Denervation causes fiber atrophy and myosin heavy chain co-expression in senescent skeletal muscle.

Autor: Sharon L Rowan, Karolina Rygiel, Fennigje M Purves-Smith, Nathan M Solbak, Douglas M Turnbull, Russell T Hepple

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e29082 (2012)

Although denervation has long been implicated in aging muscle, the degree to which it is causes the fiber atrophy seen in aging muscle is unknown. To address this question, we quantified motoneuron soma counts in the lumbar spinal cord using choline

Externí odkaz: https://doaj.org/article/8822946490c44532ad6ad11b8f0cc621

A Methodological Approach to Tracing Cell Lineage in Human Epithelial Tissues

Autor: Lydia Gutierrez-Gonzalez, Patrick F. Chinnery, Paul J. Tadrous, Tariq G. Fellous, Mona El-Bahrawy, Stuart McDonald, Satyajit Bhattacharya, Robert W. Taylor, Julia Burkert, Lisa Mears, Laura C. Greaves, George Elia, Christopher P. Day, Malcolm R. Alison, Adam Humphries, Hemant M. Kocher, Nemantha M.W. De‐Alwis, Douglas M. Turnbull, Nicholas A. Wright, Shahriar Islam

Publikováno v: Stem Cells. 27:1410-1420

Methods for lineage tracing of stem cell progeny in human tissues are currently not available. We describe a technique for detecting the expansion of a single cell's progeny that contain clonal mitochondrial DNA (mtDNA) mutations affecting the expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9098325d64a221c6d52bce1bed50dc66
https://doi.org/10.1002/stem.67

Mitochondrial defects in acute multiple sclerosis lesions

Autor: Don J. Mahad, Douglas M. Turnbull, Iryna Ziabreva, Hans Lassmann

Publikováno v: Brain
Mahad, D, Ziabreva, I, Lassmann, H & Turnbull, D 2008, ' Mitochondrial defects in acute multiple sclerosis lesions ', Brain, vol. 131, no. 7, pp. 1722-1735 . https://doi.org/10.1093/brain/awn105

Multiple sclerosis is a chronic inflammatory disease, which leads to focal plaques of demyelination and tissue injury in the CNS. The structural and immunopathological patterns of demyelination suggest that different immune mechanisms may be involved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afc31ec1a7fa617240c152acb7bcea0
http://europepmc.org/articles/PMC2442422

New treatments for mitochondrial disease-no time to drop our standards

Autor: Anu Suomalainen, Kari Majamaa, Patrick F. Chinnery, Michael G. Hanna, Douglas M. Turnbull, Valerio Carelli, Saskia Koene, Laurence A. Bindoff, Patrick Yu-Wai-Man, Robert McFarland, Rita Horvath, Michio Hirano, Jan A.M. Smeitink, Massimo Zeviani, Vamsi K. Mootha, Thomas Klopstock, Gerald Pfeffer

Publikováno v: Nature Reviews. Neurology, 9, 474-81
Nature Reviews Neurology; Vol 9
Nature Reviews. Neurology, 9, 8, pp. 474-81

Item does not contain fulltext Mitochondrial dysfunction is a common cause of inherited multisystem disease that often involves the nervous system. Despite major advances in our understanding of the pathophysiology of mitochondrial diseases, clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134876d5b52d9826a8aa956e00c9a4e6
http://hdl.handle.net/2066/128647

Repeats, longevity and the sources of mtDNA deletions: evidence from 'deletional spectra'

Autor: Kim J. Krishnan, Yevgenya Kraytsberg, Douglas M. Turnbull, Yuriy L. Orlov, Konstantin Popadin, Konstantin Khrapko, Gábor Zsurka, Wolfram S. Kunz, Natalya Markuzon, Xinhong Guo

Publikováno v: Trends in genetics : TIG. 26(8)

Perfect direct repeats and, in particular, the prominent 13 bp repeat, are thought to cause mitochondrial DNA (mtDNA) deletions, which have been associated with the aging process. Accordingly, individuals lacking the 13 bp repeat are highly prevalent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48f3ccbfa04cf82183227e71016f228
https://pubmed.ncbi.nlm.nih.gov/20591530