Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Douglas M. Gersten"'
Autor:
Daniel R. Vlock, William E. Brown, Douglas M. Gersten, Avishag Toporowicz, Vincent J. Hearing
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1182:51-56
We have previously reported the purification and partial characterization of a human melanoma-associated antigen (M-66) recognized by autologous antibody. This antigen was found to be an unusually acidic 66 kDa glycoprotein. In studies of murine mela
Autor:
Nicolas Kouttab, Abby Maizel, Douglas M. Gersten, David Shrayer, Vincent J. Hearing, Harold J. Wanebo
Publikováno v:
International Journal of Cancer. 53:696-702
The goal of our experiments was to determine the extent to which the humoral response to a melanoma vaccine elicits the production of cytotoxic antibodies in tumor-challenged mice. Mice were immunized with a vaccine produced from formalinized extrace
Autor:
Douglas M. Gersten, Harold J. Wanebo, David Shrayer, Vincent J. Hearing, James Koness, Abby Maizel
Publikováno v:
Pigment Cell Research. 5:107-112
Formalin fixation has enjoyed widespread use in the preparation of antibacterial and other vaccines, but rather less use in antitumor vaccines. Previous studies from our laboratories have demonstrated the efficacy of antimelanoma vaccines in mice, pr
Autor:
Douglas M. Gersten, Othmar Gabriel
Publikováno v:
Analytical Biochemistry. 203:181-186
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1138:109-114
Two unique murine melanoma antigens, termed B700 and B50, have been identified and isolated from several different murine melanoma cell lines. Both antigens can be detected on the cell surface, are actively shed in culture, and are often found in clo
Autor:
Karen E. Bijwaard, Douglas M. Gersten
Publikováno v:
Electrophoresis. 13:282-286
The presence of soluble dextrans, methylcellulose and polyethylene glycol polymers incorporated into vertical sodium dodecyl sulfate (SDS)-polyacrylamide slabs during electrophoresis can have a pronounced effect on protein separations. The effects of
Publikováno v:
European Journal of Cancer and Clinical Oncology. 27:1158-1162
B700, a murine melanoma-specific antigen, is a member of the serum albumin protein family. Other members include serum albumin and vitamin D binding protein. The primary structure and biochemical functions of B700, as well as its in vivo metabolic fa
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1096:20-25
B50 is a murine melanoma-associated antigen found in tight association with B700, a melanoma-specific antigen. B700-like molecules are produced by all melanomas tested to date, including those of murine, human, swine and hamster origin. We have used
Autor:
Wilfred D. Vieira, Richard D. Sontheimer, K Bijwaard, Douglas M. Gersten, Vincent J. Hearing, Tsu-San Lieu
Publikováno v:
Melanoma research. 5(5)
B50 is a 50 kDa protein antigen originally identified and isolated from cultured B16 murine melanoma cells; it is found in close association with a melanoma-specific antigen termed B700. Using a specific rabbit antiserum, B50 (or B50 cross-reactive m
Publikováno v:
The Journal of dermatology. 21(11)
We have investigated the potential use of immune therapies on the growth of melanoma metastases in a new animal model that more closely approximates the clinical situation. We have found that significant benefits towards decreased metastatic growth a