lombardi, Mark K. Greenwald, Douglas M. Jewett
Publikováno v:
Neuropsychopharmacology. 23:326-334
A principle of opioid pharmacotherapy is that high medication doses should occupy fractionally more opioid receptors that mediate heroin effects. In this preliminary study we examined in vivo mu opioid receptor (muOR) binding in three healthy opioid-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98362a385671120eede43a4af03d67b
https://doi.org/10.1016/s0893-133x(00)00110-x
https://doi.org/10.1016/s0893-133x(00)00110-x
Autor:
Scott E. Snyder, David E. Kuhl, Michael R. Kilbourn, Douglas M. Jewett, Thinh B. Nguyen, Louis Tluczek
Publikováno v:
Nuclear Medicine and Biology. 25:751-754
Synthesis of 1-[ 11 C]methylpiperidin-4-yl propionate ([ 11 C]PMP), an in vivo substrate for acetylcholinesterase, is reported. An improved preparation of 4-piperidinyl propionate (PHP), the immediate precursor for radiolabeling, was accomplished in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054047564e8e94600fceb74fca91ffbb
https://doi.org/10.1016/s0969-8051(98)00045-6
https://doi.org/10.1016/s0969-8051(98)00045-6
Publikováno v:
Chirality. 9:59-62
Chiral column liquid chromatography and enantiospecific enzymatic hydrolysis were utilized to separate the enantiomers of alpha- and beta-dihydrotetrabenazine and alpha-9-O-desmethyldihydrotetrabenazine, three benzo[a]quinolizines derived from the am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::721c953c94fa3da4796cc0e121728f2b
https://doi.org/10.1002/(sici)1520-636x(1997)9:1<59::aid-chir11>3.0.co
https://doi.org/10.1002/(sici)1520-636x(1997)9:1<59::aid-chir11>3.0.co
Publikováno v:
European Journal of Pharmacology. 278:249-252
The two enantiomers of alpha-dihydrotetrabenazine were separated using chiral high performance liquid chromatography. The (+)-isomer showed high affinity in vitro (Ki = 0.97 +/- 0.48 nM) for the vesicular monoamine transporter (VMAT2) in rat brain st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32dd83e32f1bf64286b4c6b8346135e3
https://doi.org/10.1016/0014-2999(95)00162-e
https://doi.org/10.1016/0014-2999(95)00162-e
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 44:S330-S332
The hormone dependency of prostate cancer is well established and androgen receptor (AR) expression is frequently observed in primary prostate tumors and metastases (1). As a consequence, the development of radioligands that target the AR for prostat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::614e0a3c1401409ce0e48bc7f72df6fd
https://doi.org/10.1002/jlcr.25804401116
https://doi.org/10.1002/jlcr.25804401116